Comprehensive in scope, yet concise and easy to manage, Principles and Practice of Pediatric Infectious Diseases, 6th Edition, by Drs. Sarah S. Long, Charles G. Prober, Marc Fischer, and new editor David Kimberlin, is your go-to resource for authoritative information on infectious diseases in children and adolescents. A veritable "who's who" of global authorities provides the practical knowledge you need to understand, diagnose, and manage almost any pediatric infectious disease you may encounter.
Covers the latest aspects of the COVID-19 pandemic, including manifestations, diagnosis, management, and prevention of SARS-CoV-2 infection.
Features an easy-access format with high-yield information boxes, highlighted key points, and an abundance of detailed illustrations and at-a-glance tables.
Allows quick look-up by clinical presentation, pathogen, or type of host.
Highlights expanding antimicrobial resistance patterns and new therapies for viral and fungal infections and resistant bacterial infections.
Includes coverage of the latest vaccine products, recommendations, and effectiveness.
Reviews emerging healthcare-associated infections, their management, control, and prevention.
Contains a new chapter on Chorioamnionitis and Neonatal Consequences.
1. 203. Introduction to Herpesviridae - p. 1074 2. 204. Herpes Simplex Virus - p. 1075 3. 205. Varicella-Zoster Virus - p. 1084 4. 206. Cytomegalovirus - p. 1092 5. 207. Human Herpesviruses 6 and 7 (Roseola, Exanthem Subitum) - p. 1099 6. 208. Epstein-Barr Virus (Mononucleosis and Lymphoproliferative Disorders) - p. 1107 7. 209. Human Herpesvirus 8 (Kaposi Sarcoma–Associated Herpesvirus) - p. 1113 8. DNA Viruses: Adenoviridae - p. 1115.e1 9. 210. Adenoviruses - p. 1115 10. DNA Viruses: Papovaviridae - p. 1119.e3 11. 211. Human Papillomavirus - p. 1119 12. 212. BK, JC, and Other Human Polyomaviruses - p. 1123 13. DNA Viruses: Hepadnaviridae - p. 1125.e3 14. 213. Hepatitis B and Hepatitis D Viruses - p. 1125 15. DNA Viruses: Parvoviridae - p. 1133.e4 16. 214. Human Parvoviruses (Parvovirus B19 and Bocavirus) - p. 1133 17. RNA Viruses: Reoviridae - p. 1138.e2 18. 215. Coltivirus (Colorado Tick Fever) - p. 1138 19. 216. Rotaviruses - p. 1141 20. RNA Viruses: Togaviridae, Flaviviridae, and Bunyaviridae - p. 1144.e3 21. 217. Togaviridae: Alphaviruses - p. 1145 22. 218. Flaviviruses - p. 1147 23. 219. Bunyaviruses - p. 1152 24. 220. Hepatitis C Virus - p. 1156 25. 221. Rubella Virus - p. 1161 26. RNA Viruses: Coronaviridae - p. 1167.e2 27. 222. Human Coronaviruses - p. 1167 28. RNA Viruses: Paramyxoviridae - p. 1175.e6 29. 223. Parainfluenza Viruses - p. 1175 30. 224. Mumps Virus - p. 1180 31. 225. Respiratory Syncytial Virus - p. 1185 32. 226. Human Metapneumovirus - p. 1189 33. 227. Rubeola Virus: Measles and Subacute Sclerosing Panencephalitis - p. 1192 34. RNA Viruses: Rhabdoviridae - p. 1201.e3 35. 228. Rabies Virus - p. 1201 36. RNA Viruses: Orthomyxoviridae - p. 1204.e1 37. 229. Influenza Viruses - p. 1205 38. RNA Viruses: Arenaviridae and Filoviridae - p. 1213.e5 39. 230. Filoviruses and Arenaviruses - p. 1213 40. RNA Viruses: Retroviridae - p. 1219.e2 41. 