Rang and Dale’s Pharmacology is internationally acknowledged as the core textbook for students of pharmacology, and has provided accessible, up-to-date information on drugs and their mechanism of action for more than 30 years.Now in its tenth edition, it has been updated to include important new drugs such as gene therapies, personalised medicines and the new wave of RNA drugs. However it has not lost any of the elements that have contributed to its popularity, such as color coding and illustrations, making it reader-friendly while comprehensively covering the depth of detail required.This essential book is recommended as the first-choice undergraduate text for science and medical students and junior doctors and will also be useful for students in other professional disciplines such as pharmacy, veterinary medicine and nursing.
1. Instructions for online access - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. How to Use - p. iii 6. Copyright - p. iv 7. Video and Case Study Contents - p. xv 8. Inflammation case study - p. xv.ei 9. Cardiovascular case study - p. xv.eii 10. Respiratory case study - p. xv.eiii 11. Food and glucose regulation case study - p. xv.eiv 12. Neurodegenerative disease case study - p. xv.evi 13. Epilepsy case study - p. xv.eviii 14. Cancer case study - p. xv.eix 15. Videos Contents - p. xv.eix 16. Rang & Dale’s Pharmacology Tenth Edition Preface - p. xvi 17. Section 1. GENERAL PRINCIPLES - p. xvi 18. 1. What is pharmacology? - p. 1 19. 2. How drugs act: general principles - p. 6 20. 3. How drugs act: molecular aspects - p. 24 21. 4. How drugs act: cellular aspects – excitation, contraction and secretion - p. 54 22. 5. How drugs act: biopharmaceuticals and gene therapy - p. 72 23. 6. Cell proliferation, apoptosis, repair and regeneration - p. 87 24. 7. Cellular mechanisms: host defence - p. 98 25. 8. Method and measurement in pharmacology - p. 112 26. 9. Absorption and distribution of drugs - p. 123 27. 10. Drug metabolism and elimination - p. 140 28. 11. Pharmacokinetics - p. 150 29. 12. Individual variation, pharmacogenomics and personalised medicine - p. 160 30. Section 2. CHEMICAL MEDIATORS - p. 169.e2 31. 13. Chemical mediators and the autonomic nervous system - p. 170 32. 14. Cholinergic transmission - p. 182 33. 15. Noradrenergic transmission - p. 205 34. 16. 5-Hydroxytryptamine and the purines - p. 225 35. 17. Local hormones: histamine, lipids, peptides and proteins - p. 237 36. 18. Cannabinoids - p. 260 37. 19. Nitric oxide and related mediators - p. 267 38. Section 3. DRUGS AFFECTING MAJOR ORGAN SYSTEMS - p. 274.e2 39. 20. The heart - p. 275 40. 21. The vascular system - p. 294 41. 22. Atherosclerosis and lipoprotein metabolism - p. 313 42. 23. Haemostasis and thrombosis - p. 322 43. 24. Haematopoietic system and treatment of anaemia - p. 337 44. 25. Anti-inflammatory and immunosuppressant drugs - p. 350 45. 26. Skin - p. 371 46. 27. The eye - p. 384 47. 28. Respiratory system - p. 390 48. 29. The kidney and urinary system - p. 402 49. 30. The gastrointestinal tract - p. 416 50. 31. The control of blood glucose and drug treatment of diabetes mellitus - p. 429 51. 32. Obesity - p. 443 52. 33. The pituitary and the adrenal cortex - p. 452 53. 34. The thyroid - p. 469 54. 35. The reproductive system - p. 476 55. 36. Bone metabolism - p. 491 56. Section 4. NERVOUS SYSTEM - p. 500.e2 57. 37. Chemical transmission and drug action in the central nervous system - p. 501 58. 38. Amino acid transmitters - p. 509 59. 39. Other transmitters and modulators - p. 524 60. 40. Neurodegenerative diseases - p. 539 61. 41. General anaesthetic agents - p. 557 62. 42. Headache - p. 568 63. 43. Analgesic drugs - p. 575 64. 44. Local anaesthetics and other drugs affecting sodium channels - p. 595 65. 45. Anxiolytic and hypnotic drugs - p. 602 66. 46. Antiepileptic drugs - p. 613 67. 47. Antipsychotic drugs - p. 626 68. 48. Antidepressant drugs - p. 640 69. 49. Psychoactive drugs - p. 663 70. 50. Drug use and addiction - p. 683 71. Section 5. DRUGS USED FOR THE TREATMENT OF INFECTIONS AND CANCER - p. 689.e2 72. 51. Basic principles of antimicrobial chemotherapy - p. 690 73. 52. Antibacterial drugs - p. 704 74. 53. Antiviral drugs - p. 721 75. 54. Antifungal drugs - p. 736 76. 55. Antiprotozoal drugs - p. 742 77. 56. Antihelminthic drugs - p. 757 78. 57. Anticancer drugs - p. 764 79. Section 6. SPECIAL TOPICS - p. 782.e2 80. 58. Harmful effects of drugs - p. 783 81. 59. Lifestyle and drugs in sport - p. 794 82. 60. Drug discovery and development - p. 802 83. Index - p. 811.e2
Rang and Dale’s Pharmacology is internationally acknowledged as the core textbook for students of pharmacology, and has provided accessible, up-to-date information on drugs and their mechanism of action for more than 30 years.Now in its tenth edition, it has been updated to include important new drugs such as gene therapies, personalised medicines and the new wave of RNA drugs. However it has not lost any of the elements that have contributed to its popularity, such as color coding and illustrations, making it reader-friendly while comprehensively covering the depth of detail required.This essential book is recommended as the first-choice undergraduate text for science and medical students and junior doctors and will also be useful for students in other professional disciplines such as pharmacy, veterinary medicine and nursing.
