In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called ‘protease web’, and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events.
1. Chapter 1. Proteolytic signaling: An introduction - p. 1 2. Chapter 2. Ubiquitin ligases: Proteolytic signaling, protein turnover, and disease - p. 11 3. Chapter 3. Lysosomal proteases and their role in signaling pathways - p. 41 4. Chapter 4. Antigen processing and presentation through MHC molecules - p. 63 5. Chapter 5. Proteolytic processing in autophagy - p. 81 6. Chapter 6. Proteases are cut out to regulate acute and chronic inflammation - p. 93 7. Chapter 7. Proteolytic processing of laminin and the role of cryptides in tumoral biology - p. 113 8. Chapter 8. Proteolytic signaling in cutaneous wound healing - p. 131 9. Chapter 9. Proteinase imbalance in oral cancer and other diseases - p. 182 10. Chapter 10. “Omics” approaches to determine protease degradomes in complex biological matrices - p. 209 11. Chapter 11. The protease web - p. 229 12. The puzzle of proteolytic effects in hemorrhage induced by Viperidae snake venom metalloproteinases - p. 256 13. Index - p. 285
In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called ‘protease web’, and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events.
1. Chapter 1. Proteolytic signaling: An introduction - p. 1 2. Chapter 2. Ubiquitin ligases: Proteolytic signaling, protein turnover, and disease - p. 11 3. Chapter 3. Lysosomal proteases and their role in signaling pathways - p. 41 4. Chapter 4. Antigen processing and presentation through MHC molecules - p. 63 5. Chapter 5. Proteolytic processing in autophagy - p. 81 6. Chapter 6. Proteases are cut out to regulate acute and chronic inflammation - p. 93 7. Chapter 7. Proteolytic processing of laminin and the role of cryptides in tumoral biology - p. 113 8. Chapter 8. Proteolytic signaling in cutaneous wound healing - p. 131 9. Chapter 9. Proteinase imbalance in oral cancer and other diseases - p. 182 10. Chapter 10. “Omics” approaches to determine protease degradomes in complex biological matrices - p. 209 11. Chapter 11. The protease web - p. 229 12. The puzzle of proteolytic effects in hemorrhage induced by Viperidae snake venom metalloproteinases - p. 256 13. Index - p. 285
