Polyphenols in Human Health and Disease documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more.
1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. About the Editors - p. IV 6. List of Contributors - p. XXI 7. Preface - p. XXI 8. Acknowledgments - p. XXXII 9. Volume 1: Polyphenols in Chronic Diseases and their Mechanisms of Action - p. XXXIII 10. Section 1: Overview of Polyphenols and Health - p. XXXIII 11. Chapter 1. Polyphenols in Foods and Dietary Supplements: Role in Veterinary Medicine and Animal Health - p. XXXIII 12. Chapter 2. Polyphenols and Public Health - p. 7 13. Chapter 3. The History of Islamic Medicine at a Glance - p. 14 14. Chapter 4. Polyphenols and Their Formulations: Different Strategies to Overcome the Drawbacks Associated with Their Poor Stability and Bioavailability - p. 26 15. Chapter 5. Biological Activities of Polyphenols from Grapes - p. 43 16. Chapter 6. The Atomic Level Interaction of Polyphenols with the Aβ Oligomer Aggregate, A Molecular Dynamic Guidance for Rational Drug Design - p. 53 17. Chapter 7. Polyphenols as Supplements in Foods and Beverages: Recent Methods, Benefits and Risks - p. 67 18. Section 2: Polyphenols in Therapy of Obesity and Diabetes - p. 76 19. Section 2.1: Polyphenols and Diabetes - p. 76 20. Chapter 8. Anthocyanins and Diabetes Regulation - p. 76 21. Chapter 9. Influence of Dietary Polyphenols on Carbohydrate Metabolism - p. 90 22. Chapter 10. Polyphenols in Ayurvedic Medicine and Type 2 Diabetes - p. 105 23. Chapter 11. Antidiabetic and Anticancer Potential of Native Medicinal Plants from Saudi Arabia - p. 117 24. Section 2.2: Polyphenols and Obesity - p. 130 25. Chapter 12. Prevention of Diet-Induced Obesity by Dietary Polyphenols Derived from Nelumbo nucifera and Black Tea - p. 130 26. Chapter 13. Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids - p. 141 27. Chapter 14. Dietary Quercetin and other Polyphenols: Attenuation of Obesity - p. 156 28. Chapter 15. Role of Protocatechuic Acid in Obesity-Related Pathologies - p. 172 29. Chapter 16. Food and Supplement Polyphenol Action in Cancer Recurrence - p. 184 30. Section 3: Oxidation and Antioxidant Activity of Polyphenols - p. 194 31. Section 3.1: Polyphenolic Antioxidants in Health Promotion - p. 194 32. Chapter 17. Implications of Polyphenols on Endogenous Antioxidant Defense Systems in Human Diseases - p. 194 33. Chapter 18. Potent Antioxidant and Anti-Inflammatory Flavonoids in the Nutrient-Rich Amazonian Palm Fruit, Açaí (Euterpe spp.) - p. 211 34. Chapter 19. Dark Chocolate/Cocoa Polyphenols and Oxidative Stress - p. 236 35. Chapter 20. Polyphenol Antioxidants from Natural Sources and Contribution to Health Promotion - p. 249 36. Chapter 21. Antioxidant Role of Catechin in Health and Disease - p. 263 37. Section 3.2: Mechanisms of Polyphenols’ Antioxidant Effects - p. 270 38. Chapter 22. Cytoprotective Effects of Polyphenols against Oxidative Damage - p. 270 39. Chapter 23. The Role of Direct and Indirect Polyphenolic Antioxidants in Protection Against Oxidative Stress - p. 285 40. Chapter 24. Polyphenols and Low Iron Bioavailability - p. 304 41. Chapter 25. Galloylation and Polymerization: Role of Structure to Antioxidant Activity of Polyphenols in Lipid Systems - p. 319 42. Chapter 26. Chemical Properties, Bioavailability, and Metabolomics of Fruit Proanthocyanidins - p. 336 43. Section 4: Polyphenols in Brain and Neurobiology Health - p. 348 44. Section 4.1: Mechanisms of