231. Introduction to Retroviridae - p. 1219.e2 42. 232. Human T-Cell Lymphotropic Viruses - p. 1220 43. 233. Human Immunodeficiency Virus - p. 1222 44. RNA Viruses: Picornaviridae - p. 1223 45. 234. Introduction to Picornaviridae - p. 1224 46. 235. Polioviruses - p. 1225 47. 236. Enteroviruses and Parechoviruses - p. 1228 48. 237. Hepatitis A Virus - p. 1237 49. 238. Rhinoviruses - p. 1243 50. RNA Viruses: Caliciviridae - p. 1245.e1 51. 239. Caliciviruses - p. 1245 52. 240. Astroviruses - p. 1248 53. 241. Hepatitis E Virus - p. 1250 54. Section C. Fungi - p. 1252.e2 55. 242. Classification of Fungi - p. 1253 56. 243. Candida Species - p. 1255 57. 244. Aspergillus Species - p. 1262 58. 245. Agents of Hyalohyphomycosis and Phaeohyphomycosis - p. 1269 59. 246. Agents of Mucormycosis - p. 1272 60. 247. Malassezia Species - p. 1274 61. 248. Sporothrix schenckii Complex (Sporotrichosis) - p. 1277 62. 249. Cryptococcus Species - p. 1279 63. 250. Histoplasma capsulatum (Histoplasmosis) - p. 1283 64. 251. Pneumocystis jirovecii - p. 1290 65. 252. Blastomyces Species (Blastomycosis) - p. 1294 66. 253. Coccidioides immitis and Coccidioides posadasii (Coccidioidomycosis) - p. 1301 67. 254. Superficial Fungal Infections - p. 1307 68. 255. Agents of Eumycotic Mycetoma: Pseudallescheria boydii and Scedosporium apiospermum - p. 1317 69. Section D. Human Parasites and Vectors - p. 1321.e2 70. 256. Classification of Parasites - p. 1322 71. 257. Ectoparasites (Lice and Scabies) - p. 1324 72. Protozoa - p. 1328.e1 73. 258. Babesia Species (Babesiosis) - p. 1329 74. 259. Balantioides coli (Formerly Balantidium coli) - p. 1334 75. 260. Blastocystis Species - p. 1335 76. 261. Cryptosporidium Species - p. 1337 77. 262. Endolimax nana - p. 1339 78. 263. Entamoeba histolytica (Amebiasis) - p. 1341 79. 264. Other Entamoeba, Amebae, and Intestinal Flagellates - p. 1347 80. 265. Giardia intestinalis (Giardiasis) - p. 1348 81. 266. Cystoisospora (Isospora) and Cyclospora Species - p. 1353 82. 267. Leishmania Species (Leishmaniasis) - p. 1354 83. 268. Microsporidia - p. 1365 84. 269. Naegleria fowleri - p. 1366 85. 270. Acanthamoeba Species - p. 1369 86. 271. Plasmodium Species (Malaria) - p. 1372 87. 272. Sarcocystis Species - p. 1382 88. 273. Toxoplasma gondii (Toxoplasmosis) - p. 1384 89. 274. Trichomonas vaginalis - p. 1400 90. 275. Trypanosoma Species (Trypanosomiasis) - p. 1402 91. Nematodes - p. 1409.e3 92. 276. Intestinal Nematodes - p. 1409 93. 277. Tissue Nematodes - p. 1418 94. 278. Blood and Tissue Nematodes: Filarial Worms - p. 1424 95. Cestodes - p. 1431.e1 96. 279. Diphyllobothriidae, Dipylidium and Hymenolepis Species - p. 1431 97. 280. Taenia solium, Taenia asiatica, and Taenia saginata: Taeniasis and Cysticercosis - p. 1435 98. 281. Echinococcus Species: Agents of Echinococcosis - p. 1442 99. 282. Taenia (Multiceps) multiceps and Taenia serialis: Coenurosis - p. 1448 100. Trematodes - p. 1449.e1 101. 283. Intestinal Trematodes - p. 1449 102. 284. Clonorchis, Opisthorchis, Fasciola, and Paragonimus Species - p. 1451 103. 