Pathologic Basis of Veterinary Disease

1. Introduction. Fundamentals for Understanding Veterinary Pathology - p. 1 2. Section I. Cellular and Molecular Mechanisms of Disease (General Pathology) - p. 13 3. Introduction - p. 15 4. Chapter 1. Mechanisms and Morphology of Cellular Injury, Adaptation, and Death - p. 16 5. Introduction - p. 16 6. Normal Cell - p. 16 7. Causes of Cell Injury - p. 22 8. Irreversible Cell Injury and Cell Death - p. 26 9. Chronic Cell Injury and Cell Adaptations - p. 36 10. Cell Cycle - p. 56 11. Cellular Aging - p. 57 12. Genetic Basis of Disease - p. 59 13. Chapter 2. Vascular Disorders and Thrombosis - p. 74 14. Chapter 3. Inflammation and Healing - p. 104 15. Introduction - p. 104 16. Evolution of the Current Understanding of Inflammation - p. 104 17. Beneficial and Harmful Aspects of Inflammation - p. 106 18. Acute Inflammation - p. 106 19. Substances Inducing the Acute Inflammatory Response - p. 109 20. Fluidic (Exudative) Phase of the Acute Inflammatory Response - p. 110 21. Cellular Phase of the Acute Inflammatory Response - p. 112 22. Additional Regulation of Inflammation - p. 114 23. Inflammation and Pain - p. 114 24. Effector Cells of the Acute Inflammatory Response - p. 114 25. Chemical Mediators of the Acute Inflammatory Response - p. 121 26. Reparative Phase of the Acute Inflammatory Response - p. 134 27. Nomenclature of the Inflammatory Response (Morphologic Diagnoses) - p. 135 28. Morphologic Classification of Exudates in Acute Inflammatory Lesions - p. 136 29. Chronic Inflammation - p. 138 30. Beneficial and Harmful Aspects of Chronic Inflammation - p. 139 31. Progression of the Acute Inflammatory Response to Chronic Inflammation, Fibrosis, and Abscess Formation - p. 140 32. Gross and Microscopic Lesions and Nomenclature of the Chronic Inflammatory Response - p. 146 33. Effector Cells and Cellular Mechanisms of Chronic Inflammatory Responses - p. 148 34. Inflammation and the Sensation of Pain - p. 154 35. The Effect of Inflammation on the Febrile Response and Other Activities - p. 154 36. Unique Types of Inflammation - p. 154 37. Cytologic and Histologic Comparisons of Inflammatory Exudates - p. 155 38. Wound Healing and Angiogenesis - p. 157 39. Chapter 4. Mechanisms of Microbial Infections - p. 171 40. Introduction - p. 171 41. Chronologic Sequence of Steps in Microbial Diseases - p. 171 42. Portals of Entry - p. 173 43. Target Cells and Substances - p. 177 44. Pathways of Spread - p. 179 45. Defense Mechanisms - p. 184 46. Genetic Resistance of Animals to Infectious Diseases - p. 188 47. Bacterial Diseases - p. 189 48. Viral Diseases - p. 237 49. Fungal Diseases (Mycoses) - p. 279 50. Protozoan Diseases - p. 287 51. Prion Diseases (Spongiform Encephalopathies) - p. 292 52. Chapter 5. Diseases of Immunity - p. 295 53. General Features of the Immune System - p. 295 54. Innate Immunity (Nonspecific Immunity) - p. 295 55. Adaptive Immunity (Specific Immunity) - p. 299 56. Disorders of the Immune System - p. 313 57. Chapter 6. Neoplasia and Tumor Biology - p. 341 58. Introduction - p. 3411 59. General Nomenclature - p. 3411 60. Tumor Characteristics (Essential Concept 6.1) - p. 345 61. Neoplastic Transformation (Essential Concept 6.2) - p. 352 62. Tumor Microenvironment (Essential Concept 6.3) - p. 354 63. Tumor Immunity (see Essential Concept 6.3) - p. 358 64. Tumor Dissemination (Essential Concept 6.4) - p. 362 65. Systemic Clinical Effects on the Animal (see Essential