Quantitative Human Physiology: An Introduction, Third Edition, winner of a 2018 Textbook Excellence Award (Texty), is the first text to meet the needs of the undergraduate bioengineering student who is being exposed to physiology for the first time but requires a more analytical/quantitative approach. This book explores how component behavior produces system behavior in physiological systems. Through text explanation, figures, and equations, it provides the engineering student with a basic understanding of physiological principles, with an emphasis on quantitative aspects. The third edition has been revised with more and expanded problem sets and improved illustrations.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Preface - p. ix 7. Unit 1: Physical and Chemical Foundations of Physiology - p. U1 8. Chapter 1.1. The Core Principles of Physiology - p. 3 9. Chapter 1.2. Physical Foundations of Physiology 1: Pressure-Driven Flow - p. 16 10. Chapter 1.3. Physical Foundations of Physiology 2: Electrical Force, Potential, Capacitance, and Current - p. 32 11. Chapter 1.4. Chemical Foundations of Physiology 1: Chemical Energy and Intermolecular Forces - p. 50 12. Problem Set 1.PS1. Physical Foundations: Pressure and Electrical Forces and Flows - p. 46 13. Chapter 1.5. Chemical Foundations of Physiology 2: Concentration and Kinetics - p. 64 14. Chapter 1.6. Diffusion - p. 80 15. Chapter 1.7. Electrochemical Potential and Free Energy - p. 92 16. Problem Set 1.PS2. Kinetics and Diffusion - p. 102 17. Unit 2: Membranes Transport and Metabolism - p. U107 18. Chapter 2.1. Cell Structure - p. 109 19. Chapter 2.2. DNA and Protein Synthesis - p. 143 20. Chapter 2.3. Regulation of Gene Transcription - p. 155 21. Chapter 2.4. Protein Structure - p. 169 22. Chapter 2.5. Biological Membranes - p. 187 23. Problem Set 2.PS1. Surface Tension, Membrane Structure, Microscopic Resolution, and Cell Fractionation - p. 202 24. Chapter 2.6. Passive Transport and Facilitated Diffusion - p. 207 25. Chapter 2.7. Active Transport: Pumps and Exchangers - p. 217 26. Chapter 2.8. Osmosis and Osmotic Pressure - p. 231 27. Chapter 2.9. Gibbs–Donnan Equilibrium and Cell Volume Regulation - p. 248 28. Problem Set 2.PS2. Membrane Transport - p. 263 29. Chapter 2.10. Cell Signaling - p. 269 30. Chapter 2.11. ATP Production I: Glycolysis - p. 289 31. Chapter 2.12. ATP Production II: The TCA Cycle and Oxidative Phosphorylation - p. 304 32. Chapter 2.13. ATP Production III: Fatty Acid Oxidation and Amino Acid Oxidation - p. 319 33. Unit 3: Physiology of Excitable Cells - p. U335 34. Chapter 3.1. The Origin of the Membrane Potential - p. 337 35. Chapter 3.2. The Action Potential - p. 348 36. Chapter 3.3. Propagation of the Action Potential - p. 365 37. Problem Set 3.PS1. Membrane Potential Action Potential and Nerve Conduction - p. 375 38. Chapter 3.4. Skeletal Muscle Mechanics - p. 378 39. Chapter 3.5. Contractile Mechanisms in Skeletal Muscle - p. 394 40. Chapter 3.6. The Neuromuscular Junction and Excitation-Contraction Coupling - p. 409 41. Chapter 3.7. Muscle Energetics and Fatigue - p. 428 42. Problem Set 3.PS2. Neuromuscular Transmission, Muscle Force, and Energetics - p. 444 43. Chapter 3.8. Smooth Muscle - p. 446 44. Unit 4: The Nervous System - p. U459 45. Chapter 4.1. Organization of the Nervous System - p. 461 46. Chapter 4.2. Cells, Synapses, and Neurotransmitters - p. 478 47. Chapter 4.3. Introductory Sensory Physiology and Cutaneous Sensory Systems - p. 500 48. Chapter 4.4. Spinal Reflexes and Control of Movement - p. 527 49. Chapter 4.5. Control of Movement - p. 542 50. Chapter 4.6. The Sense of Balance - p. 557 51. Problem Set 4.PS1. Nerve Conduction - p. 572 52. Chapter 4.7. Hearing - p. 577 53. Chapter 4.8. The Chemical Senses - p. 599 54. Chapter 4.9. Vision: Optics and Phototransduction - p. 615 