**Selected for Doody’s Core Titles® 2024 in Toxicology**
Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlife
With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies.
1. Introduction - p. Page x 2. List of Illustrations - p. Page xiii 3. List of Tables - p. Page xiv 4. Chapter 1 : Reproductive anatomy and physiology - p. Page xiv 5. Chapter 2 : Pharmacokinetics in pregnancy - p. Page 31 6. Chapter 3 : Physiologically based pharmacokinetic models in reproductive and developmental toxicology - p. Page 43 7. Chapter 4 : Adverse Outcome Pathways in reproductive and developmental toxicology - p. Page 59 8. Chapter 5 : Juvenile toxicology testing - p. Page 71 9. Chapter 6 : Relevance of animal testing and sensitivity of end points in reproductive and developmental toxicity - p. Page 90 10. Chapter 7 : Alternative methods to animal experimentation for testing developmental toxicity - p. Page 102 11. Chapter 8 : Use of computational toxicology tools to predict in vivo endpoints - p. Page 122 12. Chapter 9 : Guidelines for reproductive and developmental toxicity testing and risk assessment of chemicals - p. Page 144 13. Chapter 10 : Reproductive toxicity: in vivo testing guidelines from OECD - p. Page 160 14. Chapter 11 : In vitro biomarkers of developmental neurotoxicity - p. Page 178 15. Chapter 12 : Reproductive and developmental safety evaluation of new pharmaceutical compounds - p. Page 200 16. Chapter 13 : Using zebrafish to assess developmental neurotoxicity - p. Page 233 17. Chapter 14 : Caenorhabditis elegans as a model to assess reproductive and developmental toxicity - p. Page 249 18. Chapter 15 : Postmarket surveillance and regulatory considerations in reproductive and developmental toxicology: a Food and Drug Administration perspective - p. Page 262 19. Chapter 16 : Developmental toxicity of engineered nanomaterials - p. Page 280 20. Chapter 17 : Effects of ionizing radiation on reproduction and development - p. Page 302 21. Chapter 18 : Reproductive and developmental toxicity of solvents and gases - p. Page 334 22. Chapter 19 : Developmental neurotoxicity of drugs of abuse - p. Page 351 23. Chapter 20 : Effects of alcohol on embryo/fetal development - p. Page 373 24. Chapter 21 : Cigarette and E-cigarettes smoking and reproductive and developmental toxicity - p. Page 391 25. Chapter 22 : Thalidomide - p. Page 417 26. Chapter 23 : Retinoids - p. Page 434 27. Chapter 24 : Safety of cannabis- and hemp-derived constituents in reproduction and development - p. Page 449 28. Chapter 25 : Caffeine - p. Page 478 29. Chapter 26 : Melamine and cyanuric acid - p. Page 498 30. Chapter 27 : Ionophores - p. Page 510 31. Chapter 28 : Boron - p. Page 525 32. Chapter 29 : Arsenic, cadmium, and lead - p. Page 543 33. Chapter 30 : Mercury - p. Page 568 34. Chapter 31 : Manganese - p. Page 581 35. Chapter 32 : Selenium - p. Page 597 36. Chapter 33 : Organophosphates and carbamates - p. Page 610 37. Chapter 34 : Chlorinated hydrocarbons and pyrethrins/pyrethroids - p. Page 633 38. Chapter 35 : Herbicides and fungicides - p. Page 660 39. Chapter 36 : Brominated flame retardants - p. Page 684 40. Chapter 37 : Polychlorinated biphenyls, polybrominated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans - p. Page 717 41. Chapter 38 : Reproductive toxicity of polycyclic aromatic hydrocarbons - p. Page 751 42. Chapter 39 : Bisphenol A—toxicity and risk assessment update with academic and regulatory perspectives and physiologically based pharmacokinetic modeling - p. Page 774 43. Chapter 40 : Ethylene glycol - p. Page 799 44. Chapter 41 : Perfluorooctane sulfonate and perfluorooctanoic acid - p. Page 813 45. Chapter 42 : Traffic-related air pollution and the developing brain - p. Page 826 46. Chapter 43 : Environmental pollutants and embryonic implantation and embryonic development - p. Page 839 47. Chapter 44 : Personal care products and cosmetics - p. Page 863 48. Chapter 45 : UV screening chemicals - p. Page 898 49. Chapter 46 : Toxic plants - p. Page 927 50. Chapter 47 : Fumonisins - p. Page 950 51. Chapter 