Preclinical Research in Down Syndrome: From Bench to Bedside, Volume 251, the latest release in the Progress in Brain Research series, highlights new advances in the field. Chapters in this updated release include Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Dow syndrome, The trisomy paradox: gene expression dysregulation domains, the Influence of allelic differences in mouse models of Down syndrome, Modelling Down syndrome in cells: From stem cells to organoids, Modelling Down syndrome in animals from the early stage to the new generation of models, Mapping behavioral landscapes in Down syndrome animal models, and more.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_v 6. Preface - p. page_xv 7. Chapter 1: Genetic and epigenetic pathways in Down syndrome: Insights to the brain and immune system from humans and mouse models - p. page_xv 8. Chapter 2: Influence of allelic differences in Down syndrome - p. page_28 9. Chapter 3: Modeling Down syndrome in cells: From stem cells to organoids - p. page_54 10. Chapter 4: Modeling Down syndrome in animals from the early stage to the 4.0 models and next - p. page_90 11. Chapter 5: Mapping behavioral landscapes in Down syndrome animal models - p. page_143 12. Chapter 6: Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of chromosome 21 - p. page_179 13. Chapter 7: Focusing on cellular biomarkers: The endo-lysosomal pathway in Down syndrome - p. page_208 14. Chapter 8: Translational validity and implications of pharmacotherapies in preclinical models of Down syndrome - p. page_243 15. Chapter 9: Plasticity as a therapeutic target for improving cognition and behavior in Down syndrome - p. page_268
Preclinical Research in Down Syndrome: From Bench to Bedside, Volume 251, the latest release in the Progress in Brain Research series, highlights new advances in the field. Chapters in this updated release include Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Dow syndrome, The trisomy paradox: gene expression dysregulation domains, the Influence of allelic differences in mouse models of Down syndrome, Modelling Down syndrome in cells: From stem cells to organoids, Modelling Down syndrome in animals from the early stage to the new generation of models, Mapping behavioral landscapes in Down syndrome animal models, and more.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_v 6. Preface - p. page_xv 7. Chapter 1: Genetic and epigenetic pathways in Down syndrome: Insights to the brain and immune system from humans and mouse models - p. page_xv 8. Chapter 2: Influence of allelic differences in Down syndrome - p. page_28 9. Chapter 3: Modeling Down syndrome in cells: From stem cells to organoids - p. page_54 10. Chapter 4: Modeling Down syndrome in animals from the early stage to the 4.0 models and next - p. page_90 11. Chapter 5: Mapping behavioral landscapes in Down syndrome animal models - p. page_143 12. Chapter 6: Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of chromosome 21 - p. page_179 13. Chapter 7: Focusing on cellular biomarkers: The endo-lysosomal pathway in Down syndrome - p. page_208 14. Chapter 8: Translational validity and implications of pharmacotherapies in preclinical models of Down syndrome - p. page_243 15. Chapter 9: Plasticity as a therapeutic target for improving cognition and behavior in Down syndrome - p. page_268