285. Blood Trematodes: Schistosomiasis - p. 1456 104. Laboratory Diagnosis and Therapy for Infectious Diseases - p. 1458.e1 105. Section A. The Clinician and the Laboratory - p. 1458.e1 106. 286. Laboratory Diagnosis of Infection Due to Bacteria, Fungi, Parasites, and Rickettsiae - p. 1459 107. 287. Laboratory Diagnosis of Infection Due to Viruses,Chlamydia, and Mycoplasma - p. 1472 108. 288. Use of Common Clinical Laboratory Tests to Assess Infectious and Inflammatory Diseases - p. 1484 109. Section B. Anti-Infective Therapy - p. 1498.e5 110. 289. Principles of Anti-Infective Therapy - p. 1499 111. 290. Mechanisms and Detection of Antimicrobial Resistance - p. 1506 112. 291. Pharmacokinetic and Pharmacodynamic Basis of Optimal Antimicrobial Therapy - p. 1516.e4 113. Basic Concepts in Clinical Pharmacokinetics - p. 1516.e4 114. Drug Disposition in Specific Patient Populations - p. 1518 115. Basis for Drug-Drug Interactions - p. 1520 116. Pharmacodynamic Interactions - p. 1523 117. Integration of Pharmacokinetic and Pharmacodynamic Principles for Optimal Antibiotic Dosing Regimens - p. 1524 118. Pharmacokinetic and Pharmacodynamic Relationships of Other Antimicrobial Agents - p. 1526 119. Future Considerations - p. 1526 120. 292. Antibacterial Agents - p. 1537.e7 121. Cell Envelope-Active Agents - p. 1537.e7 122. Cell Wall-Active Agents - p. 1537.e7 123. Cell Membrane-Active Agents - p. 1551 124. Salivaricins - p. 1552 125. Ribosome-Active Antibiotics - p. 1552 126. Nucleic Acid-Active Antibiotics - p. 1557 127. 293. Antifungal Agents - p. 1564 128. 294. Topical Antimicrobial Agents - p. 1573 129. 295. Antiviral Agents - p. 1583 130. Anti-Herpesvirus Drugs - p. 1583 131. Anti-Influenza Drugs - p. 1592 132. Anti-Hepatitis Virus Drugs - p. 1594 133. Anti-Coronavirus Drugs - p. 1597 134. 296. Antiparasitic Agents - p. 1598 135. Index - p. 1619
Comprehensive in scope, yet concise and easy to manage, Principles and Practice of Pediatric Infectious Diseases, 6th Edition, by Drs. Sarah S. Long, Charles G. Prober, Marc Fischer, and new editor David Kimberlin, is your go-to resource for authoritative information on infectious diseases in children and adolescents. A veritable "who's who" of global authorities provides the practical knowledge you need to understand, diagnose, and manage almost any pediatric infectious disease you may encounter.
Covers the latest aspects of the COVID-19 pandemic, including manifestations, diagnosis, management, and prevention of SARS-CoV-2 infection.
Features an easy-access format with high-yield information boxes, highlighted key points, and an abundance of detailed illustrations and at-a-glance tables.
Allows quick look-up by clinical presentation, pathogen, or type of host.
Highlights expanding antimicrobial resistance patterns and new therapies for viral and fungal infections and resistant bacterial infections.
Includes coverage of the latest vaccine products, recommendations, and effectiveness.
Reviews emerging healthcare-associated infections, their management, control, and prevention.
Contains a new chapter on Chorioamnionitis and Neonatal Consequences.
