Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation investigates the misfolding of proteins and implications for a variety of debilitating conditions. The book comprehensively overviews pathological protein aggregation, exploring its mechanisms in specific illnesses, including Alzheimer's disease, Parkinson’s disease, Huntington’s disease, prion diseases, ALS, and systemic amyloidosis. It addresses disrupted cellular pathways and failures in protein homeostasis during aging, delineating the unifying principles across protein conformational disorders. Sections feature structural insights into protein aggregates from amyloid fibrils to inclusion bodies and offer therapeutic strategies to disrupt aggregation pathways, enhance cellular protein quality control, and provide immunotherapy solutions.
Finally, the book closes with a discussion of the latest advances in research and considerations for future directions to combat protein aggregation. It will serve as an invaluable reference on the intricacies of protein misfolding and its clinical implications. Researchers, academics and graduate students working across these fields will benefit from this comprehensive guide. Additionally, clinicians and healthcare professionals will find it invaluable for understanding the molecular basis of protein misfolding disorders.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xi 7. About the editors - p. xv 8. Preface - p. xvii 9. Part I: Fundamentals of protein aggregation - p. P1 10. Chapter 1. Protein aggregation as a mechanistic consequence of proteostasis collapse and environmental-biophysical interactions - p. 3 11. Part II: Protein aggregation in neurodegenerative diseases - p. P41 12. Chapter 2. Protein aggregation in amyotrophic lateral sclerosis - p. 43 13. Chapter 3. Protein aggregation in prion diseases - p. 85 14. Chapter 4. Protein aggregation in Huntington's disease - p. 109 15. Chapter 5. Protein aggregation in Alzheimer's disease - p. 139 16. Chapter 6. Protein aggregation in Parkinson's disease - p. 173 17. Part III: Other protein aggregation diseases - p. P187 18. Chapter 7. Systemic amyloidosis: a comprehensive review of pathophysiology, diagnosis and contemporary management approaches - p. 189 19. Chapter 8. Protein aggregation and aging - p. 247 20. Part IV: Structural insights and therapeutic strategies - p. P295 21. Chapter 9. Structural insights into pathological protein aggregates: from amyloid fibrils to inclusion bodies - p. 297 22. Chapter 10. Therapeutic strategies against protein aggregation - p. 323 23. Chapter 11. Recent advances in protein aggregation research and future outlook - p. 349 24. Index - p. 367
Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation investigates the misfolding of proteins and implications for a variety of debilitating conditions. The book comprehensively overviews pathological protein aggregation, exploring its mechanisms in specific illnesses, including Alzheimer's disease, Parkinson’s disease, Huntington’s disease, prion diseases, ALS, and systemic amyloidosis. It addresses disrupted cellular pathways and failures in protein homeostasis during aging, delineating the unifying principles across protein conformational disorders. Sections feature structural insights into protein aggregates from amyloid fibrils to inclusion bodies and offer therapeutic strategies to disrupt aggregation pathways, enhance cellular protein quality control, and provide immunotherapy solutions.
Finally, the book closes with a discussion of the latest advances in research and considerations for future directions to combat protein aggregation. It will serve as an invaluable reference on the intricacies of protein misfolding and its clinical implications. Researchers, academics and graduate students working across these fields will benefit from this comprehensive guide. Additionally, clinicians and healthcare professionals will find it invaluable for understanding the molecular basis of protein misfolding disorders.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xi 7. About the editors - p. xv 8. Preface - p. xvii 9. Part I: Fundamentals of protein aggregation - p. P1 10. Chapter 1. Protein aggregation as a mechanistic consequence of proteostasis collapse and environmental-biophysical interactions - p. 3 11. Part II: Protein aggregation in neurodegenerative diseases - p. P41 12. Chapter 2. Protein aggregation in amyotrophic lateral sclerosis - p. 43 13. Chapter 3. Protein aggregation in prion diseases - p. 85 14. Chapter 4. Protein aggregation in Huntington's disease - p. 109 15. Chapter 5. Protein aggregation in Alzheimer's disease - p. 139 16. Chapter 6. Protein aggregation in Parkinson's disease - p. 173 17. Part III: Other protein aggregation diseases - p. P187 18. Chapter 7. Systemic amyloidosis: a comprehensive review of pathophysiology, diagnosis and contemporary management approaches - p. 189 19. Chapter 8. Protein aggregation and aging - p. 247 20. Part IV: Structural insights and therapeutic strategies - p. P295 21. Chapter 9. Structural insights into pathological protein aggregates: from amyloid fibrils to inclusion bodies - p. 297 22. Chapter 10. Therapeutic strategies against protein aggregation - p. 323 23. Chapter 11. Recent advances in protein aggregation research and future outlook - p. 349 24. Index - p. 367