48 : Aflatoxins, ochratoxins, and citrinin - p. Page 975 52. Chapter 49 : Trichothecenes and zearalenone - p. Page 996 53. Chapter 50 : Drugs and chemical contaminants in human breast milk - p. Page 1013 54. Chapter 51 : Stem cells in developmental toxicity testing - p. Page 1048 55. Chapter 52 : Embryonic and fetal toxic lesions and stem cell therapy - p. Page 1067 56. Chapter 53 : Epigenetics in reproduction and development - p. Page 1087 57. Chapter 54 : Mitochondrial dysfunction in reproductive and developmental toxicity - p. Page 1101 58. Chapter 55 : Cell signaling mechanisms in developmental neurotoxicity - p. Page 1112 59. Chapter 56 : Neuroinflammation and oxidative injury in developmental neurotoxicity - p. Page 1125 60. Chapter 57 : Effects of stress on reproductive function and fetal development - p. Page 1137 61. Chapter 58 : Endocrine disruption - p. Page 1154 62. Chapter 59 : Role of endocrine disruptors in male infertility and impact of COVID-19 on male reproduction - p. Page 1180 63. Chapter 60 : Toxicology of reproduction process and problems of male infertility - p. Page 1191 64. Chapter 61 : Environmental pollutants and neural tube defects - p. Page 1215 65. Chapter 62 : Teratogenicity - p. Page 1240 66. Chapter 63 : Micro-CT and volumetric imaging in developmental toxicology - p. Page 1256 67. Chapter 64 : Toxicologic pathology of the reproductive system - p. Page 1283 68. Chapter 65 : The placental role in developmental programming - p. Page 1315 69. Chapter 66 : Strategies for investigating hemochorial placentation - p. Page 1335 70. Chapter 67 : The significance of ABC transporters in human placenta for the exposure of fetus to xenobiotics - p. Page 1351 71. Chapter 68 : Placental toxicity - p. Page 1367 72. Chapter 69 : Placental pathology - p. Page 1391 73. Chapter 70 : Endocrine disruption in wildlife species - p. Page 1416 74. Chapter 71 : Teratogenesis in livestock - p. Page 1437 75. Chapter 72 : Reproductive and developmental toxicity in avian species - p. Page 1456 76. Index - p. Page 1479
**Selected for Doody’s Core Titles® 2024 in Toxicology**
Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlife
With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies.
1. Introduction - p. Page x 2. List of Illustrations - p. Page xiii 3. List of Tables - p. Page xiv 4. Chapter 1 : Reproductive anatomy and physiology - p. Page xiv 5. Chapter 2 : Pharmacokinetics in pregnancy - p. Page 31 6. Chapter 3 : Physiologically based pharmacokinetic models in reproductive and developmental toxicology - p. Page 43 7. Chapter 4 : Adverse Outcome Pathways in reproductive and developmental toxicology - p. Page 59 8. Chapter 5 : Juvenile toxicology testing - p. Page 71 9. Chapter 6 : Relevance of animal testing and sensitivity of end points in reproductive and developmental toxicity - p. Page 90 10. Chapter 7 : Alternative methods to animal experimentation for testing developmental toxicity - p. Page 102 11. Chapter 8 : Use of computational toxicology tools to predict in vivo endpoints - p. Page 122 12. Chapter 9 : Guidelines for reproductive and developmental toxicity testing and risk assessment of chemicals - p. Page 144 13. Chapter 10 : Reproductive toxicity: in vivo testing guidelines from OECD - p. Page 160 14. Chapter 11 : In vitro biomarkers of developmental neurotoxicity - p. Page 178 15. Chapter 12 : Reproductive and developmental safety evaluation of new pharmaceutical compounds - p. Page 200 16. Chapter 13 : Using zebrafish to assess developmental neurotoxicity - p. Page 233 17. Chapter 14 : Caenorhabditis elegans as a model to assess reproductive and developmental toxicity - p. Page 249 18. Chapter 15 : Postmarket surveillance and regulatory considerations in reproductive and developmental toxicology: a Food and Drug Administration perspective - p. Page 262 19. Chapter 16 : Developmental toxicity of engineered nanomaterials - p. Page 280 20. Chapter 17 : Effects of ionizing radiation on reproduction and development - p. Page 302 21. Chapter 18 : Reproductive and developmental toxicity