Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described.
Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models.
1. Introduction - p. 47 2. Microengineering - p. 50 3. Engineering fluid control for organ-on-chips - p. 68 4. Stimulation and sensing - p. 89 5. References - p. 111 6. Part I: Organ-on-a-chip platforms to model disease pathogenesis - p. 111 7. Chapter 4. Lung-on-a-chip platforms for modeling disease pathogenesis - p. 133 8. Chapter 5. Requirements for designing organ-on-a-chip platforms to model the pathogenesis of liver disease - p. 181 9. Chapter 6. Brain-on-a-chip systems for modeling disease pathogenesis - p. 215 10. Chapter 7. Kidney-on-a-chip - p. 233 11. Chapter 8. Heart-on-a-chip - p. 255 12. Chapter 9. Gut-on-a-chip microphysiological systems for the recapitulation of the gut microenvironment - p. 295 13. Chapter 10. Computational pharmacokinetic modeling of organ-on-chip devices and microphysiological systems - p. 311 14. Chapter 11. Caenorhabditis elegans-on-a-chip: microfluidic platforms for high-resolution imaging and phenotyping - p. 363 15. Part II: Multi-organs-on-a-chip platforms to mimic humans physiology - p. 382 16. Chapter 12. Design and engineering of multiorgan systems - p. 393 17. Chapter 13. Human body-on-a-chip systems - p. 429 18. Chapter 14. Automation and opportunities for industry scale-up of microphysiological systems - p. 441 19. Chapter 15. How to build your multiorgan-on-a-chip system: a case study - p. 463 20. Index - p. 507
Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described.
Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models.
1. Introduction - p. 47 2. Microengineering - p. 50 3. Engineering fluid control for organ-on-chips - p. 68 4. Stimulation and sensing - p. 89 5. References - p. 111 6. Part I: Organ-on-a-chip platforms to model disease pathogenesis - p. 111 7. Chapter 4. Lung-on-a-chip platforms for modeling disease pathogenesis - p. 133 8. Chapter 5. Requirements for designing organ-on-a-chip platforms to model the pathogenesis of liver disease - p. 181 9. Chapter 6. Brain-on-a-chip systems for modeling disease pathogenesis - p. 215 10. Chapter 7. Kidney-on-a-chip - p. 233 11. Chapter 8. Heart-on-a-chip - p. 255 12. Chapter 9. Gut-on-a-chip microphysiological systems for the recapitulation of the gut microenvironment - p. 295 13. Chapter 10. Computational pharmacokinetic modeling of organ-on-chip devices and microphysiological systems - p. 311 14. Chapter 11. Caenorhabditis elegans-on-a-chip: microfluidic platforms for high-resolution imaging and phenotyping - p. 363 15. Part II: Multi-organs-on-a-chip platforms to mimic humans physiology - p. 382 16. Chapter 12. Design and engineering of multiorgan systems - p. 393 17. Chapter 13. Human body-on-a-chip systems - p. 429 18. Chapter 14. Automation and opportunities for industry scale-up of microphysiological systems - p. 441 19. Chapter 15. How to build your multiorgan-on-a-chip system: a case study - p. 463 20. Index - p. 507