1. 203. Introduction to Herpesviridae - p. 1074 2. 204. Herpes Simplex Virus - p. 1075 3. 205. Varicella-Zoster Virus - p. 1084 4. 206. Cytomegalovirus - p. 1092 5. 207. Human Herpesviruses 6 and 7 (Roseola, Exanthem Subitum) - p. 1099 6. 208. Epstein-Barr Virus (Mononucleosis and Lymphoproliferative Disorders) - p. 1107 7. 209. Human Herpesvirus 8 (Kaposi Sarcoma–Associated Herpesvirus) - p. 1113 8. DNA Viruses: Adenoviridae - p. 1115.e1 9. 210. Adenoviruses - p. 1115 10. DNA Viruses: Papovaviridae - p. 1119.e3 11. 211. Human Papillomavirus - p. 1119 12. 212. BK, JC, and Other Human Polyomaviruses - p. 1123 13. DNA Viruses: Hepadnaviridae - p. 1125.e3 14. 213. Hepatitis B and Hepatitis D Viruses - p. 1125 15. DNA Viruses: Parvoviridae - p. 1133.e4 16. 214. Human Parvoviruses (Parvovirus B19 and Bocavirus) - p. 1133 17. RNA Viruses: Reoviridae - p. 1138.e2 18. 215. Coltivirus (Colorado Tick Fever) - p. 1138 19. 216. Rotaviruses - p. 1141 20. RNA Viruses: Togaviridae, Flaviviridae, and Bunyaviridae - p. 1144.e3 21. 217. Togaviridae: Alphaviruses - p. 1145 22. 218. Flaviviruses - p. 1147 23. 219. Bunyaviruses - p. 1152 24. 220. Hepatitis C Virus - p. 1156 25. 221. Rubella Virus - p. 1161 26. RNA Viruses: Coronaviridae - p. 1167.e2 27. 222. Human Coronaviruses - p. 1167 28. RNA Viruses: Paramyxoviridae - p. 1175.e6 29. 223. Parainfluenza Viruses - p. 1175 30. 224. Mumps Virus - p. 1180 31. 225. Respiratory Syncytial Virus - p. 1185 32. 226. Human Metapneumovirus - p. 1189 33. 227. Rubeola Virus: Measles and Subacute Sclerosing Panencephalitis - p. 1192 34. RNA Viruses: Rhabdoviridae - p. 1201.e3 35. 228. Rabies Virus - p. 1201 36. RNA Viruses: Orthomyxoviridae - p. 1204.e1 37. 229. Influenza Viruses - p. 1205 38. RNA Viruses: Arenaviridae and Filoviridae - p. 1213.e5 39. 230. Filoviruses and Arenaviruses - p. 1213 40. RNA Viruses: Retroviridae - p. 1219.e2 41. 231. Introduction to Retroviridae - p. 1219.e2 42. 232. Human T-Cell Lymphotropic Viruses - p. 1220 43. 233. Human Immunodeficiency Virus - p. 1222 44. RNA Viruses: Picornaviridae - p. 1223 45. 234. Introduction to Picornaviridae - p. 1224 46. 235. Polioviruses - p. 1225 47. 236. Enteroviruses and Parechoviruses - p. 1228 48. 237. Hepatitis A Virus - p. 1237 49. 238. Rhinoviruses - p. 1243 50. RNA Viruses: Caliciviridae - p. 1245.e1 51. 239. Caliciviruses - p. 1245 52. 240. Astroviruses - p. 1248 53. 241. Hepatitis E Virus - p. 1250 54. Section C. Fungi - p. 1252.e2 55. 242. Classification of Fungi - p. 1253 56. 243. Candida Species - p. 1255 57. 244. Aspergillus Species - p. 1262 58. 245. Agents of Hyalohyphomycosis and Phaeohyphomycosis - p. 1269 59. 246. Agents of Mucormycosis - p. 1272 60. 247. Malassezia Species - p. 1274 61. 248. Sporothrix schenckii Complex (Sporotrichosis) - p. 1277 62. 249. Cryptococcus Species - p. 1279 63. 250. Histoplasma capsulatum (Histoplasmosis) - p. 1283 64. 251. Pneumocystis jirovecii - p. 1290 65. 252. Blastomyces Species (Blastomycosis) - p. 1294 66. 253. Coccidioides immitis and Coccidioides posadasii (Coccidioidomycosis) - p. 1301 67. 254. Superficial Fungal Infections - p. 1307 68. 255. Agents of Eumycotic Mycetoma: Pseudallescheria boydii and Scedosporium apiospermum - p. 1317 69. Section D. Human Parasites and Vectors - p. 1321.e2 70. 256. Classification of Parasites - p. 1322 71. 257. Ectoparasites (Lice and Scabies) - p. 1324 72. Protozoa - p. 1328.e1 73. 