Oxidative Stress: Eustress and Distress presents current knowledge on oxidative stress within the framework of redox biology and translational medicine. It describes eustress and distress in molecular terms and with novel imaging and chemogenetic approaches in four sections:
Oxidative Stress: Eustress and Distress is an informative resource useful for active researchers and students in biochemistry, molecular biology, medicinal chemistry, pharmaceutical science, nutrition, exercise physiology, analytical chemistry, cell biology, pharmacology, clinical medicine, and environmental science.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xxiii 6. Preface - p. xxxi 7. Part 1: Conceptual - p. xxxi 8. Chapter 1: Oxidative eustress and oxidative distress: Introductory remarks - p. xxxi 9. Chapter 2: Epistemological challenges of the oxidative stress theory of disease and the problem of biomarkers - p. 12 10. Chapter 3: Systems biology and network medicine: An integrated approach to redox biology and pathobiology - p. 27 11. Chapter 4: The reactive species interactome - p. 49 12. Part 2: Oxidative eustress and distress: Processes and responses - p. 64 13. Chapter 5: Oxidative stress and the early coevolution of life and biospheric oxygen - p. 64 14. Chapter 6: How imaging transforms our understanding of oxidative stress - p. 85 15. Chapter 7: In vivo applications of chemogenetics in redox (patho)biology - p. 96 16. Chapter 8: Quantification of intracellular H2O2: Methods and significance - p. 112 17. Chapter 9: The Keap1-Nrf2 pathway: From mechanism to medical applications - p. 124 18. Chapter 10: Ferroptosis: Physiological and pathophysiological aspects - p. 147 19. Chapter 11: Aquaporins: Gatekeepers in the borders of oxidative stress and redox signaling - p. 166 20. Chapter 12: Extracellular superoxide dismutase (SOD3): An antioxidant or prooxidant in the extracellular space? - p. 181 21. Chapter 13: Protein S-glutathionylation and the regulation of cellular functions - p. 215 22. Chapter 14: Dual stressor effects of lipid oxidation and antioxidants - p. 247 23. Chapter 15: Oxidized phospholipid signaling: Distress to eustress - p. 262 24. Chapter 16: Redox regulation of protein kinase signaling - p. 285 25. Chapter 17: FoxO transcription factors in the control of redox homeostasis and fuel metabolism - p. 313 26. Chapter 18: Oxidatively generated DNA base modifications: Relation to eustress and distress - p. 330 27. Chapter 19: Light-initiated oxidative stress - p. 361 28. Chapter 20: Nutritional protection against photooxidative stress in human skin and eye - p. 388 29. Part 3: Exposome - p. 402 30. Chapter 21: Mechanisms integrating lifelong exposure and health - p. 402 31. Chapter 22: Nutrient sensing, the oxidative stress response, and stem cell aging - p. 426 32. Chapter 23: How exercise induces oxidative eustress - p. 446 33. Chapter 24: Metabolomics as a tool to unravel the oxidative stress-induced toxicity of ambient air pollutants - p. 462 34. Chapter 25: Traffic-related environmental risk factors and their impact on oxidative stress and cardiovascular health - p. 488 35. Part 4: Oxidative stress in health and disease processes - p. 510 36. Chapter 26: Mitochondrial ROS production during ischemia-reperfusion injury - p. 510 37. Chapter 27: Redox signaling in cellular differentiation - p. 538 38. Chapter 28: Redox-regulated brain development - p. 563 39. Chapter 29: Eustress, distress, and oxidative stress: Promising pathways for mind-body medicine - p. 582 40. Chapter 30: Reactive oxygen species and cancer - p. 617 41. Chapter 31: Perspectives of TrxR1-based cancer therapies - p. 637 42. Chapter 32: Oxidative/nitrosative stress and hepatic encephalopathy - p. 667 43. Chapter 33: ROS signaling in complex systems: The gut - p. 693 44. Chapter 34: Oxidative stress in skeletal muscle: Unraveling the potential beneficial and deleterious roles of reactive oxygen species - p. 712 45. Chapter 35: Redox mechanisms in pulmonary disease: Emphasis on pulmonary fibrosis - p. 733 46. Chapter 36: Dicarbonyl stress and the glyoxalase system - p. 758 47. Chapter 37: Redox distress in organ fibrosis: The role of noncoding RNAs - p. 777 48. Index - p. 821