Polyphenols in Neurobiology - p. 348 45. Chapter 27. Plant Polyphenols as Dietary Modulators of Brain Functions - p. 348 46. Section 5: Inflammation and Polyphenols - p. 365 47. Chapter 28. Anti-Inflammatory Activity of Polyphenols on Dendritic Cells - p. 365 48. Chapter 29. Polyphenols Suppress and Modulate Inflammation: Possible Roles in Health and Disease - p. 389 49. Chapter 30. Anti-Inflammatory Properties of Cinnamon Polyphenols and their Monomeric Precursors - p. 402 50. Chapter 31. Polyphenols in the Prevention of Acute Pancreatitis: Preclinical Observations - p. 421 51. Chapter 32. Anti-Inflammatory and Immunomodulatory Properties of Dietary Flavonoids - p. 432 52. Chapter 33. Immunomodulatory Ethnobotanicals of the Great Lakes - p. 446 53. Chapter 34. Pongamia pinnata (Linn.) Pierre and Inflammation - p. 459 54. Chapter 35. Polyphenol-Mediated Beneficial Effects in Healthy Status and Disease with Special Reference to Immune-Based Mechanisms - p. 465 55. Section 5.1: Bioavailability and Effects on Metabolism - p. 475 56. Chapter 36. Using Recombinant Microorganisms for the Synthesis and Modification of Flavonoids and Stilbenes - p. 475 57. Chapter 37. Bioavailability of Flavonoids: The Role of Cell Membrane Transporters - p. 487 58. Chapter 38. Microorganism Metabolic Activity Stimulation by Polyphenols - p. 504 59. Chapter 39. Interaction of Polyphenols with the Intestinal and Placental Absorption of some Nutrients and other Compounds - p. 520 60. Chapter 40. Bioavailability and Metabolism of Citrus Fruit Beverage Flavanones in Humans - p. 532 61. Chapter 41. Uptake and Metabolism of Dietary Proanthocyanidins - p. 547 62. Chapter 42. Bioavailability of Dietary Anthocyanins and Hydroxycinnamic Acids - p. 558 63. Chapter 43. Microbial Metabolism of Polyphenols and Health - p. 573 64. Chapter 44. The Impact of Gastrointestinal Modifications, Blood-Brain Barrier Transport, and Intracellular Metabolism on Polyphenol Bioavailability: An Overview - p. 586 65. Section 5.2: Polyphenolic Regulation of Metabolism - p. 599 66. Chapter 45. Polyphenols from Pongamia pinnata (Linn.) Pierre in Metabolic Disorder - p. 599 67. Chapter 46. Garlic (Allium sativum): Role in Metabolic Disorder - p. 610 68. Chapter 47. Polyphenols and Flavonoids in Controlling Non-Alcoholic Steatohepatitis - p. 614 69. Chapter 48. Modulation of Intestinal Cholesterol Absorption by Dietary Tea Polyphenols - p. 621 70. Section 6: Diverse Disease and Physiological States Modified by Polyphenols - p. 636 71. Section 6.1: Polyphenols in Clinical Medicine - p. 636 72. Chapter 49. Polyphenols and Skin Cancers - p. 636 73. Chapter 50. Polyphenols in the Prevention of Ulcerative Colitis: Past, Present and Future - p. 651 74. Chapter 51. Protection and Reversal of Hepatic Fibrosis by Polyphenols - p. 662 75. Chapter 52. Green Tea and other Fruit Polyphenols Attenuate Deterioration of Bone Microarchitecture - p. 676 76. Chapter 53. Polyphenolics Evoke Healing Responses: Clinical Evidence and Role of Predictive Biomarkers - p. 690 77. Chapter 54. Polyphenols and Reproductive Health - p. 704 78. Chapter 55. Hepatoprotective Effects of Green Tea and its Polyphenols: Preclinical Observations - p. 712 79. Chapter 56. Polyphenols and Tuberculosis - p. 720 80. Chapter 57. Protection by Polyphenols Against Mitochondrial Damage and Cytotoxicity - p. 729 81. Chapter 58. Safety of High and Long-term Intake of Polyphenols - p. 743 82. Chapter 59. Polyphenols in