Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology.
This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms.
Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s.
1. Cover - p. i 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. ii 5. List of Contributors - p. iv 6. Preface - p. x 7. Chapter 1: The Neurogenetics of Parkinson’s Disease and Putative Links to Other Neurodegenerative Disorders - p. xii 8. Chapter 2: Electron Transport Chain - p. 40 9. Chapter 3: Mitochondrial Fission and Fusion - p. 75 10. Chapter 4: Axonal Mitochondrial Transport - p. 111 11. Chapter 5: Mitophagy - p. 137 12. Chapter 6: Autophagy - p. 177 13. Chapter 7: Endocytosis and Synaptic Function - p. 206 14. Chapter 8: Neuroinflammation as a Potential Mechanism Underlying Parkinsons Disease - p. 243 15. Chapter 9: Protein Translation in Parkinson’s Disease - p. 279 16. Index - p. 309
Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology.
This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms.
Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s.
1. Cover - p. i 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. ii 5. List of Contributors - p. iv 6. Preface - p. x 7. Chapter 1: The Neurogenetics of Parkinson’s Disease and Putative Links to Other Neurodegenerative Disorders - p. xii 8. Chapter 2: Electron Transport Chain - p. 40 9. Chapter 3: Mitochondrial Fission and Fusion - p. 75 10. Chapter 4: Axonal Mitochondrial Transport - p. 111 11. Chapter 5: Mitophagy - p. 137 12. Chapter 6: Autophagy - p. 177 13. Chapter 7: Endocytosis and Synaptic Function - p. 206 14. Chapter 8: Neuroinflammation as a Potential Mechanism Underlying Parkinsons Disease - p. 243 15. Chapter 9: Protein Translation in Parkinson’s Disease - p. 279 16. Index - p. 309
