Protein Misfolding Diseases, delves into the intricate molecular mechanisms behind a class of devastating disorders caused by abnormal protein folding. This comprehensive book explores interesting and updated topics, including Protein misfolding in hemophilia, Characterizing Protein Misfolding: Inside and Out, Heat Shock proteins (HSPs) as chaperones for Oncogenesis, Protein Misfolding and Cancer: Molecular Insights and Future Perspectives, Proteostasis and Pathogenesis: Unraveling the Complexity of Protein Misfolding Disorders, Small molecule inhibitors targeting α-synuclein aggregation: Progress and future outlook, and much more.
Additional sections cover Chaperone Machinery in Neurodegeneration: A Spotlight on Protein Misfolding Diseases and Calpain- mediated proteolytic cleavage.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. xv 7. Chapter One: Protein misfolding in hemophilia - p. 1 8. Chapter Two: Unraveling tau’s fold: Structural dynamics in Alzheimer’s pathogenesis - p. 29 9. Chapter Three: The cross talk between protein misfolding and tumor microenvironment dynamics - p. 57 10. Chapter Four: Protein misfolding and cancer - proteomics as an approach for biomarker discovery - p. 97 11. Chapter Five: Protein misfolding and unfolded protein response in cancer: Current updates with focus on epigenetic regulation - p. 117 12. Chapter Six: Protein misfolding and neurodegeneration: Mechanisms, implications, and therapeutic strategies - p. 135 13. Chapter Seven: Unravelling the p53 misfolding by chaperones in cancer - p. 179 14. Chapter Eight: Heat shock proteins (HSPs) as chaperones for oncogenesis - p. 229 15. Chapter Nine: p53 Aggregation in cancer: Molecular mechanisms, functional disruptions, and targeted therapies - p. 255 16. Chapter Ten: Proteostasis and pathogenesis: Unraveling the complexity of protein misfolding disorders - p. 299 17. Chapter Eleven: Protein misfolding and its dual role in neurodegeneration and cancer progression - p. 355 18. Chapter Twelve: Small molecule inhibitors targeting alpha-synuclein aggregation: Progress and future outlook - p. 379 19. Chapter Thirteen: Chaperone machinery in neurodegeneration: A spotlight on protein misfolding diseases - p. 455 20. Chapter Fourteen: The calpain-mediated proteolytic cleavage peptide P10 modulates Tau phosphorylation in Alzheimer’s disease - p. 481 21. Chapter Fifteen: Hypoxia-driven perturbations of proteostasis and therapeutic vulnerabilities in cancer - p. 507
Protein Misfolding Diseases, delves into the intricate molecular mechanisms behind a class of devastating disorders caused by abnormal protein folding. This comprehensive book explores interesting and updated topics, including Protein misfolding in hemophilia, Characterizing Protein Misfolding: Inside and Out, Heat Shock proteins (HSPs) as chaperones for Oncogenesis, Protein Misfolding and Cancer: Molecular Insights and Future Perspectives, Proteostasis and Pathogenesis: Unraveling the Complexity of Protein Misfolding Disorders, Small molecule inhibitors targeting α-synuclein aggregation: Progress and future outlook, and much more.
Additional sections cover Chaperone Machinery in Neurodegeneration: A Spotlight on Protein Misfolding Diseases and Calpain- mediated proteolytic cleavage.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. xv 7. Chapter One: Protein misfolding in hemophilia - p. 1 8. Chapter Two: Unraveling tau’s fold: Structural dynamics in Alzheimer’s pathogenesis - p. 29 9. Chapter Three: The cross talk between protein misfolding and tumor microenvironment dynamics - p. 57 10. Chapter Four: Protein misfolding and cancer - proteomics as an approach for biomarker discovery - p. 97 11. Chapter Five: Protein misfolding and unfolded protein response in cancer: Current updates with focus on epigenetic regulation - p. 117 12. Chapter Six: Protein misfolding and neurodegeneration: Mechanisms, implications, and therapeutic strategies - p. 135 13. Chapter Seven: Unravelling the p53 misfolding by chaperones in cancer - p. 179 14. Chapter Eight: Heat shock proteins (HSPs) as chaperones for oncogenesis - p. 229 15. Chapter Nine: p53 Aggregation in cancer: Molecular mechanisms, functional disruptions, and targeted therapies - p. 255 16. Chapter Ten: Proteostasis and pathogenesis: Unraveling the complexity of protein misfolding disorders - p. 299 17. Chapter Eleven: Protein misfolding and its dual role in neurodegeneration and cancer progression - p. 355 18. Chapter Twelve: Small molecule inhibitors targeting alpha-synuclein aggregation: Progress and future outlook - p. 379 19. Chapter Thirteen: Chaperone machinery in neurodegeneration: A spotlight on protein misfolding diseases - p. 455 20. Chapter Fourteen: The calpain-mediated proteolytic cleavage peptide P10 modulates Tau phosphorylation in Alzheimer’s disease - p. 481 21. Chapter Fifteen: Hypoxia-driven perturbations of proteostasis and therapeutic vulnerabilities in cancer - p. 507
