Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices.
Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists.
1. Pharmacokinetics and Toxicokinetic Considerations - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Dedication - p. Page v 7. Contents - p. Page vii 8. List of contributors - p. Page viii 9. List of Illustrations - p. Page ix 10. List of Tables - p. Page x 11. Chapter 1 : Principles and concepts in toxicokinetic - p. Page x 12. Chapter 2 : Factors influencing drug toxicity - p. Page 21 13. Chapter 3 : Molecular biology of apoptotic, necrotic, and necroptotic cell death - p. Page 45 14. Chapter 4 : Toxicogenomics in drug safety assessment - p. Page 68 15. Chapter 5 : Understanding the concept of signal toxicity and its implications on human health - p. Page 91 16. Chapter 6 : Importance of toxicity testing in drug discovery and research - p. Page 113 17. Chapter 7 : Methods and models for in vitro toxicity - p. Page 139 18. Chapter 8 : New emerging technologies for genetic toxicity testing - p. Page 168 19. Chapter 9 : Zebrafish models for toxicological screening - p. Page 214 20. Chapter 10 : Impact of ageing on the pharmacokinetics and pharmacodynamics of the drugs - p. Page 236 21. Chapter 11 : Food–drug interactions and their implications on oral drug bioavailability - p. Page 255 22. Chapter 12 : Drug–drug interactions and their implications on the pharmacokinetics of the drugs - p. Page 283 23. Chapter 13 : Clinical importance of herb–drug interaction - p. Page 317 24. Chapter 14 : In silico methods for the prediction of drug toxicity - p. Page 350 25. Chapter 15 : Organ-on-chip for assessing environmental toxicants - p. Page 376 26. Chapter 16 : Toxicity and toxicokinetic considerations in product development and drug research - p. Page 397 27. Chapter 17 : Drug toxicity and forensic pharmacokinetics - p. Page 420 28. Chapter 18 : Excipient toxicity and safety - p. Page 478 29. Chapter 19 : Pharmaceutical excipients: special focus on adverse interactions - p. Page 507 30. Chapter 20 : Emerging role of novel excipients in drug product development and their safety concerns - p. Page 538 31. Chapter 21 : Toxicity of pharmaceutical azo dyes - p. Page 565 32. Chapter 22 : Environmental and safety aspects of bionanotechnology - p. Page 598 33. Chapter 23 : Toxicological assessment of risk of medical devices - p. Page 640 34. Chapter 24 : Developmental toxicity of nanomaterials used in drug delivery: understanding molecular biomechanics and potential remedial measures - p. Page 681 35. Chapter 25 : Ethical defilements in clinical research and potential roles of institutional review board - p. Page 718 36. Chapter 26 : Toxicokinetic and toxicodynamic considerations in drug research - p. Page 748 37. Index - p. Page 770
Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices.
Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists.
1. Pharmacokinetics and Toxicokinetic Considerations - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Dedication - p. Page v 7. Contents - p. Page vii 8. List of contributors - p. Page viii 9. List of Illustrations - p. Page ix 10. List of Tables - p. Page x 11. Chapter 1 : Principles and concepts in toxicokinetic - p. Page x 12. Chapter 2 : Factors influencing drug toxicity - p. Page 21 13. Chapter 3 : Molecular biology of apoptotic, necrotic, and necroptotic cell death - p. Page 45 14. Chapter 4 : Toxicogenomics in drug safety assessment - p. Page 68 15. Chapter 5 : Understanding the concept of signal toxicity and its implications on human health - p. Page 91 16. Chapter 6 : Importance of toxicity testing in drug discovery and research - p. Page 113 17. Chapter 7 : Methods and models for in vitro toxicity - p. Page 139 18. Chapter 8 : New emerging technologies for genetic toxicity testing - p. Page 168 19. Chapter 9 : Zebrafish models for toxicological screening - p. Page 214 20. Chapter 10 : Impact of ageing on the pharmacokinetics and pharmacodynamics of the drugs - p. Page 236 21. Chapter 11 : Food–drug interactions and their implications on oral drug bioavailability - p. Page 255 22. Chapter 12 : Drug–drug interactions and their implications on the pharmacokinetics of the drugs - p. Page 283 23. Chapter 13 : Clinical importance of herb–drug interaction - p. Page 317 24. Chapter 14 : In silico methods for the prediction of drug toxicity - p. Page 350 25. Chapter 15 : Organ-on-chip for assessing environmental toxicants - p. Page 376 26. Chapter 16 : Toxicity and toxicokinetic considerations in product development and drug research - p. Page 397 27. Chapter 17 : Drug toxicity and forensic pharmacokinetics - p. Page 420 28. Chapter 18 : Excipient toxicity and safety - p. Page 478 29. Chapter 19 : Pharmaceutical excipients: special focus on adverse interactions - p. Page 507 30. Chapter 20 : Emerging role of novel excipients in drug product development and their safety concerns - p. Page 538 31. Chapter 21 : Toxicity of pharmaceutical azo dyes - p. Page 565 32. Chapter 22 : Environmental and safety aspects of bionanotechnology - p. Page 598 33. Chapter 23 : Toxicological assessment of risk of medical devices - p. Page 640 34. Chapter 24 : Developmental toxicity of nanomaterials used in drug delivery: understanding molecular biomechanics and potential remedial measures - p. Page 681 35. Chapter 25 : Ethical defilements in clinical research and potential roles of institutional review board - p. Page 718 36. Chapter 26 : Toxicokinetic and toxicodynamic considerations in drug research - p. Page 748 37. Index - p. Page 770
