Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by internationally renowned experts Drs. Scott P. Bruder and Roy K. Aaron, Orthobiologics: Scientific and Clinical Solutions for Orthopaedic Surgeons provides authoritative, comprehensive coverage of this fast-growing field. This one-stop reference is an ideal resource, covering technology and basic science through specific clinical applications.
1. Introduction - p. xvii 2. Contents - p. xix 3. PART 1: Foundational Principles - p. 1 4. Section 1: Biologic Options for Tissue Repair and Regeneration - p. 3 5. 1 Cell Biology and Cell Sources - p. 5 6. 2 Materials Science and Biodegradable Scaffolds - p. 17 7. 3 Bioactive Factors and Designer Molecules - p. 33 8. 4 Gene Therapy - p. 43 9. 5 Clinically Applicable and Translatable Animal Models in Orthobiologic Research for Cartilage Repair and Osteoarthritis in Humans - p. 61 10. 6 Overview of Orthobiologics for Articular Cartilage Repair - p. 85 11. 7 Overview of Orthobiologics for Bone Repair - p. 103 12. 8 Orthobiologics for Tendon and Ligament Repair - p. 119 13. 9 Summary and Perspectives - p. 141 14. Section 2 Technology Development, Regulation, and the Commercialization Pathway - p. 145 15. 10 Pitfalls in the Assessment of Outcomes in Randomized Clinical Trials - p. 147 16. 11 Measuring and Reporting Outcomes - p. 155 17. 12 The US FDA Regulatory Landscape and Compliance - p. 169 18. 13 Product Development - p. 185 19. 14 Allograft and Xenograft Tissue Technology - p. 195 20. 15 Product and Provider Reimbursement in the Field of Orthobiologics - p. 205 21. 16 Summary and Perspectives - p. 215 22. PART 2: Clinical Applications - p. 219 23. Section 3: Solutions for Upper Extremity Pathology - p. 221 24. 17 Rotator Cuff Repair - p. 223 25. 18 Tendon Management, Protection, and Repair - p. 233 26. 19 Fresh Fracture, Challenging Bone Repair, and Nonunions - p. 245 27. 20 Peripheral Nerve Regeneration in the Hand - p. 265 28. 21 Skeletal Muscle Regeneration - p. 277 29. 22 Measurement of Clinical Outcomes in the Upper Extremity - p. 293 30. 23 Summary and Perspectives - p. 305 31. Section 4: Solutions for Lower Extremity Pathology - p. 309 32. 24 Segmental Defect Repair and Nonunion - p. 311 33. 25 Meniscal Repair and Replacement - p. 327 34. 26 Articular Cartilage Repair—Cells and Biomaterials - p. 345 35. 27 Knee and Ankle Osteoarthritis—Injectables - p. 359 36. 28 Ligament Repair and Regeneration - p. 369 37. 29 Clinical Outcomes in the Hip and Knee Following Arthroplasty - p. 381 38. 30 Biologic Considerations for Clinical Study Design: Cartilage Repair - p. 391 39. 31 Summary and Perspectives - p. 401 40. Section 5: Solutions for Spinal Pathology - p. 405 41. 32 Intervertebral Disk Repair and Regeneration—Bioactive Factors and Cell-Based Therapy - p. 407 42. 33 Spine Fusion—Bioactive Factor Based - p. 435 43. 34 Measurement of Clinical Outcomes in Spine - p. 469 44. 35 Biologic Considerations for Clinical Study Design: Fusion - p. 479 45. 36 Summary and Perspectives - p. 487 46. Index - p. 489
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Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by internationally renowned experts Drs. Scott P. Bruder and Roy K. Aaron, Orthobiologics: Scientific and Clinical Solutions for Orthopaedic Surgeons provides authoritative, comprehensive coverage of this fast-growing field. This one-stop reference is an ideal resource, covering technology and basic science through specific clinical applications.
1. Introduction - p. xvii 2. Contents - p. xix 3. PART 1: Foundational Principles - p. 1 4. Section 1: Biologic Options for Tissue Repair and Regeneration - p. 3 5. 1 Cell Biology and Cell Sources - p. 5 6. 2 Materials Science and Biodegradable Scaffolds - p. 17 7. 3 Bioactive Factors and Designer Molecules - p. 33 8. 4 Gene Therapy - p. 43 9. 5 Clinically Applicable and Translatable Animal Models in Orthobiologic Research for Cartilage Repair and Osteoarthritis in Humans - p. 61 10. 6 Overview of Orthobiologics for Articular Cartilage Repair - p. 85 11. 7 Overview of Orthobiologics for Bone Repair - p. 103 12. 8 Orthobiologics for Tendon and Ligament Repair - p. 119 13. 9 Summary and Perspectives - p. 141 14. Section 2 Technology Development, Regulation, and the Commercialization Pathway - p. 145 15. 10 Pitfalls in the Assessment of Outcomes in Randomized Clinical Trials - p. 147 16. 11 Measuring and Reporting Outcomes - p. 155 17. 12 The US FDA Regulatory Landscape and Compliance - p. 169 18. 13 Product Development - p. 185 19. 14 Allograft and Xenograft Tissue Technology - p. 195 20. 15 Product and Provider Reimbursement in the Field of Orthobiologics - p. 205 21. 16 Summary and Perspectives - p. 215 22. PART 2: Clinical Applications - p. 219 23. Section 3: Solutions for Upper Extremity Pathology - p. 221 24. 17 Rotator Cuff Repair - p. 223 25. 18 Tendon Management, Protection, and Repair - p. 233 26. 19 Fresh Fracture, Challenging Bone Repair, and Nonunions - p. 245 27. 20 Peripheral Nerve Regeneration in the Hand - p. 265 28. 21 Skeletal Muscle Regeneration - p. 277 29. 22 Measurement of Clinical Outcomes in the Upper Extremity - p. 293 30. 23 Summary and Perspectives - p. 305 31. Section 4: Solutions for Lower Extremity Pathology - p. 309 32. 24 Segmental Defect Repair and Nonunion - p. 311 33. 25 Meniscal Repair and Replacement - p. 327 34. 26 Articular Cartilage Repair—Cells and Biomaterials - p. 345 35. 27 Knee and Ankle Osteoarthritis—Injectables - p. 359 36. 28 Ligament Repair and Regeneration - p. 369 37. 29 Clinical Outcomes in the Hip and Knee Following Arthroplasty - p. 381 38. 30 Biologic Considerations for Clinical Study Design: Cartilage Repair - p. 391 39. 31 Summary and Perspectives - p. 401 40. Section 5: Solutions for Spinal Pathology - p. 405 41. 32 Intervertebral Disk Repair and Regeneration—Bioactive Factors and Cell-Based Therapy - p. 407 42. 33 Spine Fusion—Bioactive Factor Based - p. 435 43. 34 Measurement of Clinical Outcomes in Spine - p. 469 44. 35 Biologic Considerations for Clinical Study Design: Fusion - p. 479 45. 36 Summary and Perspectives - p. 487 46. Index - p. 489
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