Peptide Chemical Tools for Modulating Biology, Volume 698 in the esteemed Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting topics on Peptide tools that target telomere maintenance, Molecular Design of Peptide Therapeutics, Sulfonyl peptide tools for modulating biology, Peptide tools for targeting the Crk/CrkL-p130Cas axis, Quorum sensing peptide tools, In vivo stability and BBB penetration of peptide tools, and Oligo-benzamide-based peptide mimicking tools for modulating biology.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Series Page - p. iii 5. Copyright - p. iii 6. Contributors - p. iii 7. Chapter One: Synthesis, derivatization, and conformational scanning of peptides containing N-Aminoglycine - p. 2 8. Chapter Two: Thioimidates provide general access to thioamide, amidine, and imidazolone peptide-bond isosteres - p. 28 9. Chapter Three: A single backbone amide modification method to achieve single site-specific chemical protein conjugation - p. 59 10. Chapter Four: Chemical cyclization of tyrosine-containing peptides via in situ generated triazolinedione peptides - p. 90 11. Chapter Five: Highly selective chemical modification of poly-His tagged peptides and proteins - p. 113 12. Chapter Six: Tetrazine cyclized peptides for one-bead-one-compound library: Synthesis and sequencing - p. 142 13. Chapter Seven: One-pot ligation of multiple peptide segments via N-terminal thiazolidine deprotection chemistry - p. 170 14. Chapter Eight: Molecular design of peptide therapeutics via N-terminal modification - p. 196 15. Chapter Nine: Oligo-benzamide-based peptide mimicking tools for modulating biology - p. 222 16. Chapter Ten: Sulfonyl γ-AApeptide tools for modulating biology - p. 248 17. Chapter Eleven: Designing and synthesizing peptide-based quorum sensing modulators - p. 264 18. Chapter Twelve: Use of phosphotyrosine-containing peptides to target SH2 domains: Antagonist peptides of the Crk/CrkL-p130Cas axis - p. 303 19. Chapter Thirteen: Design and synthesis of oxytocin glycosides for the treatment of pain and substance use disorder - p. 344 20. Chapter Fourteen: Fluorescence polarization assay for screening FANCM-RMI inhibitors to target the alternative lengthening of telomeres - p. 362
Peptide Chemical Tools for Modulating Biology, Volume 698 in the esteemed Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting topics on Peptide tools that target telomere maintenance, Molecular Design of Peptide Therapeutics, Sulfonyl peptide tools for modulating biology, Peptide tools for targeting the Crk/CrkL-p130Cas axis, Quorum sensing peptide tools, In vivo stability and BBB penetration of peptide tools, and Oligo-benzamide-based peptide mimicking tools for modulating biology.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Series Page - p. iii 5. Copyright - p. iii 6. Contributors - p. iii 7. Chapter One: Synthesis, derivatization, and conformational scanning of peptides containing N-Aminoglycine - p. 2 8. Chapter Two: Thioimidates provide general access to thioamide, amidine, and imidazolone peptide-bond isosteres - p. 28 9. Chapter Three: A single backbone amide modification method to achieve single site-specific chemical protein conjugation - p. 59 10. Chapter Four: Chemical cyclization of tyrosine-containing peptides via in situ generated triazolinedione peptides - p. 90 11. Chapter Five: Highly selective chemical modification of poly-His tagged peptides and proteins - p. 113 12. Chapter Six: Tetrazine cyclized peptides for one-bead-one-compound library: Synthesis and sequencing - p. 142 13. Chapter Seven: One-pot ligation of multiple peptide segments via N-terminal thiazolidine deprotection chemistry - p. 170 14. Chapter Eight: Molecular design of peptide therapeutics via N-terminal modification - p. 196 15. Chapter Nine: Oligo-benzamide-based peptide mimicking tools for modulating biology - p. 222 16. Chapter Ten: Sulfonyl γ-AApeptide tools for modulating biology - p. 248 17. Chapter Eleven: Designing and synthesizing peptide-based quorum sensing modulators - p. 264 18. Chapter Twelve: Use of phosphotyrosine-containing peptides to target SH2 domains: Antagonist peptides of the Crk/CrkL-p130Cas axis - p. 303 19. Chapter Thirteen: Design and synthesis of oxytocin glycosides for the treatment of pain and substance use disorder - p. 344 20. Chapter Fourteen: Fluorescence polarization assay for screening FANCM-RMI inhibitors to target the alternative lengthening of telomeres - p. 362