55. Problem Set 4.PS2. Sensory Transduction - p. 630 56. Chapter 4.10. Vision II: Retinal and Central Image Processing - p. 632 57. Chapter 4.11. The Autonomic Nervous System - p. 650 58. Unit 5: The Cardiovascular System - p. U667 59. Chapter 5.1. Overview of the Cardiovascular System and Blood Clotting - p. 669 60. Chapter 5.2. Plasma and Red Blood Cells - p. 685 61. Chapter 5.3. White Blood Cells and Innate Immunity - p. 701 62. Chapter 5.4. Inflammation - p. 716 63. Chapter 5.5. Adaptive Immunity - p. 730 64. Problem Set 5.PS1. Blood - p. 742 65. Chapter 5.6. The Heart as a Pump - p. 745 66. Chapter 5.7. The Cardiac Action Potential - p. 755 67. Chapter 5.8. The Electrocardiogram - p. 768 68. Chapter 5.9. The Cellular Basis of Cardiac Contractility - p. 779 69. Chapter 5.10. The Cardiac Function Curve - p. 797 70. Problem Set 5.PS2. Cardiac Work and Ecg - p. 811 71. Chapter 5.11. Vascular Function: Hemodynamics - p. 814 72. Chapter 5.12. Microcirculation and Solute Exchange - p. 826 73. Chapter 5.13. Regulation of Perfusion - p. 839 74. Chapter 5.14. Integration of Cardiac Output and Venous Return - p. 851 75. Chapter 5.15. Regulation of Arterial Pressure - p. 862 76. Problem Set 5.PS3. Hemodynamics and Microcirculation - p. 876 77. Unit 6: Respiratory Physiology - p. U879 78. Chapter 6.1. The Mechanics of Breathing - p. 881 79. Chapter 6.2. Lung Volumes and Airway Resistance - p. 893 80. Chapter 6.3. Gas Exchange in the Lungs - p. 904 81. Problem Set 6.PS1. Airway Resistance and Alveolar Gas Exchange - p. 917 82. Chapter 6.4. Oxygen and Carbon Dioxide Transport - p. 920 83. Chapter 6.5. Acid–Base Physiology I:The Bicarbonate Buffer System and Respiratory Compensation - p. 929 84. Chapter 6.6. Control of Ventilation - p. 942 85. Problem Set 6.PS2. Gas Transport and PH Disturbances - p. 957 86. Unit 7: Renal Physiology - p. U961 87. Chapter 7.1. Body Fluid Compartments - p. 963 88. Chapter 7.2. Functional Anatomy of the Kidneys and Overview of Kidney Function - p. 975 89. Chapter 7.3. Glomerular Filtration - p. 984 90. Problem Set 7.PS1. Fluid Volumes, Glomerular Filtration, and Clearance - p. 996 91. Chapter 7.4. Tubular Reabsorption and Secretion - p. 1001 92. Chapter 7.5. Concentration and Dilution of Urine - p. 1013 93. Chapter 7.6. Regulation of Fluid Balance - p. 1026 94. Chapter 7.7. Renal Component of Acid–Base Balance - p. 1040 95. Problem Set 7.PS2. Fluid and Electrolyte Balance and Acid–Base Balance - p. 1054 96. Unit 8: Gastrointestinal Physiology - p. U1057 97. Chapter 8.1. The Mouth and Esophagus - p. 1059 98. Chapter 8.2. The Stomach - p. 1075 99. Chapter 8.3. Intestinal and Colonic Chemoreception and Motility - p. 1088 100. Chapter 8.4. Pancreatic and Biliary Secretion - p. 1106 101. Chapter 8.5. Digestion and Absorption of the Macronutrients - p. 1118 102. Chapter 8.6. Energy Balance and Regulation of Food Intake - p. 1133 103. Problem Set 8.Ps1. Energy Balance - p. 1151 104. Unit 9: Endocrine Physiology - p. U1153 105. Chapter 9.1. General Principles of Endocrinology - p. 1155 106. Chapter 9.2. Hypothalamus and Pituitary Gland - p. 1174 107. Chapter 9.3. The Thyroid Gland - p. 1189 108. Chapter 9.4. The Endocrine Pancreas - p. 1204 109. Chapter 9.5. The Adrenal Cortex - p. 1221 110. Chapter 9.6. The Adrenal Medulla and Integration of Metabolic Control - p. 1234 111. Chapter 9.7. Calcium and Phosphorus Homeostasis I: The Calciotropic Hormones - p. 1243 112. Chapter 9.8. Calcium and Phosphorus Homeostasis II: Target Tissues and Integrated Control - p. 1254 113. Chapter 9.9. Female Reproductive Physiology - p. 1271 114. Chapter 9.10. Male Reproductive Physiology - p. 1289 115. Problem Set 9.PS1. Ligand Binding - p. 1302 116. Index - p. 1319 117. Appendix I. Important Equations - p. 1304 118. Appendix II. Important Physical Constants for Physiology - p. 1318
