Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_ix 6. Chapter One: Transporter proteins and its implication in human diseases - p. page_1 7. Chapter Two: Protein kinase CK2 inhibition as a pharmacological strategy - p. page_23 8. Chapter Three: Emerging role of protein kinases in diabetes mellitus: From mechanism to therapy - p. page_47 9. Chapter Four: Dual roles of ATP-binding site in protein kinases: Orthosteric inhibition and allosteric regulation - p. page_87 10. Chapter Five: Pseudokinases: Prospects for expanding the therapeutic targets armamentarium - p. page_121 11. Chapter Six: Chemogenomics and bioinformatics approaches for prioritizing kinases as drug targets for neglected tropical diseases - p. page_187 12. Chapter Seven: Targeting malaria protein kinases - p. page_225 13. Chapter Eight: Yeast-based high-throughput screens for discovery of kinase inhibitors for neglected diseases - p. page_275 14. Chapter Nine: Structural studies of full-length receptor tyrosine kinases and their implications for drug design - p. page_311
Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_ix 6. Chapter One: Transporter proteins and its implication in human diseases - p. page_1 7. Chapter Two: Protein kinase CK2 inhibition as a pharmacological strategy - p. page_23 8. Chapter Three: Emerging role of protein kinases in diabetes mellitus: From mechanism to therapy - p. page_47 9. Chapter Four: Dual roles of ATP-binding site in protein kinases: Orthosteric inhibition and allosteric regulation - p. page_87 10. Chapter Five: Pseudokinases: Prospects for expanding the therapeutic targets armamentarium - p. page_121 11. Chapter Six: Chemogenomics and bioinformatics approaches for prioritizing kinases as drug targets for neglected tropical diseases - p. page_187 12. Chapter Seven: Targeting malaria protein kinases - p. page_225 13. Chapter Eight: Yeast-based high-throughput screens for discovery of kinase inhibitors for neglected diseases - p. page_275 14. Chapter Nine: Structural studies of full-length receptor tyrosine kinases and their implications for drug design - p. page_311
