Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles.
Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles – such as mucosal and transdermal – and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation.
1. Curatives and Crosslinkers - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. List of contributors - p. xxi 8. About the editors - p. xxv 9. Preface - p. xxv 10. Acknowledgments - p. xxix 11. Chapter 1 Polymeric micelles: précis for past, present and future - p. 3 12. Chapter 2 Various polymers in the development of polymeric micelles - p. 15 13. Chapter 3 Solubility enhancement and drug release mechanism of polymeric micelles - p. 41 14. Chapter 4 Polymeric micellar nanomedicine for enhanced permeability and retention effect–based tumor-targeted delivery - p. 65 15. Chapter 5 Polymeric micelles for oral drug delivery - p. 89 16. Chapter 6 Polymeric micellar nanocarriers: topical treatment of inflammatory diseases - p. 115 17. Chapter 7 Polymeric micelles in dermal and transdermal drug delivery - p. 147 18. Chapter 8 Polymeric micelles as delivery systems for anticancer immunotherapy - p. 175 19. Chapter 9 Polymeric micelles for drug delivery in oncology with an emphasis on siRNA conveyance - p. 199 20. Chapter 10 Surface engineering of polymeric micelles for imparting multifunctionality - p. 285 21. Chapter 11 Cellular interaction of polymeric micelles in targeted drug delivery systems: the road from tissue to cell - p. 315 22. Chapter 12 pH-responsive polymeric micelles for drug delivery - p. 349 23. Chapter 13 Enzyme-responsive polymeric micelles for drug delivery applications - p. 367 24. Chapter 14 Light- and temperature-responsive polymeric micelles for drug delivery - p. 395 25. Chapter 15 Exogenous stimuli–responsive polymeric micelles for drug delivery - p. 409 26. Chapter 16 Dual-responsive polymeric micelles for drug delivery - p. 429 27. Chapter 17 Polymeric micelles for drug codelivery - p. 451 28. Chapter 18 Nose-to-brain delivery - p. 479 29. Chapter 19 The application of a drug–poly(lactic-co-glycolic acid) hybrid micellar system for drug delivery - p. 497 30. Chapter 20 Polymeric micelles with cleavable links for drug delivery - p. 515 31. Chapter 21 Block copolymer micelles as long-circulating drug delivery vehicles - p. 531 32. Chapter 22 Triblock polymeric micelles as an emerging nanocarrier for drug delivery - p. 561 33. Chapter 23 Biological toxicity and environmental hazards associated with polymeric micelles - p. 593 34. Chapter 24 Clinical translation of polymeric micelles into market - p. 629 35. Chapter 25 Regulatory pathways and prospects for polymeric micelles - p. 657 36. Index - p. 675
Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles.
Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles – such as mucosal and transdermal – and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation.
1. Curatives and Crosslinkers - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. List of contributors - p. xxi 8. About the editors - p. xxv 9. Preface - p. xxv 10. Acknowledgments - p. xxix 11. Chapter 1 Polymeric micelles: précis for past, present and future - p. 3 12. Chapter 2 Various polymers in the development of polymeric micelles - p. 15 13. Chapter 3 Solubility enhancement and drug release mechanism of polymeric micelles - p. 41 14. Chapter 4 Polymeric micellar nanomedicine for enhanced permeability and retention effect–based tumor-targeted delivery - p. 65 15. Chapter 5 Polymeric micelles for oral drug delivery - p. 89 16. Chapter 6 Polymeric micellar nanocarriers: topical treatment of inflammatory diseases - p. 115 17. Chapter 7 Polymeric micelles in dermal and transdermal drug delivery - p. 147 18. Chapter 8 Polymeric micelles as delivery systems for anticancer immunotherapy - p. 175 19. Chapter 9 Polymeric micelles for drug delivery in oncology with an emphasis on siRNA conveyance - p. 199 20. Chapter 10 Surface engineering of polymeric micelles for imparting multifunctionality - p. 285 21. Chapter 11 Cellular interaction of polymeric micelles in targeted drug delivery systems: the road from tissue to cell - p. 315 22. Chapter 12 pH-responsive polymeric micelles for drug delivery - p. 349 23. Chapter 13 Enzyme-responsive polymeric micelles for drug delivery applications - p. 367 24. Chapter 14 Light- and temperature-responsive polymeric micelles for drug delivery - p. 395 25. Chapter 15 Exogenous stimuli–responsive polymeric micelles for drug delivery - p. 409 26. Chapter 16 Dual-responsive polymeric micelles for drug delivery - p. 429 27. Chapter 17 Polymeric micelles for drug codelivery - p. 451 28. Chapter 18 Nose-to-brain delivery - p. 479 29. Chapter 19 The application of a drug–poly(lactic-co-glycolic acid) hybrid micellar system for drug delivery - p. 497 30. Chapter 20 Polymeric micelles with cleavable links for drug delivery - p. 515 31. Chapter 21 Block copolymer micelles as long-circulating drug delivery vehicles - p. 531 32. Chapter 22 Triblock polymeric micelles as an emerging nanocarrier for drug delivery - p. 561 33. Chapter 23 Biological toxicity and environmental hazards associated with polymeric micelles - p. 593 34. Chapter 24 Clinical translation of polymeric micelles into market - p. 629 35. Chapter 25 Regulatory pathways and prospects for polymeric micelles - p. 657 36. Index - p. 675