Quantitative Human Physiology: An Introduction, Third Edition, winner of a 2018 Textbook Excellence Award (Texty), is the first text to meet the needs of the undergraduate bioengineering student who is being exposed to physiology for the first time but requires a more analytical/quantitative approach. This book explores how component behavior produces system behavior in physiological systems. Through text explanation, figures, and equations, it provides the engineering student with a basic understanding of physiological principles, with an emphasis on quantitative aspects. The third edition has been revised with more and expanded problem sets and improved illustrations.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Preface - p. ix 7. Unit 1: Physical and Chemical Foundations of Physiology - p. U1 8. Chapter 1.1. The Core Principles of Physiology - p. 3 9. Chapter 1.2. Physical Foundations of Physiology 1: Pressure-Driven Flow - p. 16 10. Chapter 1.3. Physical Foundations of Physiology 2: Electrical Force, Potential, Capacitance, and Current - p. 32 11. Chapter 1.4. Chemical Foundations of Physiology 1: Chemical Energy and Intermolecular Forces - p. 50 12. Problem Set 1.PS1. Physical Foundations: Pressure and Electrical Forces and Flows - p. 46 13. Chapter 1.5. Chemical Foundations of Physiology 2: Concentration and Kinetics - p. 64 14. Chapter 1.6. Diffusion - p. 80 15. Chapter 1.7. Electrochemical Potential and Free Energy - p. 92 16. Problem Set 1.PS2. Kinetics and Diffusion - p. 102 17. Unit 2: Membranes Transport and Metabolism - p. U107 18. Chapter 2.1. Cell Structure - p. 109 19. Chapter 2.2. DNA and Protein Synthesis - p. 143 20. Chapter 2.3. Regulation of Gene Transcription - p. 155 21. Chapter 2.4. Protein Structure - p. 169 22. Chapter 2.5. Biological Membranes - p. 187 23. Problem Set 2.PS1. Surface Tension, Membrane Structure, Microscopic Resolution, and Cell Fractionation - p. 202 24. Chapter 2.6. Passive Transport and Facilitated Diffusion - p. 207 25. Chapter 2.7. Active Transport: Pumps and Exchangers - p. 217 26. Chapter 2.8. Osmosis and Osmotic Pressure - p. 231 27. Chapter 2.9. Gibbs–Donnan Equilibrium and Cell Volume Regulation - p. 248 28. Problem Set 2.PS2. Membrane Transport - p. 263 29. Chapter 2.10. Cell Signaling - p. 269 30. Chapter 2.11. ATP Production I: Glycolysis - p. 289 31. Chapter 2.12. ATP Production II: The TCA Cycle and Oxidative Phosphorylation - p. 304 32. Chapter 2.13. ATP Production III: Fatty Acid Oxidation and Amino Acid Oxidation - p. 319 33. Unit 3: Physiology of Excitable Cells - p. U335 34. Chapter 3.1. The Origin of the Membrane Potential - p. 337 35. Chapter 3.2. The Action Potential - p. 348 36. Chapter 3.3. Propagation of the Action Potential - p. 365 37. Problem Set 3.PS1. Membrane Potential Action Potential and Nerve Conduction - p. 375 38. Chapter 3.4. Skeletal Muscle Mechanics - p. 378 39. Chapter 3.5. Contractile Mechanisms in Skeletal Muscle - p. 394 40. Chapter 3.6. The Neuromuscular Junction and Excitation-Contraction Coupling - p. 409 41. Chapter 3.7. Muscle Energetics and Fatigue - p. 428 42. Problem Set 3.PS2. Neuromuscular Transmission, Muscle Force, and Energetics - p. 444 43. Chapter 3.8. Smooth Muscle - p. 446 44. Unit 4: The Nervous System - p. U459 45. Chapter 4.1. Organization of the Nervous System - p. 461 46. Chapter 4.2. Cells, Synapses, and Neurotransmitters - p. 478 47. Chapter 4.3. Introductory Sensory Physiology and Cutaneous Sensory Systems - p. 500 48. Chapter 4.4. Spinal Reflexes and Control of Movement - p. 527 49. Chapter 4.5. Control of Movement - p. 542 50. Chapter 4.6. The Sense of Balance - p. 557 51. Problem Set 4.PS1. Nerve Conduction - p. 572 52. Chapter 4.7. Hearing - p. 577 53. Chapter 4.8. The Chemical Senses - p. 599 54. Chapter 4.9. Vision: Optics and Phototransduction - p. 615 