Protein-based Nanoparticles in Drug Delivery is a comprehensive book aimed at pharmaceutical scientists and researchers both in academia and corporate environments focused on nanotechnology drug delivery and pharmaceutical-related disciplines. The book covers the design and characterization of various protein nanoparticles, sheds light on the power of an endogenous substance as a drug delivery system, and highlights the possible future trends in the use of protein-based drug delivery. It covers in-depth novel applications of protein-based drug delivery from fundamental to most current use cases. The book comprises three parts. Part one is devoted to the foundations of protein-based drug delivery, including nanocarriers development, drug encapsulation, targetability, and in vivo properties. Part two explores the applications of protein-based nanoparticles in drug delivery, covering topics such as protein nanoparticles in cancer therapy, genetic material delivery, and nanocarriers based on milk protein, silk, and gliadin. Part three addresses recent advances and regulatory aspects of protein-based nanoparticles in drug delivery, including clinical translation, challenges, biological toxicity, and environmental hazards associated with protein-based nanoparticles. Protein-based Nanoparticles in Drug Delivery provides a complete journey of protein-based drug delivery, offers an in-depth understanding of the design and characterization of various protein nanoparticles, and highlights possible future trends in this field. Pharmaceutical scientists will benefit from the novel applications of protein-based nanoparticles drug delivery approaches in the biological field. Nanotechnologists, biologists, chemists, physicists, engineers, and clinicians will also benefit from the foundational content provided as a basis to support communication and tackle the multidisciplinary challenges associated with research in this exciting field.
1. Chapter 3. History, introduction, properties, and applications of protein-based drug delivery - p. 83 2. Chapter 4. Methods of preparation, characterization parameters, and pharmaceutical application for protein based nanoparticles - p. 113 3. Chapter 5. Design, development, and drug delivery applications of self-assembling nanocarriers from engineered proteins - p. 139 4. Chapter 6. Mechanism of protein-based nanoparticle interactions - p. 179 5. Part II. Applications of protein-based nanoparticles in drug delivery - p. P2 6. Chapter 7. Protein nanoparticles in cancer therapy - p. 211 7. 1 Introduction - p. 211 8. 2 Utilization of PNPs in cancer therapeutic modalities - p. 212 9. 3 Tumor-targeting strategies for PNP delivery - p. 217 10. 4 TME-responsive PNPs for cancer therapy - p. 218 11. 5 Protein nanoparticle platforms - p. 224 12. 6 Protein nanoparticles marketed and under clinical trial - p. 254 13. 7 Concluding remarks - p. 257 14. Chapter 8. Protein nanoparticles in cancer imaging - p. 273 15. Chapter 9. Protein-based nanotechnologies as cancer theranostics - p. 297 16. Chapter 10. Protein-based nanoparticles for the delivery of genetic materials - p. 327 17. Chapter 11. Human serum albumin–based nanocarriers for drug delivery - p. 349 18. Chapter 12. Bovine serum albumin-based nanocarriers for drug delivery - p. 377 19. Chapter 13. Milk protein/casein-based nanocarriers for drug delivery - p. 409 20. Chapter 14. Silk-based nanocarriers for drug delivery - p. 435 21. Chapter 15. Zein-based nanocarriers for drug delivery - p. 465 22. Chapter 16. Gliadin-based nanocarriers for drug delivery - p. 499 23. Chapter 17. Lectin based nanocarriers for drug delivery - p. 519 24. Chapter 18. Elastin like polypeptides (ELPs) based nanocarriers for drug delivery - p. 547 25. Chapter 19. Virus-like particle (VLP)-based nanocarriers for drug delivery - p. 571 26. Chapter 20. The role of sol-gel routes in the nanoparticle–protein interactions in drug delivery systems - p. 611 27. Part III. Recent advances and regulatory aspects of protein-based nanoparticles in drug delivery - p. P3 28. Chapter 21. Recent advancement in the codelivery of proteins and small-molecule drugs for targeted therapy - p. 639 29. Chapter 22. Antibody–drug conjugated (ADC) nanoparticles for target-specific drug delivery nanocarriers in drug delivery - p. 667 30. Chapter 23. Recent updates in protein nanoparticle vaccine platforms - p. 691 31. Chapter 24. Recent advances in protein based nano delivery systems in overcoming the challenges associated with metastatic cancers - p. 723 32. 1 Introduction - p. 723 33. 2 Challenges in metastatic cancer treatment - p. 727 34. 3 Structural properties and mechanisms of drug delivery in protein-based nanoparticles - p. 730 35. 4 Mechanisms of drug delivery - p. 731 36. 5 Functional groups and their roles - p. 742 37. 6 Hydrophilicity and hydrophobicity applications in medicine - p. 744 38. 7 Future trends in drug delivery - p. 753 39. 8 Conclusion - p. 756 40. Chapter 25. Conclusion and future prospective of protein-based nanoparticles - p. 773 41. Index - p. 815
