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Pharmacology and physiology are the foundation of every anesthesia provider’s training and clinical competency. Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application, 2nd Edition, delivers the information you need in pharmacology, physiology, and molecular-cellular biology, keeping you current with contemporary training and practice. This thoroughly updated edition is your one-stop, comprehensive overview of physiology, and rational anesthetic drug selection and administration, perfect for study, review, and successful practice.

  • Contains new chapters on Special Populations (anesthetic pharmacology in obesity, geriatrics, and pediatrics), Oral and Non-IV Opioids, Thermoregulation, Physiology and Pharmacology of Obstetric Anesthesia, Chemotherapeutic and Immunosuppresive Drugs, and Surgical Infection and Antimicrobial Drugs.
  • Incorporates entirely new sections on Physics, Anatomy, and Imaging.
  • Includes new information on consciousness and cognition, pharmacodynamics, the immune system, and anti-inflammatory drugs.
  • Features user-friendly tables, figures, and algorithms (including 100 new illustrations), all presented in full color and designed to help explain complex concepts.
  • Helps you understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these areas.

1. Introduction - p. 1 2. 1 Mechanisms of Drug Action - p. 2 3. 2 Pharmacokinetic and Pharmacodynamic Principles for Intravenous Anesthetics - p. 20 4. 3 Pharmacokinetics of Inhaled Anesthetics - p. 44 5. 4 Drug Metabolism and Pharmacogenetics - p. 70 6. 5 Physiology and Pharmacology of Obesity, Pediatrics, and the Elderly - p. 91 7. 6 Pharmacodynamic Drug Interactions - p. 113 8. 7 Adverse Drug Reactions - p. 130 9. Section II Nervous System - p. 143 10. Introduction - p. 144 11. 8 Central Nervous System Physiology - p. 145 12. 9 Central Nervous System Physiology - p. 174 13. 10 Pharmacology of Intravenous Anesthetics - p. 193 14. 11 Pharmacology of Inhaled Anesthetics - p. 217 15. 12 Drugs for Neuropsychiatric Disorders - p. 241 16. 13 Autonomic Nervous System - p. 270 17. 14 Autonomic Nervous System Pharmacology - p. 282 18. 15 Thermoregulation - p. 300 19. 16 Nociceptive Physiology - p. 311 20. 17 Intravenous Opioid Agonists and Antagonists - p. 332 21. 18 Nonintravenous Opioids - p. 354 22. 19 Nonopioid Analgesics - p. 369 23. 20 Local Anesthetics - p. 390 24. 21 Neuromuscular Physiology and Pharmacology - p. 412 25. 22 Neuromuscular Blockers and Reversal Drugs - p. 428 26. Section III Cardiovascular System - p. 454 27. Introduction - p. 455 28. 23 Cardiovascular Physiology - p. 456 29. 24 Cardiovascular Physiology - p. 473 30. 25 Vasopressors and Inotropes - p. 520 31. 26 Antihypertensive Drugs and Vasodilators - p. 535 32. 27 Antiarrhythmic Drugs - p. 556 33. 28 Cardiopulmonary Resuscitation - p. 575 34. Section IV Pulmonary System - p. 584 35. Introduction - p. 585 36. 29 Pulmonary Physiology - p. 586 37. 30 Pulmonary Pharmacology - p. 613 38. Section V Gastrointestinal and Endocrine Systems - p. 628 39. Introduction - p. 629 40. 31 Liver and Gastrointestinal Physiology - p. 630 41. 32 Liver and Gastrointestinal Pharmacology - p. 645 42. 33 Nutritional and Metabolic Therapy - p. 657 43. 34 Pharmacology of Postoperative Nausea and Vomiting - p. 671 44. 35 Endocrine Physiology - p. 693 45. 36 Endocrine Pharmacology - p. 708 46. 37 Physiology and Pharmacology of Obstetric Anesthesia - p. 732 47. Section VI Immunity and Infection - p. 751 48. Introduction - p. 752 49. 38 Chemotherapy, Immunosuppression, and Anesthesia - p. 753 50. 39 Infection, Antimicrobial Drugs, and Anesthesia - p. 769 51. Section VII Fluid, Electrolyte, and Hematologic Homeostasis - p. 780 52. Introduction - p. 781 53. 40 Renal Physiology - p. 782 54. 41 Intravascular Volume Replacement Therapy - p. 795 55. 42 Electrolytes and Diuretics - p. 814 56. Section VIII Blood and Hemostasis - p. 835 57. Introduction - p. 836 58. 43 Blood and Coagulation - p. 837 59. 44 Transfusion and Coagulation Therapy - p. 849 60. 45 Anticoagulant and Antiplatelet Therapy - p. 870 61. Index - p. 895

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Pharmacology and physiology are the foundation of every anesthesia provider’s training and clinical competency. Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application, 2nd Edition, delivers the information you need in pharmacology, physiology, and molecular-cellular biology, keeping you current with contemporary training and practice. This thoroughly updated edition is your one-stop, comprehensive overview of physiology, and rational anesthetic drug selection and administration, perfect for study, review, and successful practice.