Concept 6.3) - p. 366 66. Heritable Alterations in Cancer (Essential Concept 6.5) - p. 368 67. Molecular Determinants of Cancer - p. 371 68. Mechanisms of Carcinogenesis - p. 375 69. Cancer in Animals - p. 376 70. Section II. Pathology of Organ Systems - p. 394 71. Introduction - p. 395 72. Chapter 7. Alimentary System and the Peritoneum, Omentum, Mesentery, and Peritoneal Cavity - p. 396 73. Introduction - p. 396 74. Structure and Function - p. 396 75. Dysfunction/Responses to Injury - p. 403 76. Portals of Entry/Pathways of Spread - p. 411 77. Defense Mechanisms/Barrier Systems - p. 415 78. Diseases Affecting Multiple Species of Domestic Animalsc,d - p. 417 79. Diseases of Horses - p. 460 80. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 464 81. Diseases of Pigs - p. 475 82. Diseases of Dogs - p. 480 83. Diseases of Cats - p. 484 84. Chapter 8. Hepatobiliary System and Exocrine Pancreas - p. 486 85. Liver and Intrahepatic Biliary System - p. 486 86. Gallbladder and Extrahepatic Bile Ducts - p. 535 87. Exocrine Pancreas - p. 539 88. Chapter 9. Respiratory System, Thoracic Cavities, Mediastinum, and Pleurae - p. 547 89. Introduction - p. 547 90. Structure and Function - p. 547 91. Dysfunction/Responses to Injury - p. 550 92. Portals of Entry/Pathways of Spread - p. 558 93. Defense Mechanisms/Barrier Systems - p. 558 94. Diseases Affecting Multiple Species of Domestic Animals - p. 563 95. Diseases of Horses - p. 598 96. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 606 97. Diseases of Pigs - p. 624 98. Diseases of Dogs - p. 630 99. Diseases of Cats - p. 638 100. Chapter 10. Cardiovascular System, Pericardial Cavity, and Lymphatic Vessels - p. 643 101. Structure - p. 643 102. Function - p. 647 103. Dysfunction/Responses to Injury - p. 649 104. Portals of Entry/Pathways of Spread - p. 661 105. Defense Mechanisms/Barrier Systems - p. 662 106. Diseases Affecting Multiple Species of Domestic Animals - p. 662 107. Diseases of Horses - p. 685 108. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 687 109. Diseases of Pigs - p. 688 110. Diseases of Dogs - p. 691 111. Diseases of Cats - p. 697 112. Chapter 11. The Urinary System - p. 699 113. Kidney - p. 699 114. Lower Urinary Tract - p. 756 115. Chapter 12. Endocrine System - p. 767 116. Structure and Function - p. 767 117. Dysfunction/Responses to Injury - p. 777 118. Portals of Entry/Pathways of Spread - p. 779 119. Defense Mechanisms/Barrier Systems - p. 779 120. Diseases Affecting Multiple Species of Domestic Animals - p. 780 121. Diseases of Horses - p. 799 122. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 800 123. Diseases of Pigs - p. 801 124. Diseases of Dogs - p. 801 125. Diseases of Cats - p. 805 126. Chapter13. Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic System - p. 809 127. Introduction - p. 809 128. Bone Marrow and Blood Cells - p. 809 129. Chapter 14. Nervous System - p. 892 130. The Nervous System - p. 892 131. Central Nervous System - p. 893 132. Peripheral Nervous System - p. 983 133. Chapter 15. Skeletal Muscle - p. 992 134. Structure - p. 992 135. Function - p. 993 136. Dysfunction/Responses to Injury - p. 997 137. Portals of Entry/Pathways of Spread - p. 1006 138. Defense Mechanisms/Barrier Systems - p. 1007 139. Diseases Affecting Multiple Species of Domestic Animals - p. 1007 140. Diseases of Horses - p. 1016 141. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1024 142. Diseases of Pigs - p. 1028 143. Diseases of Dogs - p. 1029 144. Diseases of Cats - p. 1035 145. Chapter 16. Bones, Joints, Tendons, and Ligaments - p. 1037 146. Introduction - p. 1037 147. Structure and Function - p. 1037 148. Dysfunction/Responses to Injury - p. 1048 149. Portals of Entry/Pathways of Spread - p. 1055 150. Defense Mechanisms/Barrier Systems - p. 1056 151. Diseases Affecting Multiple Species of Domestic Animals - p. 1056 152. Diseases of Horses - p. 1091 153. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1091 154. Diseases of Pigs - p. 1091 155. Diseases of Dogs - p. 1091 156. Diseases of Cats - p. 1094 157. Chapter17. The Integument - p. 1095 158. Structure - p. 1095 159. Function - p. 1107 160. Dysfunction/Responses to Injury - p. 1108 161. Portals of Entry/Pathways of Spread - p. 1146 162. Defense Mechanisms/Barrier Systems - p. 1148 163. Diseases Affecting Multiple Species of Domestic Animals - p. 1149 164. Diseases of Horses - p. 1219 165. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1223 166. Diseases of Pigs - p. 1229 167. Diseases of Dogs - p. 1233 168. Diseases of Cats - p. 1256 169. E-Appendix 17.1. Postmortem Evaluation of the Skin, Claws, Pawpads, and Hooves - p. 1262 170. Chapter 18. Female Reproductive System and Mammae - p. 1263 171. Introduction - p. 1263 172. E-Appendix 18.1 Techniques Used to Examine the Female Reproductive System and Mammae - p. 1263 173. Structure - p. 1263 174. Function - p. 1265 175. Dysfunction/Responses to Injury - p. 1266 176. Portals of Entry/Pathways of Spread - p. 1267 177. Defense Mechanisms/Barrier Systems - p. 1267 178. Diseases Affecting Multiple Species of Domestic Animals - p. 1270 179. Diseases of Horses - p. 1290 180. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1293 181. Diseases of Pigs - p. 1302 182. Diseases of Dogs - p. 1303 183. Diseases of Cats - p. 1307 184. Chapter 19. Male Reproductive System - p. 1308 185. Chapter 20. The Ear - p. 1336 186. Chapter 21. The Eye - p. 1379 187. Introduction - p. 1381 188. Structure and Function - p. 1381 189. Dysfunction/Response to Injury - p. 1387 190. Portals of Entry/Pathways of Spread - p. 1397 191. Defense Mechanisms/Barrier Systems - p. 1399 192. Diseases Affecting Multiple Species of Domestic Animals - p. 1401 193. Diseases of Horses - p. 1424 194. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1426 195. Diseases of Pigs - p. 1427 196. Diseases of Dogs - p. 1427 197. Diseases of Cats - p. 1431 198. E-Appendix 21.1 Postmortem Technique - p. 1433 199. Section III: Appendices, Veterinary Diagnostic Pathology - p. 1433.e1 200. Introduction - p. 1435 201. Appendix A. Communication, Collaboration, and Consultation in Veterinary Pathology - p. e1 202. Appendix B. Photographic Techniques in Veterinary Pathology - p. e15 203. Appendix C. Postmortem Examination (Autopsy) of Domestic Animal Species - p. e23 204. Appendix D. Recognition and Interpretation of Macroscopic (Gross) Lesions - p. e43 205. Appendix E. Diagnoses in Veterinary Pathology - p. e85 206. Appendix F. General Principles of Tissue Fixation and Processing - p. e87 207. Appendix G. Fixatives and Fixation - p. e94 208. Appendix H. Fixation and Trimming of the Brain, Spinal Cord, and Nerves - p. e98 209. Appendix I. Surgical Biopsies—Procurement, Processing, and Sectioning Artifacts - p. e104 210. Appendix J. Gross Examination and Infusion Fixation of the Lung - p. e105 211. Appendix K. Necropsy Techniques by Organ System - p. e109 212. Index - p. 1437