258. Babesia Species (Babesiosis) - p. 1329 74. 259. Balantioides coli (Formerly Balantidium coli) - p. 1334 75. 260. Blastocystis Species - p. 1335 76. 261. Cryptosporidium Species - p. 1337 77. 262. Endolimax nana - p. 1339 78. 263. Entamoeba histolytica (Amebiasis) - p. 1341 79. 264. Other Entamoeba, Amebae, and Intestinal Flagellates - p. 1347 80. 265. Giardia intestinalis (Giardiasis) - p. 1348 81. 266. Cystoisospora (Isospora) and Cyclospora Species - p. 1353 82. 267. Leishmania Species (Leishmaniasis) - p. 1354 83. 268. Microsporidia - p. 1365 84. 269. Naegleria fowleri - p. 1366 85. 270. Acanthamoeba Species - p. 1369 86. 271. Plasmodium Species (Malaria) - p. 1372 87. 272. Sarcocystis Species - p. 1382 88. 273. Toxoplasma gondii (Toxoplasmosis) - p. 1384 89. 274. Trichomonas vaginalis - p. 1400 90. 275. Trypanosoma Species (Trypanosomiasis) - p. 1402 91. Nematodes - p. 1409.e3 92. 276. Intestinal Nematodes - p. 1409 93. 277. Tissue Nematodes - p. 1418 94. 278. Blood and Tissue Nematodes: Filarial Worms - p. 1424 95. Cestodes - p. 1431.e1 96. 279. Diphyllobothriidae, Dipylidium and Hymenolepis Species - p. 1431 97. 280. Taenia solium, Taenia asiatica, and Taenia saginata: Taeniasis and Cysticercosis - p. 1435 98. 281. Echinococcus Species: Agents of Echinococcosis - p. 1442 99. 282. Taenia (Multiceps) multiceps and Taenia serialis: Coenurosis - p. 1448 100. Trematodes - p. 1449.e1 101. 283. Intestinal Trematodes - p. 1449 102. 284. Clonorchis, Opisthorchis, Fasciola, and Paragonimus Species - p. 1451 103. 285. Blood Trematodes: Schistosomiasis - p. 1456 104. Laboratory Diagnosis and Therapy for Infectious Diseases - p. 1458.e1 105. Section A. The Clinician and the Laboratory - p. 1458.e1 106. 286. Laboratory Diagnosis of Infection Due to Bacteria, Fungi, Parasites, and Rickettsiae - p. 1459 107. 287. Laboratory Diagnosis of Infection Due to Viruses,Chlamydia, and Mycoplasma - p. 1472 108. 288. Use of Common Clinical Laboratory Tests to Assess Infectious and Inflammatory Diseases - p. 1484 109. Section B. Anti-Infective Therapy - p. 1498.e5 110. 289. Principles of Anti-Infective Therapy - p. 1499 111. 290. Mechanisms and Detection of Antimicrobial Resistance - p. 1506 112. 291. Pharmacokinetic and Pharmacodynamic Basis of Optimal Antimicrobial Therapy - p. 1516.e4 113. Basic Concepts in Clinical Pharmacokinetics - p. 1516.e4 114. Drug Disposition in Specific Patient Populations - p. 1518 115. Basis for Drug-Drug Interactions - p. 1520 116. Pharmacodynamic Interactions - p. 1523 117. Integration of Pharmacokinetic and Pharmacodynamic Principles for Optimal Antibiotic Dosing Regimens - p. 1524 118. Pharmacokinetic and Pharmacodynamic Relationships of Other Antimicrobial Agents - p. 1526 119. Future Considerations - p. 1526 120. 292. Antibacterial Agents - p. 1537.e7 121. Cell Envelope-Active Agents - p. 1537.e7 122. Cell Wall-Active Agents - p. 1537.e7 123. Cell Membrane-Active Agents - p. 1551 124. Salivaricins - p. 1552 125. Ribosome-Active Antibiotics - p. 1552 126. Nucleic Acid-Active Antibiotics - p. 1557 127. 293. Antifungal Agents - p. 1564 128. 294. Topical Antimicrobial Agents - p. 1573 129. 295. Antiviral Agents - p. 1583 130. Anti-Herpesvirus Drugs - p. 1583 131. Anti-Influenza Drugs - p. 1592 132. Anti-Hepatitis Virus Drugs - p. 1594 133. Anti-Coronavirus Drugs - p. 1597 134. 296. Antiparasitic Agents - p. 1598 135. Index - p. 1619
