Leishmaniasis is a neglected tropical disease that is known to be transmitted by 90 different species of sandflies which carry 20 Leishmania species that cause human infection particularly in endemic countries. Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to provide information on this vector-borne disease and explore strategies for diagnosis and treatment. The book begins with an overview of leishmaniasis which includes historical and future perspectives of the disease. It also discusses the clinical manifestation of the disease, mechanisms of infection, therapeutic strategies, diagnostics, prevention, and cure of Leishmania parasite. The book goes on to explain new insights and challenges in the development of promising drug targets, biomarkers identification and advance vaccination strategies against leishmaniasis. Chapter contributions brings together diverse areas of expertise making Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to bring together elements of leishmaniasis into one place and be a valuable resource for researchers, health care professionals, and graduate students, working in the field of leishmaniasis.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xiii 7. Preface - p. xv 8. Chapter 1. Leishmaniasis: an overview of evolution, classification, distribution, and historical aspects of parasite and its vector - p. 1 9. Chapter 2. Neoteric strategies for vector control and identification of zoonotic reservoirs - p. 27 10. Chapter 3. Recent advances in the diagnostic methods of Leishmaniasis - p. 45 11. Chapter 4. Recent advances on computational approach towards potential drug discovery against leishmaniasis - p. 63 12. DNA microarray analysis of Leishmania parasite: strengths and limitations - p. 85 13. Chapter 6. Drug resistance and repurposing of existing drugs in Leishmaniasis - p. 103 14. Chapter 7. Novel nanotechnology-based approaches in the treatment of leishmaniasis - p. 125 15. Chapter 8. Natural products as a novel source for antileishmanial drug development - p. 141 16. Chapter 9. Evaluation of biomarkers to monitor therapeutic intervention against visceral leishmaniasis - p. 161 17. Chapter 10. Development of a successful vaccine for leishmaniasis: possibilities and challenges - p. 183 18. Chapter 11. Interferon-γ: a key cytokine in leishmaniasis - p. 197 19. Apoptosis in Leishmania: biochemical footprint and its relevance to surmount leishmaniasis - p. 209 20. Chapter 13. Immunological determinants, host immune responses, and animal models of visceral leishmaniasis - p. 231 21. Index - p. 251
Leishmaniasis is a neglected tropical disease that is known to be transmitted by 90 different species of sandflies which carry 20 Leishmania species that cause human infection particularly in endemic countries. Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to provide information on this vector-borne disease and explore strategies for diagnosis and treatment. The book begins with an overview of leishmaniasis which includes historical and future perspectives of the disease. It also discusses the clinical manifestation of the disease, mechanisms of infection, therapeutic strategies, diagnostics, prevention, and cure of Leishmania parasite. The book goes on to explain new insights and challenges in the development of promising drug targets, biomarkers identification and advance vaccination strategies against leishmaniasis. Chapter contributions brings together diverse areas of expertise making Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to bring together elements of leishmaniasis into one place and be a valuable resource for researchers, health care professionals, and graduate students, working in the field of leishmaniasis.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xiii 7. Preface - p. xv 8. Chapter 1. Leishmaniasis: an overview of evolution, classification, distribution, and historical aspects of parasite and its vector - p. 1 9. Chapter 2. Neoteric strategies for vector control and identification of zoonotic reservoirs - p. 27 10. Chapter 3. Recent advances in the diagnostic methods of Leishmaniasis - p. 45 11. Chapter 4. Recent advances on computational approach towards potential drug discovery against leishmaniasis - p. 63 12. DNA microarray analysis of Leishmania parasite: strengths and limitations - p. 85 13. Chapter 6. Drug resistance and repurposing of existing drugs in Leishmaniasis - p. 103 14. Chapter 7. Novel nanotechnology-based approaches in the treatment of leishmaniasis - p. 125 15. Chapter 8. Natural products as a novel source for antileishmanial drug development - p. 141 16. Chapter 9. Evaluation of biomarkers to monitor therapeutic intervention against visceral leishmaniasis - p. 161 17. Chapter 10. Development of a successful vaccine for leishmaniasis: possibilities and challenges - p. 183 18. Chapter 11. Interferon-γ: a key cytokine in leishmaniasis - p. 197 19. Apoptosis in Leishmania: biochemical footprint and its relevance to surmount leishmaniasis - p. 209 20. Chapter 13. Immunological determinants, host immune responses, and animal models of visceral leishmaniasis - p. 231 21. Index - p. 251
