Placebo Effects in Neurology delves into the intriguing phenomenon of placebos and their profound impact on neurological disorders. This book explores how placebo effects, occurring both in clinical trials and real-world practice, influence therapeutic outcomes, doctor-patient relationships, and symptom perception. The content provides insights into psychobiological mechanisms and specific conditions such as Parkinson’s disease and migraine while addressing ethical and methodological concerns. With discussions on both deceptive and open-label placebos, the book invites readers to reconsider the potential of this underappreciated tool in neurology, offering a bridge between scientific research and practical application in the treatment of various conditions.
Beyond its focus on placebo mechanisms, the book examines their role in alleviating symptoms of neuropathic pain, peripheral neuropathies, fatigue, and neuropsychiatric disorders like depression and anxiety. It also presents a methodological lens on how placebos are used to validate treatments in trials while debating their ethical implications. By weaving together science, ethics, and practical insights, Placebo Effects in Neurology stands out as a compelling resource for clinicians, researchers, and anyone interested in the nuanced intersection of psychology and neurology.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. ii 5. Copyright - p. ii 6. Handbook of Clinical Neurology 3rd Series - p. ii 7. Foreword - p. ii 8. Preface - p. ii 9. List of contributors - p. ii 10. SECTION I General considerations - p. ii 11. Chapter 1: A brief history of placebo - p. 3 12. Chapter 2: Placebo effects and emotion regulation: conceptual and neural similarities and differences - p. 17 13. Chapter 3: Understanding the psychology of the nocebo effect - p. 31 14. Chapter 4: Open-label nondeceptive placebos - p. 51 15. Chapter 5: The role of observational learning in the formation of placebo and nocebo effects - p. 59 16. Chapter 6: Age and gender - p. 71 17. Chapter 7: Conditioned immune responses and the neural-immune connection in animals and humans - p. 83 18. Chapter 8: The role of mindsets in placebo effects and healthcare - p. 99 19. Chapter 9: The placebome - p. 115 20. SECTION II Specific neurologic conditions - p. 123 21. Chapter 10: Placebo and nocebo effect in pain - p. 129 22. Chapter 11: The motor system and motor disorders - p. 147 23. Chapter 12: Peripheral neuropathies - p. 165 24. Chapter 13: Placebo and nocebo effects in headaches - p. 175 25. Chapter 14: Placebo effects in mental disorders - p. 183 26. Chapter 15: Miscellaneous neurologic conditions with a few or no available data - p. 195 27. Chapter 16: Hypoxia - p. 209 28. Chapter 17: The placebo effect in psychotherapy - p. 225 29. Chapter 18: Interventional procedures and physical therapies - p. 235 30. Chapter 19: The COVID-19 pandemic: a special case of placebo and nocebo effects - p. 247 31. SECTION III Methodological and ethical issues - p. 258 32. Chapter 20: Minimizing placebo responses in clinical trials - p. 265 33. Chapter 21: Ethical considerations with using placebo treatments and effects in clinical practice - p. 277 34. Chapter 22: Placebo and the doctor–patient interaction and communication - p. 289 35. Index - p. 299
Placebo Effects in Neurology delves into the intriguing phenomenon of placebos and their profound impact on neurological disorders. This book explores how placebo effects, occurring both in clinical trials and real-world practice, influence therapeutic outcomes, doctor-patient relationships, and symptom perception. The content provides insights into psychobiological mechanisms and specific conditions such as Parkinson’s disease and migraine while addressing ethical and methodological concerns. With discussions on both deceptive and open-label placebos, the book invites readers to reconsider the potential of this underappreciated tool in neurology, offering a bridge between scientific research and practical application in the treatment of various conditions.
Beyond its focus on placebo mechanisms, the book examines their role in alleviating symptoms of neuropathic pain, peripheral neuropathies, fatigue, and neuropsychiatric disorders like depression and anxiety. It also presents a methodological lens on how placebos are used to validate treatments in trials while debating their ethical implications. By weaving together science, ethics, and practical insights, Placebo Effects in Neurology stands out as a compelling resource for clinicians, researchers, and anyone interested in the nuanced intersection of psychology and neurology.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. ii 5. Copyright - p. ii 6. Handbook of Clinical Neurology 3rd Series - p. ii 7. Foreword - p. ii 8. Preface - p. ii 9. List of contributors - p. ii 10. SECTION I General considerations - p. ii 11. Chapter 1: A brief history of placebo - p. 3 12. Chapter 2: Placebo effects and emotion regulation: conceptual and neural similarities and differences - p. 17 13. Chapter 3: Understanding the psychology of the nocebo effect - p. 31 14. Chapter 4: Open-label nondeceptive placebos - p. 51 15. Chapter 5: The role of observational learning in the formation of placebo and nocebo effects - p. 59 16. Chapter 6: Age and gender - p. 71 17. Chapter 7: Conditioned immune responses and the neural-immune connection in animals and humans - p. 83 18. Chapter 8: The role of mindsets in placebo effects and healthcare - p. 99 19. Chapter 9: The placebome - p. 115 20. SECTION II Specific neurologic conditions - p. 123 21. Chapter 10: Placebo and nocebo effect in pain - p. 129 22. Chapter 11: The motor system and motor disorders - p. 147 23. Chapter 12: Peripheral neuropathies - p. 165 24. Chapter 13: Placebo and nocebo effects in headaches - p. 175 25. Chapter 14: Placebo effects in mental disorders - p. 183 26. Chapter 15: Miscellaneous neurologic conditions with a few or no available data - p. 195 27. Chapter 16: Hypoxia - p. 209 28. Chapter 17: The placebo effect in psychotherapy - p. 225 29. Chapter 18: Interventional procedures and physical therapies - p. 235 30. Chapter 19: The COVID-19 pandemic: a special case of placebo and nocebo effects - p. 247 31. SECTION III Methodological and ethical issues - p. 258 32. Chapter 20: Minimizing placebo responses in clinical trials - p. 265 33. Chapter 21: Ethical considerations with using placebo treatments and effects in clinical practice - p. 277 34. Chapter 22: Placebo and the doctor–patient interaction and communication - p. 289 35. Index - p. 299
