Receptors in the Evolution and Development of the Brain: Matter into Mind presents the key role of receptors and their cognate ligands in wiring the mammalian brain from an evolutionary developmental biology perspective. It examines receptor function in the evolution and development of the nervous system in the large vertebrate brain, and discusses rapid eye movement sleep and apoptosis as mechanisms to destroy miswired neurons. Possible links between trophic deficits and connectional diseases including Alzheimer’s, Parkinson’s, and ALS are also discussed. This book is extremely useful to those with an interest in the molecular and cellular neurosciences, including those in cognitive and clinical branches of this subject, and anyone interested in how the incredibly complex human brain can build itself.
1. Introduction - p. xi 2. Chapter 1. Classes of receptors, their signaling pathways, and their synthesis and transport - p. 1 3. Chapter 2. The RNA world: receptors and their cognate ligands in Archaea, Bacteria, and Choanoflagellates - p. 35 4. Chapter 3. Dictyostelium discoideum, sponges, comb jellies, and hydra: the earliest animals - p. 45 5. Chapter 4. The growth cone and the synapse - p. 51 6. Chapter 5. Neuronal cell biology - p. 71 7. Chapter 6. Glial cells, the myelinated axon, and the blood-brain barrier - p. 77 8. Chapter 7. A testable theory on the wiring of the brain - p. 95 9. Chapter 8. Development of the cerebral cortex - p. 101 10. Chapter 9. The importance of sleep in selecting neuronal circuitry; programmed cell death/apoptosis - p. 117 11. Chapter 10. BDNF and endocannabinoids in brain development: neuronal commitment, migration, and synaptogenesis - p. 133 12. Chapter 11. Axon and dendrite guidance molecules and the extracellular matrix in brain development - p. 149 13. Chapter 12. Key receptors involved in laminar and terminal specification and synapse construction - p. 163 14. Chapter 13. Steroid hormones, glucocorticoids, and the hypothalamus - p. 173 15. Chapter 14. Receptors and the development of the enteric nervous system - p. 183 16. Chapter 15. Synaptic pruning and trophic factor interactions during development - p. 193 17. Chapter 16. Receptor-mediated mechanisms for drugs of abuse and brain development - p. 199 18. Chapter 17. Role of trophic factors and receptors in developmental disorders - p. 209 19. Chapter 18. Neuronal survival and connectional neurodegenerative diseases - p. 217 20. Chapter 19. Neuronal stem cells - p. 237 21. Chapter 20. Summary and conclusions - p. 245 22. Index - p. 263
Receptors in the Evolution and Development of the Brain: Matter into Mind presents the key role of receptors and their cognate ligands in wiring the mammalian brain from an evolutionary developmental biology perspective. It examines receptor function in the evolution and development of the nervous system in the large vertebrate brain, and discusses rapid eye movement sleep and apoptosis as mechanisms to destroy miswired neurons. Possible links between trophic deficits and connectional diseases including Alzheimer’s, Parkinson’s, and ALS are also discussed. This book is extremely useful to those with an interest in the molecular and cellular neurosciences, including those in cognitive and clinical branches of this subject, and anyone interested in how the incredibly complex human brain can build itself.
1. Introduction - p. xi 2. Chapter 1. Classes of receptors, their signaling pathways, and their synthesis and transport - p. 1 3. Chapter 2. The RNA world: receptors and their cognate ligands in Archaea, Bacteria, and Choanoflagellates - p. 35 4. Chapter 3. Dictyostelium discoideum, sponges, comb jellies, and hydra: the earliest animals - p. 45 5. Chapter 4. The growth cone and the synapse - p. 51 6. Chapter 5. Neuronal cell biology - p. 71 7. Chapter 6. Glial cells, the myelinated axon, and the blood-brain barrier - p. 77 8. Chapter 7. A testable theory on the wiring of the brain - p. 95 9. Chapter 8. Development of the cerebral cortex - p. 101 10. Chapter 9. The importance of sleep in selecting neuronal circuitry; programmed cell death/apoptosis - p. 117 11. Chapter 10. BDNF and endocannabinoids in brain development: neuronal commitment, migration, and synaptogenesis - p. 133 12. Chapter 11. Axon and dendrite guidance molecules and the extracellular matrix in brain development - p. 149 13. Chapter 12. Key receptors involved in laminar and terminal specification and synapse construction - p. 163 14. Chapter 13. Steroid hormones, glucocorticoids, and the hypothalamus - p. 173 15. Chapter 14. Receptors and the development of the enteric nervous system - p. 183 16. Chapter 15. Synaptic pruning and trophic factor interactions during development - p. 193 17. Chapter 16. Receptor-mediated mechanisms for drugs of abuse and brain development - p. 199 18. Chapter 17. Role of trophic factors and receptors in developmental disorders - p. 209 19. Chapter 18. Neuronal survival and connectional neurodegenerative diseases - p. 217 20. Chapter 19. Neuronal stem cells - p. 237 21. Chapter 20. Summary and conclusions - p. 245 22. Index - p. 263