  • Contains new chapters on Special Populations (anesthetic pharmacology in obesity, geriatrics, and pediatrics), Oral and Non-IV Opioids, Thermoregulation, Physiology and Pharmacology of Obstetric Anesthesia, Chemotherapeutic and Immunosuppresive Drugs, and Surgical Infection and Antimicrobial Drugs.
  • Incorporates entirely new sections on Physics, Anatomy, and Imaging.
  • Includes new information on consciousness and cognition, pharmacodynamics, the immune system, and anti-inflammatory drugs.
  • Features user-friendly tables, figures, and algorithms (including 100 new illustrations), all presented in full color and designed to help explain complex concepts.
  • Helps you understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these areas.

1. Introduction - p. 1 2. 1 Mechanisms of Drug Action - p. 2 3. 2 Pharmacokinetic and Pharmacodynamic Principles for Intravenous Anesthetics - p. 20 4. 3 Pharmacokinetics of Inhaled Anesthetics - p. 44 5. 4 Drug Metabolism and Pharmacogenetics - p. 70 6. 5 Physiology and Pharmacology of Obesity, Pediatrics, and the Elderly - p. 91 7. 6 Pharmacodynamic Drug Interactions - p. 113 8. 7 Adverse Drug Reactions - p. 130 9. Section II Nervous System - p. 143 10. Introduction - p. 144 11. 8 Central Nervous System Physiology - p. 145 12. 9 Central Nervous System Physiology - p. 174 13. 10 Pharmacology of Intravenous Anesthetics - p. 193 14. 11 Pharmacology of Inhaled Anesthetics - p. 217 15. 12 Drugs for Neuropsychiatric Disorders - p. 241 16. 13 Autonomic Nervous System - p. 270 17. 14 Autonomic Nervous System Pharmacology - p. 282 18. 15 Thermoregulation - p. 300 19. 16 Nociceptive Physiology - p. 311 20. 17 Intravenous Opioid Agonists and Antagonists - p. 332 21. 18 Nonintravenous Opioids - p. 354 22. 19 Nonopioid Analgesics - p. 369 23. 20 Local Anesthetics - p. 390 24. 21 Neuromuscular Physiology and Pharmacology - p. 412 25. 22 Neuromuscular Blockers and Reversal Drugs - p. 428 26. Section III Cardiovascular System - p. 454 27. Introduction - p. 455 28. 23 Cardiovascular Physiology - p. 456 29. 24 Cardiovascular Physiology - p. 473 30. 25 Vasopressors and Inotropes - p. 520 31. 26 Antihypertensive Drugs and Vasodilators - p. 535 32. 27 Antiarrhythmic Drugs - p. 556 33. 28 Cardiopulmonary Resuscitation - p. 575 34. Section IV Pulmonary System - p. 584 35. Introduction - p. 585 36. 29 Pulmonary Physiology - p. 586 37. 30 Pulmonary Pharmacology - p. 613 38. Section V Gastrointestinal and Endocrine Systems - p. 628 39. Introduction - p. 629 40. 31 Liver and Gastrointestinal Physiology - p. 630 41. 32 Liver and Gastrointestinal Pharmacology - p. 645 42. 33 Nutritional and Metabolic Therapy - p. 657 43. 34 Pharmacology of Postoperative Nausea and Vomiting - p. 671 44. 35 Endocrine Physiology - p. 693 45. 36 Endocrine Pharmacology - p. 708 46. 37 Physiology and Pharmacology of Obstetric Anesthesia - p. 732 47. Section VI Immunity and Infection - p. 751 48. Introduction - p. 752 49. 38 Chemotherapy, Immunosuppression, and Anesthesia - p. 753 50. 39 Infection, Antimicrobial Drugs, and Anesthesia - p. 769 51. Section VII Fluid, Electrolyte, and Hematologic Homeostasis - p. 780 52. Introduction - p. 781 53. 40 Renal Physiology - p. 782 54. 41 Intravascular Volume Replacement Therapy - p. 795 55. 42 Electrolytes and Diuretics - p. 814 56. Section VIII Blood and Hemostasis - p. 835 57. Introduction - p. 836 58. 43 Blood and Coagulation - p. 837 59. 44 Transfusion and Coagulation Therapy - p. 849 60. 45 Anticoagulant and Antiplatelet Therapy - p. 870 61. Index - p. 895

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