Protein-based Nanoparticles in Drug Delivery is a comprehensive book aimed at pharmaceutical scientists and researchers both in academia and corporate environments focused on nanotechnology drug delivery and pharmaceutical-related disciplines. The book covers the design and characterization of various protein nanoparticles, sheds light on the power of an endogenous substance as a drug delivery system, and highlights the possible future trends in the use of protein-based drug delivery. It covers in-depth novel applications of protein-based drug delivery from fundamental to most current use cases. The book comprises three parts. Part one is devoted to the foundations of protein-based drug delivery, including nanocarriers development, drug encapsulation, targetability, and in vivo properties. Part two explores the applications of protein-based nanoparticles in drug delivery, covering topics such as protein nanoparticles in cancer therapy, genetic material delivery, and nanocarriers based on milk protein, silk, and gliadin. Part three addresses recent advances and regulatory aspects of protein-based nanoparticles in drug delivery, including clinical translation, challenges, biological toxicity, and environmental hazards associated with protein-based nanoparticles. Protein-based Nanoparticles in Drug Delivery provides a complete journey of protein-based drug delivery, offers an in-depth understanding of the design and characterization of various protein nanoparticles, and highlights possible future trends in this field. Pharmaceutical scientists will benefit from the novel applications of protein-based nanoparticles drug delivery approaches in the biological field. Nanotechnologists, biologists, chemists, physicists, engineers, and clinicians will also benefit from the foundational content provided as a basis to support communication and tackle the multidisciplinary challenges associated with research in this exciting field.
1. Chapter 3. History, introduction, properties, and applications of protein-based drug delivery - p. 83 2. Chapter 4. Methods of preparation, characterization parameters, and pharmaceutical application for protein based nanoparticles - p. 113 3. Chapter 5. Design, development, and drug delivery applications of self-assembling nanocarriers from engineered proteins - p. 139 4. Chapter 6. Mechanism of protein-based nanoparticle interactions - p. 179 5. Part II. Applications of protein-based nanoparticles in drug delivery - p. P2 6. Chapter 7. Protein nanoparticles in cancer therapy - p. 211 7. 1 Introduction - p. 211 8. 2 Utilization of PNPs in cancer therapeutic modalities - p. 212 9. 3 Tumor-targeting strategies for PNP delivery - p. 217 10. 4 TME-responsive PNPs for cancer therapy - p. 218 11. 5 Protein nanoparticle platforms - p. 224 12. 6 Protein nanoparticles marketed and under clinical trial - p. 254 13. 7 Concluding remarks - p. 257 14. Chapter 8. Protein nanoparticles in cancer imaging - p. 273 15. Chapter 9. Protein-based nanotechnologies as cancer theranostics - p. 297 16. Chapter 10. Protein-based nanoparticles for the delivery of genetic materials - p. 327 17. Chapter 11. Human serum albumin–based nanocarriers for drug delivery - p. 349 18. Chapter 12. Bovine serum albumin-based nanocarriers for drug delivery - p. 377 19. Chapter 13. Milk protein/casein-based nanocarriers for drug delivery - p. 409 20. Chapter 14. Silk-based nanocarriers for drug delivery - p. 435 21. Chapter 15. Zein-based nanocarriers for drug delivery - p. 465 22. Chapter 16. Gliadin-based nanocarriers for drug delivery - p. 499 23. Chapter 17. Lectin based nanocarriers for drug delivery - p. 519 24. Chapter 18. Elastin like polypeptides (ELPs) based nanocarriers for drug delivery - p. 547 25. Chapter 19. Virus-like particle (VLP)-based nanocarriers for drug delivery - p. 571 26. Chapter 20. The role of sol-gel routes in the nanoparticle–protein interactions in drug delivery systems - p. 611 27. Part III. Recent advances and regulatory aspects of protein-based nanoparticles in drug delivery - p. P3 28. Chapter 21. Recent advancement in the codelivery of proteins and small-molecule drugs for targeted therapy - p. 639 29. Chapter 22. Antibody–drug conjugated (ADC) nanoparticles for target-specific drug delivery nanocarriers in drug delivery - p. 667 30. Chapter 23. Recent updates in protein nanoparticle vaccine platforms - p. 691 31. Chapter 24. Recent advances in protein based nano delivery systems in overcoming the challenges associated with metastatic cancers - p. 723 32. 1 Introduction - p. 723 33. 2 Challenges in metastatic cancer treatment - p. 727 34. 3 Structural properties and mechanisms of drug delivery in protein-based nanoparticles - p. 730 35. 4 Mechanisms of drug delivery - p. 731 36. 5 Functional groups and their roles - p. 742 37. 6 Hydrophilicity and hydrophobicity applications in medicine - p. 744 38. 7 Future trends in drug delivery - p. 753 39. 8 Conclusion - p. 756 40. Chapter 25. Conclusion and future prospective of protein-based nanoparticles - p. 773 41. Index - p. 815