Health and Disease: Practice and Mechanisms of Benefits - p. 754 83. Chapter 60. Curcumin/Turmeric as an Environment-friendly Stain for Proteins on Acrylamide Gels - p. 774 84. Chapter 61. Turmeric and its Principle Compound Curcumin are Effective in the Prevention and Treatment of Arthritis - p. 783 85. Section 6.2: Polyphenols and Skin - p. 788 86. Chapter 62. Polyphenols and Polyphenol-Derived Compounds and Contact Dermatitis - p. 788 87. Chapter 63. Polyphenols against Skin Aging - p. 815 88. Chapter 64. Skin Photoprotection by Polyphenols in Animal Models and Humans - p. 827 89. Chapter 65. Polyphenols Nano-Formulations for Topical Delivery and Skin Tissue Engineering - p. 835 90. Chapter 66. Studying Tea Polyphenols and Their Protective Effects on Skin - p. 844 91. Chapter 67. Polyphenols: A Remedy for Skin Wrinkles - p. 858 92. Volume 2: Polyphenols in the Prevention and Treatment of Vascular and Cardiac Disease, and Cancer - p. 867 93. Section 7: Polyphenols and Vascular Health - p. 867 94. Section 7.1: Vascular Endothelial Protection of Polyphenols - p. 867 95. Chapter 68. Vascular Protective Effects of Fruit Polyphenols - p. 867 96. Chapter 69. Atherosclerosis and Mediterranean Diet Polyphenols - p. 889 97. Chapter 70. Polyphenol Modulation of Blood Flow and Oxygenation - p. 901 98. Chapter 71. Flax Lignan in the Prevention of Atherosclerotic Cardiovascular Diseases - p. 911 99. Chapter 72. Anthocyanins in Vascular Diseases - p. 920 100. Section 8: Cardiac Health and Polyphenols - p. 937 101. Section 8.1: Polyphenolic Cardiac Modification - p. 937 102. Chapter 73. Pharmacology of Polyphenols in Cardiac Remodeling: Potential Biological Mechanisms - p. 937 103. Chapter 74. Cacao Polyphenols Influence the Regulation of Apolipoproteins - p. 958 104. Chapter 75. Polyphenol Consumption and Blood Pressure - p. 968 105. Chapter 76. Cardiovascular Effects of Hesperidin: A Flavanone Glycoside - p. 983 106. Chapter 77. Wine Polyphenols in the Management of Cardiovascular Risk Factors - p. 992 107. Section 8.2: Polyphenol in Treatment and Prevention of Cardiac Disease - p. 1003 108. Chapter 78. Cocoa, Flavonoids and Cardiovascular Protection - p. 1003 109. Chapter 79. Emerging Applications of Metabolomics to Polyphenols and CVD Biomarker Discovery - p. 1020 110. Chapter 80. Role of Gallic Acid in Cardiovascular Disorders - p. 1039 111. Chapter 81. Cranberry Polyphenols: Effects on Cardiovascular Risk Factors - p. 1047 112. Chapter 82. Polyphenols and Cardiometabolic Syndrome - p. 1061 113. Chapter 83. Cocoa Polyphenols and Cardiovascular Health - p. 1075 114. Chapter 84. The Use of Bergamot-Derived Polyphenol Fraction in Cardiometabolic Risk Prevention and its Possible Mechanisms of Action - p. 1082 115. Chapter 85. Fruit Polyphenols and Postprandial Inflammatory Stress - p. 1103 116. Chapter 86. Modulation of Drug-Metabolizing Enzymes and Transporters by Polyphenols as an Anticarcinogenic Effect - p. 1122 117. Section 9: Cancer Prevention and Treatment of Polyphenols - p. 1134 118. Section 9.1: Mechanisms of Polyphenol Modulation of Cancer - p. 1134 119. Chapter 87. Polyphenol-Mediated In Vivo Cellular Responses during Carcinogenesis - p. 1134 120. Chapter 88. Preventive Effects of Plant Polyphenols in the Promotion of Mammary Cancer and Testicular Damage Induced by Alcohol Drinking - p. 1173 121. Chapter 89. Antioxidant and Pro-Oxidant Activities of Green Tea Polyphenols in Cancer Prevention - p. 1188 122. Chapter 