Recent Trends in Carbohydrate Chemistry: Synthesis and Biomedical Applications of Glycans and Glycoconjugates covers biomedically relevant bacterial cell wall carbohydrates including recent findings on biosynthetic aspects, advances in the chemical assembly of bacterial lipopolysaccharide fragments and teichoic acids, and modern NMR approaches to unravel structural details. The first part introduces and provides the relevant background for synthetic glycoconjugate vaccines. The second section focuses on synthetic carbohydrate-based vaccines of therapeutic potential that are licensed or under development.
This second volume of Recent Trends in Carbohydrate Chemistry is ideal for researchers working as synthetic organic chemists, as well as those interested in glycoconjugation, protein chemists, immunologists, and microbiologists, in academia as well as in industry.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_ix 6. Preface - p. page_xi 7. Part One: Advances in chemical synthesis and biosynthesis of bacterial glycans - p. page_xi 8. 1: Prokaryotes: Sweet proteins do matter - p. page_xi 9. 2: Glycan ligation reactions in the periplasmic space - p. page_36 10. 3: Synthesis of bioactive lipid A and analogs - p. page_49 11. 4: Synthesis of lipopolysaccharide core fragments - p. page_102 12. 5: Synthesis of oligosaccharides related to potential bioterrorist pathogens - p. page_140 13. 6: Synthetic teichoic acid chemistry for vaccine applications - p. page_206 14. 7: NMR characterization of bacterial glycans and glycoconjugate vaccines - p. page_238 15. Part Two: Synthetic carbohydrate-based vaccines: present and future - p. page_281 16. 8: Glycoconjugate vaccines, production and characterization - p. page_281 17. 9: Antifungal glycoconjugate vaccines - p. page_313 18. 10: Site-selective conjugation chemistry for synthetic glycoconjugate vaccine development - p. page_334 19. 11: Glyconanoparticles as versatile platforms for vaccine development: A minireview - p. page_380 20. Index - p. page_413
Recent Trends in Carbohydrate Chemistry: Synthesis and Biomedical Applications of Glycans and Glycoconjugates covers biomedically relevant bacterial cell wall carbohydrates including recent findings on biosynthetic aspects, advances in the chemical assembly of bacterial lipopolysaccharide fragments and teichoic acids, and modern NMR approaches to unravel structural details. The first part introduces and provides the relevant background for synthetic glycoconjugate vaccines. The second section focuses on synthetic carbohydrate-based vaccines of therapeutic potential that are licensed or under development.
This second volume of Recent Trends in Carbohydrate Chemistry is ideal for researchers working as synthetic organic chemists, as well as those interested in glycoconjugation, protein chemists, immunologists, and microbiologists, in academia as well as in industry.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_ix 6. Preface - p. page_xi 7. Part One: Advances in chemical synthesis and biosynthesis of bacterial glycans - p. page_xi 8. 1: Prokaryotes: Sweet proteins do matter - p. page_xi 9. 2: Glycan ligation reactions in the periplasmic space - p. page_36 10. 3: Synthesis of bioactive lipid A and analogs - p. page_49 11. 4: Synthesis of lipopolysaccharide core fragments - p. page_102 12. 5: Synthesis of oligosaccharides related to potential bioterrorist pathogens - p. page_140 13. 6: Synthetic teichoic acid chemistry for vaccine applications - p. page_206 14. 7: NMR characterization of bacterial glycans and glycoconjugate vaccines - p. page_238 15. Part Two: Synthetic carbohydrate-based vaccines: present and future - p. page_281 16. 8: Glycoconjugate vaccines, production and characterization - p. page_281 17. 9: Antifungal glycoconjugate vaccines - p. page_313 18. 10: Site-selective conjugation chemistry for synthetic glycoconjugate vaccine development - p. page_334 19. 11: Glyconanoparticles as versatile platforms for vaccine development: A minireview - p. page_380 20. Index - p. page_413