1. Instructions for online access - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. How to Use - p. iii 6. Copyright - p. iv 7. Video and Case Study Contents - p. xv 8. Inflammation case study - p. xv.ei 9. Cardiovascular case study - p. xv.eii 10. Respiratory case study - p. xv.eiii 11. Food and glucose regulation case study - p. xv.eiv 12. Neurodegenerative disease case study - p. xv.evi 13. Epilepsy case study - p. xv.eviii 14. Cancer case study - p. xv.eix 15. Videos Contents - p. xv.eix 16. Rang & Dale’s Pharmacology Tenth Edition Preface - p. xvi 17. Section 1. GENERAL PRINCIPLES - p. xvi 18. 1. What is pharmacology? - p. 1 19. 2. How drugs act: general principles - p. 6 20. 3. How drugs act: molecular aspects - p. 24 21. 4. How drugs act: cellular aspects – excitation, contraction and secretion - p. 54 22. 5. How drugs act: biopharmaceuticals and gene therapy - p. 72 23. 6. Cell proliferation, apoptosis, repair and regeneration - p. 87 24. 7. Cellular mechanisms: host defence - p. 98 25. 8. Method and measurement in pharmacology - p. 112 26. 9. Absorption and distribution of drugs - p. 123 27. 10. Drug metabolism and elimination - p. 140 28. 11. Pharmacokinetics - p. 150 29. 12. Individual variation, pharmacogenomics and personalised medicine - p. 160 30. Section 2. CHEMICAL MEDIATORS - p. 169.e2 31. 13. Chemical mediators and the autonomic nervous system - p. 170 32. 14. Cholinergic transmission - p. 182 33. 15. Noradrenergic transmission - p. 205 34. 16. 5-Hydroxytryptamine and the purines - p. 225 35. 17. Local hormones: histamine, lipids, peptides and proteins - p. 237 36. 18. Cannabinoids - p. 260 37. 19. Nitric oxide and related mediators - p. 267 38. Section 3. DRUGS AFFECTING MAJOR ORGAN SYSTEMS - p. 274.e2 39. 20. The heart - p. 275 40. 21. The vascular system - p. 294 41. 22. Atherosclerosis and lipoprotein metabolism - p. 313 42. 23. Haemostasis and thrombosis - p. 322 43. 24. Haematopoietic system and treatment of anaemia - p. 337 44. 25. Anti-inflammatory and immunosuppressant drugs - p. 350 45. 26. Skin - p. 371 46. 27. The eye - p. 384 47. 28. Respiratory system - p. 390 48. 29. The kidney and urinary system - p. 402 49. 30. The gastrointestinal tract - p. 416 50. 31. The control of blood glucose and drug treatment of diabetes mellitus - p. 429 51. 32. Obesity - p. 443 52. 33. The pituitary and the adrenal cortex - p. 452 53. 34. The thyroid - p. 469 54. 35. The reproductive system - p. 476 55. 36. Bone metabolism - p. 491 56. Section 4. NERVOUS SYSTEM - p. 500.e2 57. 37. Chemical transmission and drug action in the central nervous system - p. 501 58. 38. Amino acid transmitters - p. 509 59. 39. Other transmitters and modulators - p. 524 60. 40. Neurodegenerative diseases - p. 539 61. 41. General anaesthetic agents - p. 557 62. 42. Headache - p. 568 63. 43. Analgesic drugs - p. 575 64. 44. Local anaesthetics and other drugs affecting sodium channels - p. 595 65. 45. Anxiolytic and hypnotic drugs - p. 602 66. 46. Antiepileptic drugs - p. 613 67. 47. Antipsychotic drugs - p. 626 68. 48. Antidepressant drugs - p. 640 69. 49. Psychoactive drugs - p. 663 70. 50. Drug use and addiction - p. 683 71. Section 5. DRUGS USED FOR THE TREATMENT OF INFECTIONS AND CANCER - p. 689.e2 72. 51. Basic principles of antimicrobial chemotherapy - p. 690 73. 52. Antibacterial drugs - p. 704 74. 53. Antiviral drugs - p. 721 75. 54. Antifungal drugs - p. 736 76. 55. Antiprotozoal drugs - p. 742 77. 56. Antihelminthic drugs - p. 757 78. 57. Anticancer drugs - p. 764 79. Section 6. SPECIAL TOPICS - p. 782.e2 80. 58. Harmful effects of drugs - p. 783 81. 59. Lifestyle and drugs in sport - p. 794 82. 60. Drug discovery and development - p. 802 83. Index - p. 811.e2
