Rang and Dale’s Pharmacology is internationally acknowledged as the core textbook for students of pharmacology, and has provided accessible, up-to-date information on drugs and their mechanism of action for more than 30 years.Now in its tenth edition, it has been updated to include important new drugs such as gene therapies, personalised medicines and the new wave of RNA drugs. However it has not lost any of the elements that have contributed to its popularity, such as color coding and illustrations, making it reader-friendly while comprehensively covering the depth of detail required.This essential book is recommended as the first-choice undergraduate text for science and medical students and junior doctors and will also be useful for students in other professional disciplines such as pharmacy, veterinary medicine and nursing.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Video and Case Study Contents - p. xv 6. Inflammation case study - p. xv.ei 7. Cardiovascular case study - p. xv.eii 8. Respiratory case study - p. xv.eiii 9. Food and glucose regulation case study - p. xv.eiv 10. Neurodegenerative disease case study - p. xv.evi 11. Epilepsy case study - p. xv.eviii 12. Cancer case study - p. xv.eix 13. Videos Contents - p. xv.eix 14. Rang & Dale’s Pharmacology Tenth Edition Preface - p. xvi 15. Learning Resources - p. xvi 16. Assessments - p. xvi 17. Videos - p. xvi 18. Section 1. GENERAL PRINCIPLES - p. xvi 19. 1. What is pharmacology? - p. 1 20. 2. How drugs act: general principles - p. 6 21. 3. How drugs act: molecular aspects - p. 24 22. 4. How drugs act: cellular aspects – excitation, contraction and secretion - p. 54 23. 5. How drugs act: biopharmaceuticals and gene therapy - p. 72 24. 6. Cell proliferation, apoptosis, repair and regeneration - p. 87 25. 7. Cellular mechanisms: host defence - p. 98 26. 8. Method and measurement in pharmacology - p. 112 27. 9. Absorption and distribution of drugs - p. 123 28. 10. Drug metabolism and elimination - p. 140 29. 11. Pharmacokinetics - p. 150 30. 12. Individual variation, pharmacogenomics and personalised medicine - p. 160 31. Section 2. CHEMICAL MEDIATORS - p. 169.e2 32. 13. Chemical mediators and the autonomic nervous system - p. 170 33. 14. Cholinergic transmission - p. 182 34. 15. Noradrenergic transmission - p. 205 35. 16. 5-Hydroxytryptamine and the purines - p. 225 36. 17. Local hormones: histamine, lipids, peptides and proteins - p. 237 37. 18. Cannabinoids - p. 260 38. 19. Nitric oxide and related mediators - p. 267 39. Section 3. DRUGS AFFECTING MAJOR ORGAN SYSTEMS - p. 274.e2 40. 20. The heart - p. 275 41. 21. The vascular system - p. 294 42. 22. Atherosclerosis and lipoprotein metabolism - p. 313 43. 23. Haemostasis and thrombosis - p. 322 44. 24. Haematopoietic system and treatment of anaemia - p. 337 45. 25. Anti-inflammatory and immunosuppressant drugs - p. 350 46. 26. Skin - p. 371 47. 27. The eye - p. 384 48. 28. Respiratory system - p. 390 49. 29. The kidney and urinary system - p. 402 50. 30. The gastrointestinal tract - p. 416 51. 31. The control of blood glucose and drug treatment of diabetes mellitus - p. 429 52. 32. Obesity - p. 443 53. 33. The pituitary and the adrenal cortex - p. 452 54. 34. The thyroid - p. 469 55. 35. The reproductive system - p. 476 56. 36. Bone metabolism - p. 491 57. Section 4. NERVOUS SYSTEM - p. 500.e2 58. 37. Chemical transmission and drug action in the central nervous system - p. 501 59. 38. Amino acid transmitters - p. 509 60. 39. Other transmitters and modulators - p. 524 61. 40. Neurodegenerative diseases - p. 539 62. 41. General anaesthetic agents - p. 557 63. 42. Headache - p. 568 64. 43. Analgesic drugs - p. 575 65. 44. Local anaesthetics and other drugs affecting sodium channels - p. 595 66. 45. Anxiolytic and hypnotic drugs - p. 602 67. 46. Antiepileptic drugs - p. 613 68. 47. Antipsychotic drugs - p. 626 69. 48. Antidepressant drugs - p. 640 70. 49. Psychoactive drugs - p. 663 71. 50. Drug use and addiction - p. 683 72. Section 5. DRUGS USED FOR THE TREATMENT OF INFECTIONS AND CANCER - p. 689.e2 73. 51. Basic principles of antimicrobial chemotherapy - p. 690 74. 52. Antibacterial drugs - p. 704 75. 53. Antiviral drugs - p. 721 76. 54. Antifungal drugs - p. 736 77. 55. Antiprotozoal drugs - p. 742 78. 56. Antihelminthic drugs - p. 757 79. 57. Anticancer drugs - p. 764 80. Section 6. SPECIAL TOPICS - p. 782.e2 81. 58. Harmful effects of drugs - p. 783 82. 59. Lifestyle and drugs in sport - p. 794 83. 60. Drug discovery and development - p. 802 84. Index - p. 811.e2