55. Problem Set 4.PS2. Sensory Transduction - p. 630 56. Chapter 4.10. Vision II: Retinal and Central Image Processing - p. 632 57. Chapter 4.11. The Autonomic Nervous System - p. 650 58. Unit 5: The Cardiovascular System - p. U667 59. Chapter 5.1. Overview of the Cardiovascular System and Blood Clotting - p. 669 60. Chapter 5.2. Plasma and Red Blood Cells - p. 685 61. Chapter 5.3. White Blood Cells and Innate Immunity - p. 701 62. Chapter 5.4. Inflammation - p. 716 63. Chapter 5.5. Adaptive Immunity - p. 730 64. Problem Set 5.PS1. Blood - p. 742 65. Chapter 5.6. The Heart as a Pump - p. 745 66. Chapter 5.7. The Cardiac Action Potential - p. 755 67. Chapter 5.8. The Electrocardiogram - p. 768 68. Chapter 5.9. The Cellular Basis of Cardiac Contractility - p. 779 69. Chapter 5.10. The Cardiac Function Curve - p. 797 70. Problem Set 5.PS2. Cardiac Work and Ecg - p. 811 71. Chapter 5.11. Vascular Function: Hemodynamics - p. 814 72. Chapter 5.12. Microcirculation and Solute Exchange - p. 826 73. Chapter 5.13. Regulation of Perfusion - p. 839 74. Chapter 5.14. Integration of Cardiac Output and Venous Return - p. 851 75. Chapter 5.15. Regulation of Arterial Pressure - p. 862 76. Problem Set 5.PS3. Hemodynamics and Microcirculation - p. 876 77. Unit 6: Respiratory Physiology - p. U879 78. Chapter 6.1. The Mechanics of Breathing - p. 881 79. Chapter 6.2. Lung Volumes and Airway Resistance - p. 893 80. Chapter 6.3. Gas Exchange in the Lungs - p. 904 81. Problem Set 6.PS1. Airway Resistance and Alveolar Gas Exchange - p. 917 82. Chapter 6.4. Oxygen and Carbon Dioxide Transport - p. 920 83. Chapter 6.5. Acid–Base Physiology I:The Bicarbonate Buffer System and Respiratory Compensation - p. 929 84. Chapter 6.6. Control of Ventilation - p. 942 85. Problem Set 6.PS2. Gas Transport and PH Disturbances - p. 957 86. Unit 7: Renal Physiology - p. U961 87. Chapter 7.1. Body Fluid Compartments - p. 963 88. Chapter 7.2. Functional Anatomy of the Kidneys and Overview of Kidney Function - p. 975 89. Chapter 7.3. Glomerular Filtration - p. 984 90. Problem Set 7.PS1. Fluid Volumes, Glomerular Filtration, and Clearance - p. 996 91. Chapter 7.4. Tubular Reabsorption and Secretion - p. 1001 92. Chapter 7.5. Concentration and Dilution of Urine - p. 1013 93. Chapter 7.6. Regulation of Fluid Balance - p. 1026 94. Chapter 7.7. Renal Component of Acid–Base Balance - p. 1040 95. Problem Set 7.PS2. Fluid and Electrolyte Balance and Acid–Base Balance - p. 1054 96. Unit 8: Gastrointestinal Physiology - p. U1057 97. Chapter 8.1. The Mouth and Esophagus - p. 1059 98. Chapter 8.2. The Stomach - p. 1075 99. Chapter 8.3. Intestinal and Colonic Chemoreception and Motility - p. 1088 100. Chapter 8.4. Pancreatic and Biliary Secretion - p. 1106 101. Chapter 8.5. Digestion and Absorption of the Macronutrients - p. 1118 102. Chapter 8.6. Energy Balance and Regulation of Food Intake - p. 1133 103. Problem Set 8.Ps1. Energy Balance - p. 1151 104. Unit 9: Endocrine Physiology - p. U1153 105. Chapter 9.1. General Principles of Endocrinology - p. 1155 106. Chapter 9.2. Hypothalamus and Pituitary Gland - p. 1174 107. Chapter 9.3. The Thyroid Gland - p. 1189 108. Chapter 9.4. The Endocrine Pancreas - p. 1204 109. Chapter 9.5. The Adrenal Cortex - p. 1221 110. Chapter 9.6. The Adrenal Medulla and Integration of Metabolic Control - p. 1234 111. Chapter 9.7. Calcium and Phosphorus Homeostasis I: The Calciotropic Hormones - p. 1243 112. Chapter 9.8. Calcium and Phosphorus Homeostasis II: Target Tissues and Integrated Control - p. 1254 113. Chapter 9.9. Female Reproductive Physiology - p. 1271 114. Chapter 9.10. Male Reproductive Physiology - p. 1289 115. Problem Set 9.PS1. Ligand Binding - p. 1302 116. Index - p. 1319 117. Appendix I. Important Equations - p. 1304 118. Appendix II. Important Physical Constants for Physiology - p. 1318