90. Cancer Chemoprevention by Dietary Polyphenols: Role for Epigenetics and Inflammation - p. 1195 123. Chapter 91. Polyphenols in Prostate Cancer - p. 1211 124. Chapter 92. Modifying Effects of Polyphenols on Acute Colitis and Inflammation-Associated Colon Carcinogenesis - p. 1227 125. Chapter 93. Bioavailability of Soy-Derived Isoflavones and Human Breast Cancer - p. 1238 126. Chapter 94. Biological Activity of Resveratrol on an Ovarian Cancer Cell - p. 1251 127. Chapter 95. Resveratrol Inhibitory Effects against a Malignant Tumor: A Molecular Introductory Review - p. 1265 128. Chapter 96. Inhibition of Iron Absorption by Polyphenols as an Anticancer Mechanism - p. 1279 129. Section 9.2: Cancer Prevention by Polyphenols - p. 1285 130. Chapter 97. Plant Polyphenols as Chemopreventive Agents - p. 1285 131. Chapter 98. Cancer Preventive Effects of Green Tea Polyphenols - p. 1302 132. Chapter 99. Cancer Chemoprevention by Resveratrol Treatment - p. 1318 133. Chapter 100. Polyphenols and Breast Cancer Prevention: A Summary of the Epidemiologic Evidence - p. 1328 134. Chapter 101. Most Relevant Polyphenols Present in the Mediterranean Diet and Their Incidence in Cancer Diseases - p. 1338 135. Chapter 102. BRAF Mutation in Melanoma and Dietary Polyphenols as Adjunctive Treatment Strategy - p. 1348 136. Chapter 103. Radioprotective Effects of the Ocimum Flavonoids Orientin and Vicenin: Observations from Preclinical Studies - p. 1364 137. Chapter 104. Apple Polyphenols in Cancer Prevention - p. 1370 138. Chapter 105. DNA Methylation as a Target of Cancer Chemoprevention by Dietary Polyphenols - p. 1381 139. Chapter 106. Punica granatum (Pomegranate Fruit): In Cancer Treatment - p. 1390 140. Index - p. 1398
Polyphenols in Human Health and Disease documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more.
1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. About the Editors - p. IV 6. List of Contributors - p. XXI 7. Preface - p. XXI 8. Acknowledgments - p. XXXII 9. Volume 1: Polyphenols in Chronic Diseases and their Mechanisms of Action - p. XXXIII 10. Section 1: Overview of Polyphenols and Health - p. XXXIII 11. Chapter 1. Polyphenols in Foods and Dietary Supplements: Role in Veterinary Medicine and Animal Health - p. XXXIII 12. Chapter 2. Polyphenols and Public Health - p. 7 13. Chapter 3. The History of Islamic Medicine at a Glance - p. 14 14. Chapter 4. Polyphenols and Their Formulations: Different Strategies to Overcome the Drawbacks Associated with Their Poor Stability and Bioavailability - p. 26 15. Chapter 5. Biological Activities of Polyphenols from Grapes - p. 43 16. Chapter 6. The Atomic Level Interaction of Polyphenols with the Aβ Oligomer Aggregate, A Molecular Dynamic Guidance for Rational Drug Design - p. 53 17. Chapter 7. Polyphenols as Supplements in Foods and Beverages: Recent Methods, Benefits and Risks - p. 67 18. Section 2: Polyphenols in Therapy of Obesity and Diabetes - p. 76 19. Section 2.1: Polyphenols and Diabetes - p. 76 20. Chapter 8. Anthocyanins and Diabetes Regulation - p. 76 21. Chapter 9. Influence of Dietary Polyphenols on Carbohydrate Metabolism - p. 90 22. Chapter 10. Polyphenols in Ayurvedic Medicine and Type 2 Diabetes - p. 105 23. Chapter 11. Antidiabetic and Anticancer Potential of Native Medicinal Plants from Saudi Arabia - p. 117 24. Section 2.2: Polyphenols and Obesity - p. 130 25. Chapter 12. Prevention of Diet-Induced Obesity by Dietary Polyphenols Derived from Nelumbo nucifera and Black Tea - p. 130 26. Chapter 13. Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids - p. 141 27. Chapter 14. Dietary Quercetin and other Polyphenols: Attenuation of Obesity - p. 156 28. Chapter 15. Role of Protocatechuic Acid in Obesity-Related Pathologies - p. 172 29. Chapter 16. Food and Supplement Polyphenol Action in Cancer Recurrence - p. 184 30. Section 3: Oxidation and Antioxidant Activity of Polyphenols - p. 194 31. Section 3.1: Polyphenolic Antioxidants in Health Promotion - p. 194 32. Chapter 17. Implications of Polyphenols on Endogenous Antioxidant Defense Systems in Human Diseases - p. 194 33. Chapter 18. Potent Antioxidant and Anti-Inflammatory Flavonoids in the Nutrient-Rich Amazonian Palm Fruit, Açaí (Euterpe spp.) - p. 211 34. Chapter 19. Dark Chocolate/Cocoa Polyphenols and Oxidative Stress - p. 236 35. Chapter 20. Polyphenol Antioxidants from Natural Sources and Contribution to Health Promotion - p. 249 36. Chapter 21. Antioxidant Role of Catechin in Health and Disease - p. 263 37. Section 3.2: Mechanisms of Polyphenols’ Antioxidant Effects - p. 270 38. Chapter 22. Cytoprotective Effects of Polyphenols against Oxidative Damage - p. 270 39. Chapter 23. The Role of Direct and Indirect Polyphenolic Antioxidants in Protection Against Oxidative Stress - p. 285 40. Chapter 24. Polyphenols and Low Iron Bioavailability - p. 304 41. Chapter 25. Galloylation and Polymerization: Role of Structure to Antioxidant Activity of Polyphenols in Lipid Systems - p. 319 42. Chapter 26. Chemical Properties, Bioavailability, and Metabolomics of Fruit Proanthocyanidins - p. 336 43. Section 4: Polyphenols in Brain and Neurobiology Health - p. 348 44. Section 4.1: Mechanisms of Polyphenols in Neurobiology - p. 348 45. Chapter 27. Plant Polyphenols as Dietary Modulators of Brain Functions - p. 348 46. Section 5: Inflammation and Polyphenols - p. 365 47. Chapter 28. Anti-Inflammatory Activity of Polyphenols on Dendritic Cells - p. 365 48. Chapter 29. Polyphenols Suppress and Modulate Inflammation: Possible Roles in Health and Disease - p. 389 49. Chapter 30. Anti-Inflammatory Properties of Cinnamon Polyphenols and their Monomeric Precursors - p. 402 50. Chapter 31. Polyphenols in the Prevention of Acute Pancreatitis: Preclinical Observations - p. 421 51. Chapter 32. Anti-Inflammatory and Immunomodulatory Properties of Dietary Flavonoids - p. 432 52. Chapter 33. Immunomodulatory Ethnobotanicals of the Great Lakes - p. 446 53. Chapter 34. Pongamia pinnata (Linn.) Pierre and Inflammation - p. 459 54. Chapter 35. Polyphenol-Mediated Beneficial Effects in Healthy Status and Disease with Special Reference to Immune-Based Mechanisms - p. 465 55. Section 5.1: Bioavailability and Effects on Metabolism - p. 475 56. Chapter 36. Using Recombinant Microorganisms for the Synthesis and Modification of Flavonoids and Stilbenes - p. 475 57. Chapter 37. Bioavailability of Flavonoids: The Role of Cell Membrane Transporters - p. 487 58. Chapter 38. Microorganism Metabolic Activity Stimulation by Polyphenols - p. 504 59. Chapter 39. Interaction of Polyphenols with the Intestinal and Placental Absorption of some Nutrients and other Compounds - p. 520 60. Chapter 40. Bioavailability and Metabolism of Citrus Fruit Beverage Flavanones in Humans - p. 532 61. Chapter 41. Uptake and Metabolism of Dietary Proanthocyanidins - p. 547 62. Chapter 42. Bioavailability of Dietary Anthocyanins and Hydroxycinnamic Acids - p. 558 63. Chapter 43. Microbial Metabolism of Polyphenols and Health - p. 573 64. Chapter 44. The Impact of Gastrointestinal Modifications, Blood-Brain Barrier Transport, and Intracellular Metabolism on Polyphenol Bioavailability: An Overview - p. 586 65. Section 5.2: Polyphenolic Regulation of Metabolism - p. 599 66. Chapter 45. Polyphenols from Pongamia pinnata (Linn.) Pierre in Metabolic Disorder - p. 599 67. Chapter 46. Garlic (Allium sativum): Role in Metabolic Disorder - p. 610 68. Chapter 47. Polyphenols and Flavonoids in Controlling Non-Alcoholic Steatohepatitis - p. 614 69. Chapter 48. Modulation of Intestinal Cholesterol Absorption by Dietary Tea Polyphenols - p. 621 70. Section 6: Diverse Disease and Physiological States Modified by Polyphenols - p. 636 71. Section 6.1: Polyphenols in Clinical Medicine - p. 636 72. Chapter 49. Polyphenols and Skin Cancers - p. 636 73. Chapter 50. Polyphenols in the Prevention of Ulcerative Colitis: Past, Present and Future - p. 651 74. Chapter 51. Protection and Reversal of Hepatic Fibrosis by Polyphenols - p. 662 75. Chapter 52. Green Tea and other Fruit Polyphenols Attenuate Deterioration of Bone Microarchitecture - p. 676 76. Chapter 53. Polyphenolics Evoke Healing Responses: Clinical Evidence and Role of Predictive Biomarkers - p. 690 77. Chapter 54. Polyphenols and Reproductive Health - p. 704 78. Chapter 55. Hepatoprotective Effects of Green Tea and its Polyphenols: Preclinical Observations - p. 712 79. Chapter 56. Polyphenols and Tuberculosis - p. 720 80. Chapter 57. Protection by Polyphenols Against Mitochondrial Damage and Cytotoxicity - p. 729 81. Chapter 58. Safety of High and Long-term Intake of Polyphenols - p. 743 82. Chapter 59. Polyphenols in Health and Disease: Practice and Mechanisms of Benefits - p. 754 83. Chapter 60. Curcumin/Turmeric as an Environment-friendly Stain for Proteins on Acrylamide Gels - p. 774 84. Chapter 61. Turmeric and its Principle Compound Curcumin are Effective in the Prevention and Treatment of Arthritis - p. 783 85. Section 6.2: Polyphenols and Skin - p. 788 86. Chapter 62. Polyphenols and Polyphenol-Derived Compounds and Contact Dermatitis - p. 788 87. Chapter 63. Polyphenols against Skin Aging - p. 815 88. Chapter 64. Skin Photoprotection by Polyphenols in Animal Models and Humans - p. 827 89. Chapter 65. Polyphenols Nano-Formulations for Topical Delivery and Skin Tissue Engineering - p. 835 90. Chapter 66. Studying Tea Polyphenols and Their Protective Effects on Skin - p. 844 91. Chapter 67. Polyphenols: A Remedy for Skin Wrinkles - p. 858 92. Volume 2: Polyphenols in the Prevention and Treatment of Vascular and Cardiac Disease, and Cancer - p. 867 93. Section 7: Polyphenols and Vascular Health - p. 867 94. Section 7.1: Vascular Endothelial Protection of Polyphenols - p. 867 95. Chapter 68. Vascular Protective Effects of Fruit Polyphenols - p. 867 96. Chapter 69. Atherosclerosis and Mediterranean Diet Polyphenols - p. 889 97. Chapter 70. Polyphenol Modulation of Blood Flow and Oxygenation - p. 901 98. Chapter 71. Flax Lignan in the Prevention of Atherosclerotic Cardiovascular Diseases - p. 911 99. Chapter 72. Anthocyanins in Vascular Diseases - p. 920 100. Section 8: Cardiac Health and Polyphenols - p. 937 101. Section 8.1: Polyphenolic Cardiac Modification - p. 937 102. Chapter 73. Pharmacology of Polyphenols in Cardiac Remodeling: Potential Biological Mechanisms - p. 937 103. Chapter 74. Cacao Polyphenols Influence