Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury.
In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xiii 6. Preface - p. xvii 7. Section I. Amniotic Fluid-Derived Stem Cells - p. xx 8. Chapter 1. In Utero Therapy for Congenital Disorders Using Amniotic Fluid Stem Cells - p. 3 9. Chapter 2. The Amniotic Fluid Stem Cell Secretome: At the Heart of Repair and Regeneration - p. 21 10. Chapter 3. Transplantation of Amniotic Fluid–Derived Neural Stem Cells - p. 39 11. Chapter 4. Stroke Therapy: The Potential of Amniotic Fluid–Derived Stem Cells - p. 53 12. Chapter 5. Vascular Formation by Perinatal Stem Cells - p. 65 13. Chapter 6. Amniotic Fluid Stem Cells for Kidney Regeneration - p. 85 14. Section II. Placental and Placental Membrane-Derived Stem Cells - p. 95 15. Chapter 7. Mending Broken Hearts: Placenta-Derived Stem Cells for Cardiomyoplasty - p. 99 16. Chapter 8. Heterogeneous Functions of Perinatal Mesenchymal Stromal Cells Require a Preselection Before Their Banking for Clinical Use - p. 117 17. Chapter 9. Fetal Endothelial Progenitors and Mesenchymal Stem Cells From the Human Term Placenta - p. 131 18. Chapter 10. Cotransplantation of Autologous Perinatal Hematopoietic and Mesenchymal Stem Cells for Pediatric Patients With Very Severe Aplastic Anemia - p. 141 19. Chapter 11. Epithelial and Mesenchymal Stromal Cells From the Amniotic Membrane: Both Potent Immunomodulators - p. 147 20. Chapter 12. Bioactive Placental Tissue Matrices Modulate Stem Cell Activity to Promote Healing - p. 157 21. Chapter 13. Perinatal Cells and Biomaterials for Wound Healing - p. 175 22. Chapter 14. Stem Cells Derived From the Placental Villi - p. 187 23. Chapter 15. Therapeutic Effect of Extracellular Vesicles Derived From Adult/Perinatal Human Mesenchymal Stem Cells - p. 201 24. Section III. Umbilical Cord-Derived Cells - p. 215 25. Chapter 16. Umbilical Cord Blood Expansion as an Alternate Graft Source for HSC Transplantation - p. 219 26. Chapter 17. Cord Blood Transplantation: Therapeutic Use of Perinatal Stem Cells - p. 239 27. Chapter 18. Human Umbilical Cord as Treatment for Traumatic Brain Injury in Children - p. 249 28. Chapter 19. Perinatal Stem Cells Isolated From Complete Umbilical Cord Tissue for Family Stem Cell Banking and Potential Therapeutic Use - p. 257 29. Chapter 20. Mesenchymal Stromal Cells From Wharton's Jelly (WJ-MSCs): Coupling Their Hidden Differentiative Program to Their Frank Immunomodulatory Phenotype - p. 271 30. Chapter 21. Regeneration of Ischemic Cardiovascular Damage Using Wharton's Jelly as an Unlimited Source of Therapeutic Stem Cells - p. 281 31. Chapter 22. Phenotype With Focused Paracrine Fractions: Effecting Future Phenotype With Focused Paracrine Fractions - p. 291 32. Section IV. Clinical and Industry Perspective - p. 301 33. Chapter 23. Potential of Clinical Application of Human Amniotic Epithelial Cells for Liver Diseases - p. 305 34. Chapter 24. Clinical Trials and Family Banking of Perinatal Stem Cells - p. 321 35. Chapter 25. Review of Processing Technology and Techniques for Perinatal Stem Cells Banking and Clinical Applications - p. 337 36. Chapter 26. Clinical Development and Commercialization of Placenta-Derived Cell Therapy - p. 357 37. Chapter 27. Patent Protection of Stem Cell Innovations - p. 377 38. Chapter 28. Dose Determination for Stem Cell Medicine: A Need Whose Time Has Come - p. 383 39. Index - p. 399
Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury.