Oxidative Stress: Eustress and Distress presents current knowledge on oxidative stress within the framework of redox biology and translational medicine. It describes eustress and distress in molecular terms and with novel imaging and chemogenetic approaches in four sections:
Oxidative Stress: Eustress and Distress is an informative resource useful for active researchers and students in biochemistry, molecular biology, medicinal chemistry, pharmaceutical science, nutrition, exercise physiology, analytical chemistry, cell biology, pharmacology, clinical medicine, and environmental science.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xxiii 6. Preface - p. xxxi 7. Part 1: Conceptual - p. xxxi 8. Chapter 1: Oxidative eustress and oxidative distress: Introductory remarks - p. xxxi 9. Chapter 2: Epistemological challenges of the oxidative stress theory of disease and the problem of biomarkers - p. 12 10. Chapter 3: Systems biology and network medicine: An integrated approach to redox biology and pathobiology - p. 27 11. Chapter 4: The reactive species interactome - p. 49 12. Part 2: Oxidative eustress and distress: Processes and responses - p. 64 13. Chapter 5: Oxidative stress and the early coevolution of life and biospheric oxygen - p. 64 14. Chapter 6: How imaging transforms our understanding of oxidative stress - p. 85 15. Chapter 7: In vivo applications of chemogenetics in redox (patho)biology - p. 96 16. Chapter 8: Quantification of intracellular H2O2: Methods and significance - p. 112 17. Chapter 9: The Keap1-Nrf2 pathway: From mechanism to medical applications - p. 124 18. Chapter 10: Ferroptosis: Physiological and pathophysiological aspects - p. 147 19. Chapter 11: Aquaporins: Gatekeepers in the borders of oxidative stress and redox signaling - p. 166 20. Chapter 12: Extracellular superoxide dismutase (SOD3): An antioxidant or prooxidant in the extracellular space? - p. 181 21. Chapter 13: Protein S-glutathionylation and the regulation of cellular functions - p. 215 22. Chapter 14: Dual stressor effects of lipid oxidation and antioxidants - p. 247 23. Chapter 15: Oxidized phospholipid signaling: Distress to eustress - p. 262 24. Chapter 16: Redox regulation of protein kinase signaling - p. 285 25. Chapter 17: FoxO transcription factors in the control of redox homeostasis and fuel metabolism - p. 313 26. Chapter 18: Oxidatively generated DNA base modifications: Relation to eustress and distress - p. 330 27. Chapter 19: Light-initiated oxidative stress - p. 361 28. Chapter 20: Nutritional protection against photooxidative stress in human skin and eye - p. 388 29. Part 3: Exposome - p. 402 30. Chapter 21: Mechanisms integrating lifelong exposure and health - p. 402 31. Chapter 22: Nutrient sensing, the oxidative stress response, and stem cell aging - p. 426 32. Chapter 23: How exercise induces oxidative eustress - p. 446 33. Chapter 24: Metabolomics as a tool to unravel the oxidative stress-induced toxicity of ambient air pollutants - p. 462 34. Chapter 25: Traffic-related environmental risk factors and their impact on oxidative stress and cardiovascular health - p. 488 35. Part 4: Oxidative stress in health and disease processes - p. 510 36. Chapter 26: Mitochondrial ROS production during ischemia-reperfusion injury - p. 510 37. Chapter 27: Redox signaling in cellular differentiation - p. 538 38. Chapter 28: Redox-regulated brain development - p. 563 39. Chapter 29: Eustress, distress, and oxidative stress: Promising pathways for mind-body medicine - p. 582 40. Chapter 30: Reactive oxygen species and cancer - p. 617 41. Chapter 31: Perspectives of TrxR1-based cancer therapies - p. 637 42. Chapter 32: Oxidative/nitrosative stress and hepatic encephalopathy - p. 667 43. Chapter 33: ROS signaling in complex systems: The gut - p. 693 44. Chapter 34: Oxidative stress in skeletal muscle: Unraveling the potential beneficial and deleterious roles of reactive oxygen species - p. 712 45. Chapter 35: Redox mechanisms in pulmonary disease: Emphasis on pulmonary fibrosis - p. 733 46. Chapter 36: Dicarbonyl stress and the glyoxalase system - p. 758 47. Chapter 37: Redox distress in organ fibrosis: The role of noncoding RNAs - p. 777 48. Index - p. 821