the Regulation of Apolipoproteins - p. 958 104. Chapter 75. Polyphenol Consumption and Blood Pressure - p. 968 105. Chapter 76. Cardiovascular Effects of Hesperidin: A Flavanone Glycoside - p. 983 106. Chapter 77. Wine Polyphenols in the Management of Cardiovascular Risk Factors - p. 992 107. Section 8.2: Polyphenol in Treatment and Prevention of Cardiac Disease - p. 1003 108. Chapter 78. Cocoa, Flavonoids and Cardiovascular Protection - p. 1003 109. Chapter 79. Emerging Applications of Metabolomics to Polyphenols and CVD Biomarker Discovery - p. 1020 110. Chapter 80. Role of Gallic Acid in Cardiovascular Disorders - p. 1039 111. Chapter 81. Cranberry Polyphenols: Effects on Cardiovascular Risk Factors - p. 1047 112. Chapter 82. Polyphenols and Cardiometabolic Syndrome - p. 1061 113. Chapter 83. Cocoa Polyphenols and Cardiovascular Health - p. 1075 114. Chapter 84. The Use of Bergamot-Derived Polyphenol Fraction in Cardiometabolic Risk Prevention and its Possible Mechanisms of Action - p. 1082 115. Chapter 85. Fruit Polyphenols and Postprandial Inflammatory Stress - p. 1103 116. Chapter 86. Modulation of Drug-Metabolizing Enzymes and Transporters by Polyphenols as an Anticarcinogenic Effect - p. 1122 117. Section 9: Cancer Prevention and Treatment of Polyphenols - p. 1134 118. Section 9.1: Mechanisms of Polyphenol Modulation of Cancer - p. 1134 119. Chapter 87. Polyphenol-Mediated In Vivo Cellular Responses during Carcinogenesis - p. 1134 120. Chapter 88. Preventive Effects of Plant Polyphenols in the Promotion of Mammary Cancer and Testicular Damage Induced by Alcohol Drinking - p. 1173 121. Chapter 89. Antioxidant and Pro-Oxidant Activities of Green Tea Polyphenols in Cancer Prevention - p. 1188 122. Chapter 90. Cancer Chemoprevention by Dietary Polyphenols: Role for Epigenetics and Inflammation - p. 1195 123. Chapter 91. Polyphenols in Prostate Cancer - p. 1211 124. Chapter 92. Modifying Effects of Polyphenols on Acute Colitis and Inflammation-Associated Colon Carcinogenesis - p. 1227 125. Chapter 93. Bioavailability of Soy-Derived Isoflavones and Human Breast Cancer - p. 1238 126. Chapter 94. Biological Activity of Resveratrol on an Ovarian Cancer Cell - p. 1251 127. Chapter 95. Resveratrol Inhibitory Effects against a Malignant Tumor: A Molecular Introductory Review - p. 1265 128. Chapter 96. Inhibition of Iron Absorption by Polyphenols as an Anticancer Mechanism - p. 1279 129. Section 9.2: Cancer Prevention by Polyphenols - p. 1285 130. Chapter 97. Plant Polyphenols as Chemopreventive Agents - p. 1285 131. Chapter 98. Cancer Preventive Effects of Green Tea Polyphenols - p. 1302 132. Chapter 99. Cancer Chemoprevention by Resveratrol Treatment - p. 1318 133. Chapter 100. Polyphenols and Breast Cancer Prevention: A Summary of the Epidemiologic Evidence - p. 1328 134. Chapter 101. Most Relevant Polyphenols Present in the Mediterranean Diet and Their Incidence in Cancer Diseases - p. 1338 135. Chapter 102. BRAF Mutation in Melanoma and Dietary Polyphenols as Adjunctive Treatment Strategy - p. 1348 136. Chapter 103. Radioprotective Effects of the Ocimum Flavonoids Orientin and Vicenin: Observations from Preclinical Studies - p. 1364 137. Chapter 104. Apple Polyphenols in Cancer Prevention - p. 1370 138. Chapter 105. DNA Methylation as a Target of Cancer Chemoprevention by Dietary Polyphenols - p. 1381 139. Chapter 106. Punica granatum (Pomegranate Fruit): In Cancer Treatment - p. 1390 140. Index - p. 1398
