Ophthalmic Drug Delivery: Advancement, Industrialization Prospect and Applications delves into the complexities and potential of scaling up and commercializing pharmaceutical innovations within ophthalmology. This book serves as a complete guide through research findings, industry insights, and regulatory guidelines, offering a thorough roadmap for the future of drug delivery systems targeting the eye. The importance of understanding the eye's physiology and anatomy is emphasized, laying the foundational knowledge necessary for developing effective treatments. The book continues by exploring various aspects such as novel formulations, fixed-dose combinations, and microbiological considerations.
It also discusses cutting-edge research in reverse engineering approaches, the significance of Quality by Design (QbD), and the treatment of eye-related diseases like glaucoma, age-related macular degeneration, uveal melanoma, cataracts, and fungal keratitis. Corporate researchers will find the manufacturing insights particularly beneficial, making this an essential resource for professionals in the field of ophthalmic drug delivery.
1. Cover image - p. c 2. Title page - p. i 3. Copyright - p. iv 4. Dedication - p. v 5. Table of Contents - p. vii 6. Contributors - p. xix 7. About the Editor - p. xxv 8. Foreword - p. xxvii 9. Preface - p. xxix 10. Acknowledgments - p. xxxi 11. Chapter 1 Ocular drug delivery: Core principles and fundamental concepts - p. 1 12. Chapter 2 Complex ophthalmic drug delivery approaches - p. 25 13. Chapter 3 Excipients and polymers in complex ophthalmic products: Formulation science and engineering perspectives - p. 51 14. Chapter 4 Fixed-dose combination techniques in ophthalmic products - p. 83 15. Chapter 5 Emerging trends in ophthalmic products: Microneedles, hydrogels, and ocular inserts - p. 111 16. Chapter 6 Reverse engineering strategy in complex ophthalmic product - p. 171 17. Chapter 7 Quality by design in ophthalmic product development - p. 193 18. Chapter 8 Translational roadmap for complex ophthalmic products - p. 219 19. Chapter 9 Manufacturing consideration, scale-up, and validation in sterile ophthalmic formulation - p. 255 20. Chapter 10 Safety assessment and toxicological considerations of nanocarriers in ophthalmic drug delivery - p. 293 21. Chapter 11 Advanced packaging, containers, and closure systems for complex ophthalmic products - p. 361 22. Chapter 12 Role of 3D printing in ophthalmic products - p. 391 23. Chapter 13 Stability studies of ophthalmic products - p. 419 24. Chapter 14 Regulatory landscape of ophthalmic products - p. 445 25. Index - p. 469
Ophthalmic Drug Delivery: Advancement, Industrialization Prospect and Applications delves into the complexities and potential of scaling up and commercializing pharmaceutical innovations within ophthalmology. This book serves as a complete guide through research findings, industry insights, and regulatory guidelines, offering a thorough roadmap for the future of drug delivery systems targeting the eye. The importance of understanding the eye's physiology and anatomy is emphasized, laying the foundational knowledge necessary for developing effective treatments. The book continues by exploring various aspects such as novel formulations, fixed-dose combinations, and microbiological considerations.
It also discusses cutting-edge research in reverse engineering approaches, the significance of Quality by Design (QbD), and the treatment of eye-related diseases like glaucoma, age-related macular degeneration, uveal melanoma, cataracts, and fungal keratitis. Corporate researchers will find the manufacturing insights particularly beneficial, making this an essential resource for professionals in the field of ophthalmic drug delivery.
1. Cover image - p. c 2. Title page - p. i 3. Copyright - p. iv 4. Dedication - p. v 5. Table of Contents - p. vii 6. Contributors - p. xix 7. About the Editor - p. xxv 8. Foreword - p. xxvii 9. Preface - p. xxix 10. Acknowledgments - p. xxxi 11. Chapter 1 Ocular drug delivery: Core principles and fundamental concepts - p. 1 12. Chapter 2 Complex ophthalmic drug delivery approaches - p. 25 13. Chapter 3 Excipients and polymers in complex ophthalmic products: Formulation science and engineering perspectives - p. 51 14. Chapter 4 Fixed-dose combination techniques in ophthalmic products - p. 83 15. Chapter 5 Emerging trends in ophthalmic products: Microneedles, hydrogels, and ocular inserts - p. 111 16. Chapter 6 Reverse engineering strategy in complex ophthalmic product - p. 171 17. Chapter 7 Quality by design in ophthalmic product development - p. 193 18. Chapter 8 Translational roadmap for complex ophthalmic products - p. 219 19. Chapter 9 Manufacturing consideration, scale-up, and validation in sterile ophthalmic formulation - p. 255 20. Chapter 10 Safety assessment and toxicological considerations of nanocarriers in ophthalmic drug delivery - p. 293 21. Chapter 11 Advanced packaging, containers, and closure systems for complex ophthalmic products - p. 361 22. Chapter 12 Role of 3D printing in ophthalmic products - p. 391 23. Chapter 13 Stability studies of ophthalmic products - p. 419 24. Chapter 14 Regulatory landscape of ophthalmic products - p. 445 25. Index - p. 469