In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xiii 6. Preface - p. xvii 7. Section I. Amniotic Fluid-Derived Stem Cells - p. xx 8. Chapter 1. In Utero Therapy for Congenital Disorders Using Amniotic Fluid Stem Cells - p. 3 9. Chapter 2. The Amniotic Fluid Stem Cell Secretome: At the Heart of Repair and Regeneration - p. 21 10. Chapter 3. Transplantation of Amniotic Fluid–Derived Neural Stem Cells - p. 39 11. Chapter 4. Stroke Therapy: The Potential of Amniotic Fluid–Derived Stem Cells - p. 53 12. Chapter 5. Vascular Formation by Perinatal Stem Cells - p. 65 13. Chapter 6. Amniotic Fluid Stem Cells for Kidney Regeneration - p. 85 14. Section II. Placental and Placental Membrane-Derived Stem Cells - p. 95 15. Chapter 7. Mending Broken Hearts: Placenta-Derived Stem Cells for Cardiomyoplasty - p. 99 16. Chapter 8. Heterogeneous Functions of Perinatal Mesenchymal Stromal Cells Require a Preselection Before Their Banking for Clinical Use - p. 117 17. Chapter 9. Fetal Endothelial Progenitors and Mesenchymal Stem Cells From the Human Term Placenta - p. 131 18. Chapter 10. Cotransplantation of Autologous Perinatal Hematopoietic and Mesenchymal Stem Cells for Pediatric Patients With Very Severe Aplastic Anemia - p. 141 19. Chapter 11. Epithelial and Mesenchymal Stromal Cells From the Amniotic Membrane: Both Potent Immunomodulators - p. 147 20. Chapter 12. Bioactive Placental Tissue Matrices Modulate Stem Cell Activity to Promote Healing - p. 157 21. Chapter 13. Perinatal Cells and Biomaterials for Wound Healing - p. 175 22. Chapter 14. Stem Cells Derived From the Placental Villi - p. 187 23. Chapter 15. Therapeutic Effect of Extracellular Vesicles Derived From Adult/Perinatal Human Mesenchymal Stem Cells - p. 201 24. Section III. Umbilical Cord-Derived Cells - p. 215 25. Chapter 16. Umbilical Cord Blood Expansion as an Alternate Graft Source for HSC Transplantation - p. 219 26. Chapter 17. Cord Blood Transplantation: Therapeutic Use of Perinatal Stem Cells - p. 239 27. Chapter 18. Human Umbilical Cord as Treatment for Traumatic Brain Injury in Children - p. 249 28. Chapter 19. Perinatal Stem Cells Isolated From Complete Umbilical Cord Tissue for Family Stem Cell Banking and Potential Therapeutic Use - p. 257 29. Chapter 20. Mesenchymal Stromal Cells From Wharton's Jelly (WJ-MSCs): Coupling Their Hidden Differentiative Program to Their Frank Immunomodulatory Phenotype - p. 271 30. Chapter 21. Regeneration of Ischemic Cardiovascular Damage Using Wharton's Jelly as an Unlimited Source of Therapeutic Stem Cells - p. 281 31. Chapter 22. Phenotype With Focused Paracrine Fractions: Effecting Future Phenotype With Focused Paracrine Fractions - p. 291 32. Section IV. Clinical and Industry Perspective - p. 301 33. Chapter 23. Potential of Clinical Application of Human Amniotic Epithelial Cells for Liver Diseases - p. 305 34. Chapter 24. Clinical Trials and Family Banking of Perinatal Stem Cells - p. 321 35. Chapter 25. Review of Processing Technology and Techniques for Perinatal Stem Cells Banking and Clinical Applications - p. 337 36. Chapter 26. Clinical Development and Commercialization of Placenta-Derived Cell Therapy - p. 357 37. Chapter 27. Patent Protection of Stem Cell Innovations - p. 377 38. Chapter 28. Dose Determination for Stem Cell Medicine: A Need Whose Time Has Come - p. 383 39. Index - p. 399