Rang and Dale’s Pharmacology is internationally acknowledged as the core textbook for students of pharmacology, and has provided accessible, up-to-date information on drugs and their mechanism of action for more than 30 years.Now in its tenth edition, it has been updated to include important new drugs such as gene therapies, personalised medicines and the new wave of RNA drugs. However it has not lost any of the elements that have contributed to its popularity, such as color coding and illustrations, making it reader-friendly while comprehensively covering the depth of detail required.This essential book is recommended as the first-choice undergraduate text for science and medical students and junior doctors and will also be useful for students in other professional disciplines such as pharmacy, veterinary medicine and nursing.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Video and Case Study Contents - p. xv 6. Inflammation case study - p. xv.ei 7. Cardiovascular case study - p. xv.eii 8. Respiratory case study - p. xv.eiii 9. Food and glucose regulation case study - p. xv.eiv 10. Neurodegenerative disease case study - p. xv.evi 11. Epilepsy case study - p. xv.eviii 12. Cancer case study - p. xv.eix 13. Videos Contents - p. xv.eix 14. Rang & Dale’s Pharmacology Tenth Edition Preface - p. xvi 15. Learning Resources - p. xvi 16. Assessments - p. xvi 17. Videos - p. xvi 18. Section 1. GENERAL PRINCIPLES - p. xvi 19. 1. What is pharmacology? - p. 1 20. 2. How drugs act: general principles - p. 6 21. 3. How drugs act: molecular aspects - p. 24 22. 4. How drugs act: cellular aspects – excitation, contraction and secretion - p. 54 23. 5. How drugs act: biopharmaceuticals and gene therapy - p. 72 24. 6. Cell proliferation, apoptosis, repair and regeneration - p. 87 25. 7. Cellular mechanisms: host defence - p. 98 26. 8. Method and measurement in pharmacology - p. 112 27. 9. Absorption and distribution of drugs - p. 123 28. 10. Drug metabolism and elimination - p. 140 29. 11. Pharmacokinetics - p. 150 30. 12. Individual variation, pharmacogenomics and personalised medicine - p. 160 31. Section 2. CHEMICAL MEDIATORS - p. 169.e2 32. 13. Chemical mediators and the autonomic nervous system - p. 170 33. 14. Cholinergic transmission - p. 182 34. 15. Noradrenergic transmission - p. 205 35. 16. 5-Hydroxytryptamine and the purines - p. 225 36. 17. Local hormones: histamine, lipids, peptides and proteins - p. 237 37. 18. Cannabinoids - p. 260 38. 19. Nitric oxide and related mediators - p. 267 39. Section 3. DRUGS AFFECTING MAJOR ORGAN SYSTEMS - p. 274.e2 40. 20. The heart - p. 275 41. 21. The vascular system - p. 294 42. 22. Atherosclerosis and lipoprotein metabolism - p. 313 43. 23. Haemostasis and thrombosis - p. 322 44. 24. Haematopoietic system and treatment of anaemia - p. 337 45. 25. Anti-inflammatory and immunosuppressant drugs - p. 350 46. 26. Skin - p. 371 47. 27. The eye - p. 384 48. 28. Respiratory system - p. 390 49. 29. The kidney and urinary system - p. 402 50. 30. The gastrointestinal tract - p. 416 51. 31. The control of blood glucose and drug treatment of diabetes mellitus - p. 429 52. 32. Obesity - p. 443 53. 33. The pituitary and the adrenal cortex - p. 452 54. 34. The thyroid - p. 469 55. 35. The reproductive system - p. 476 56. 36. Bone metabolism - p. 491 57. Section 4. NERVOUS SYSTEM - p. 500.e2 58. 37. Chemical transmission and drug action in the central nervous system - p. 501 59. 38. Amino acid transmitters - p. 509 60. 39. Other transmitters and modulators - p. 524 61. 40. Neurodegenerative diseases - p. 539 62. 41. General anaesthetic agents - p. 557 63. 42. Headache - p. 568 64. 43. Analgesic drugs - p. 575 65. 44. Local anaesthetics and other drugs affecting sodium channels - p. 595 66. 45. Anxiolytic and hypnotic drugs - p. 602 67. 46. Antiepileptic drugs - p. 613 68. 47. Antipsychotic drugs - p. 626 69. 48. Antidepressant drugs - p. 640 70. 49. Psychoactive drugs - p. 663 71. 50. Drug use and addiction - p. 683 72. Section 5. DRUGS USED FOR THE TREATMENT OF INFECTIONS AND CANCER - p. 689.e2 73. 51. Basic principles of antimicrobial chemotherapy - p. 690 74. 52. Antibacterial drugs - p. 704 75. 53. Antiviral drugs - p. 721 76. 54. Antifungal drugs - p. 736 77. 55. Antiprotozoal drugs - p. 742 78. 56. Antihelminthic drugs - p. 757 79. 57. Anticancer drugs - p. 764 80. Section 6. SPECIAL TOPICS - p. 782.e2 81. 58. Harmful effects of drugs - p. 783 82. 59. Lifestyle and drugs in sport - p. 794 83. 60. Drug discovery and development - p. 802 84. Index - p. 811.e2
