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In consultation with Consulting Editor Dr. William Rayburn, Dr. Santor and Dr. Kravitz have put together an issue that comprehensively covers age-related changes in women. Their authors, from well-respected institutions, have contributed review articles on the following topics: Declining fertility with reproductive aging: How to protect your patient’s fertility by knowing the milestones; Onset of the transition into menopause: What are the earliest signs; Menstrual cycle changes as women approach the final menses: What matters; Menstrual cycle hormone changes and how they may link to symptoms; Symptom progression across the transition: Not all women are created equal; Cardiovascular implications of vasomotor symptoms and the menopausal transition; Depression and perimenopause :Hormones, genetics and environmental determinants of disease; Sleep, health, and metabolism: Food for thought; Bone health during the menopausal transition and beyond; Sexuality in midlife and beyond; Physical function –moving and aging; Genitourinary changes with aging; and Cognitive changes with reproductive aging, perimenopause, and menopause. Readers will come away with the latest clinical information they need to treat these patients and improve outcomes.

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Foreword - p. xiii 8. Preface - p. xv 9. Declining Fertility with Reproductive Aging: How to Protect Your Patient’s Fertility by Knowing the Milestones - p. 575 10. Onset of the Menopause Transition: The Earliest Signs and Symptoms - p. 585 11. Menstrual Cycle Changes as Women Approach the Final Menses: What Matters? - p. 599 12. Menstrual Cycle Hormone Changes Associated with Reproductive Aging and How They May Relate to Symptoms - p. 613 13. Vasomotor Symptoms Across the Menopause Transition: Differences Among Women - p. 629 14. Cardiovascular Implications of the Menopause Transition: Endogenous Sex Hormones and Vasomotor Symptoms - p. 641 15. Depression During and After the Perimenopause: Impact of Hormones, Genetics, and Environmental Determinants of Disease - p. 663 16. Sleep, Health, and Metabolism in Midlife Women and Menopause: Food for Thought - p. 679 17. Bone Health During the Menopause Transition and Beyond - p. 695 18. Female Sexual Function at Midlife and Beyond - p. 709 19. Physical Activity and Physical Function: Moving and Aging - p. 723 20. Genitourinary Changes with Aging - p. 737 21. Cognitive Changes with Reproductive Aging, Perimenopause, and Menopause - p. 751

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In consultation with Consulting Editor Dr. William Rayburn, Dr. Santor and Dr. Kravitz have put together an issue that comprehensively covers age-related changes in women. Their authors, from well-respected institutions, have contributed review articles on the following topics: Declining fertility with reproductive aging: How to protect your patient’s fertility by knowing the milestones; Onset of the transition into menopause: What are the earliest signs; Menstrual cycle changes as women approach the final menses: What matters; Menstrual cycle hormone changes and how they may link to symptoms; Symptom progression across the transition: Not all women are created equal; Cardiovascular implications of vasomotor symptoms and the menopausal transition; Depression and perimenopause :Hormones, genetics and environmental determinants of disease; Sleep, health, and metabolism: Food for thought; Bone health during the menopausal transition and beyond; Sexuality in midlife and beyond; Physical function –moving and aging; Genitourinary changes with aging; and Cognitive changes with reproductive aging, perimenopause, and menopause. Readers will come away with the latest clinical information they need to treat these patients and improve outcomes.

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Foreword - p. xiii 8. Preface - p. xv 9. Declining Fertility with Reproductive Aging: How to Protect Your Patient’s Fertility by Knowing the Milestones - p. 575 10. Onset of the Menopause Transition: The Earliest Signs and Symptoms - p. 585 11. Menstrual Cycle Changes as Women Approach the Final Menses: What Matters? - p. 599 12. Menstrual Cycle Hormone Changes Associated with Reproductive Aging and How They May Relate to Symptoms - p. 613 13. Vasomotor Symptoms Across the Menopause Transition: Differences Among Women - p. 629 14. Cardiovascular Implications of the Menopause Transition: Endogenous Sex Hormones and Vasomotor Symptoms - p. 641 15. Depression During and After the Perimenopause: Impact of Hormones, Genetics, and Environmental Determinants of Disease - p. 663 16. Sleep, Health, and Metabolism in Midlife Women and Menopause: Food for Thought - p. 679 17. Bone Health During the Menopause Transition and Beyond - p. 695 18. Female Sexual Function at Midlife and Beyond - p. 709 19. Physical Activity and Physical Function: Moving and Aging - p. 723 20. Genitourinary Changes with Aging - p. 737 21. Cognitive Changes with Reproductive Aging, Perimenopause, and Menopause - p. 751

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