of solvents and gases - p. Page 334 22. Chapter 19 : Developmental neurotoxicity of drugs of abuse - p. Page 351 23. Chapter 20 : Effects of alcohol on embryo/fetal development - p. Page 373 24. Chapter 21 : Cigarette and E-cigarettes smoking and reproductive and developmental toxicity - p. Page 391 25. Chapter 22 : Thalidomide - p. Page 417 26. Chapter 23 : Retinoids - p. Page 434 27. Chapter 24 : Safety of cannabis- and hemp-derived constituents in reproduction and development - p. Page 449 28. Chapter 25 : Caffeine - p. Page 478 29. Chapter 26 : Melamine and cyanuric acid - p. Page 498 30. Chapter 27 : Ionophores - p. Page 510 31. Chapter 28 : Boron - p. Page 525 32. Chapter 29 : Arsenic, cadmium, and lead - p. Page 543 33. Chapter 30 : Mercury - p. Page 568 34. Chapter 31 : Manganese - p. Page 581 35. Chapter 32 : Selenium - p. Page 597 36. Chapter 33 : Organophosphates and carbamates - p. Page 610 37. Chapter 34 : Chlorinated hydrocarbons and pyrethrins/pyrethroids - p. Page 633 38. Chapter 35 : Herbicides and fungicides - p. Page 660 39. Chapter 36 : Brominated flame retardants - p. Page 684 40. Chapter 37 : Polychlorinated biphenyls, polybrominated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans - p. Page 717 41. Chapter 38 : Reproductive toxicity of polycyclic aromatic hydrocarbons - p. Page 751 42. Chapter 39 : Bisphenol A—toxicity and risk assessment update with academic and regulatory perspectives and physiologically based pharmacokinetic modeling - p. Page 774 43. Chapter 40 : Ethylene glycol - p. Page 799 44. Chapter 41 : Perfluorooctane sulfonate and perfluorooctanoic acid - p. Page 813 45. Chapter 42 : Traffic-related air pollution and the developing brain - p. Page 826 46. Chapter 43 : Environmental pollutants and embryonic implantation and embryonic development - p. Page 839 47. Chapter 44 : Personal care products and cosmetics - p. Page 863 48. Chapter 45 : UV screening chemicals - p. Page 898 49. Chapter 46 : Toxic plants - p. Page 927 50. Chapter 47 : Fumonisins - p. Page 950 51. Chapter 48 : Aflatoxins, ochratoxins, and citrinin - p. Page 975 52. Chapter 49 : Trichothecenes and zearalenone - p. Page 996 53. Chapter 50 : Drugs and chemical contaminants in human breast milk - p. Page 1013 54. Chapter 51 : Stem cells in developmental toxicity testing - p. Page 1048 55. Chapter 52 : Embryonic and fetal toxic lesions and stem cell therapy - p. Page 1067 56. Chapter 53 : Epigenetics in reproduction and development - p. Page 1087 57. Chapter 54 : Mitochondrial dysfunction in reproductive and developmental toxicity - p. Page 1101 58. Chapter 55 : Cell signaling mechanisms in developmental neurotoxicity - p. Page 1112 59. Chapter 56 : Neuroinflammation and oxidative injury in developmental neurotoxicity - p. Page 1125 60. Chapter 57 : Effects of stress on reproductive function and fetal development - p. Page 1137 61. Chapter 58 : Endocrine disruption - p. Page 1154 62. Chapter 59 : Role of endocrine disruptors in male infertility and impact of COVID-19 on male reproduction - p. Page 1180 63. Chapter 60 : Toxicology of reproduction process and problems of male infertility - p. Page 1191 64. Chapter 61 : Environmental pollutants and neural tube defects - p. Page 1215 65. Chapter 62 : Teratogenicity - p. Page 1240 66. Chapter 63 : Micro-CT and volumetric imaging in developmental toxicology - p. Page 1256 67. Chapter 64 : Toxicologic pathology of the reproductive system - p. Page 1283 68. Chapter 65 : The placental role in developmental programming - p. Page 1315 69. Chapter 66 : Strategies for investigating hemochorial placentation - p. Page 1335 70. Chapter 67 : The significance of ABC transporters in human placenta for the exposure of fetus to xenobiotics - p. Page 1351 71. Chapter 68 : Placental toxicity - p. Page 1367 72. Chapter 69 : Placental pathology - p. Page 1391 73. Chapter 70 : Endocrine disruption in wildlife species - p. Page 1416 74. Chapter 71 : Teratogenesis in livestock - p. Page 1437 75. Chapter 72 : Reproductive and developmental toxicity in avian species - p. Page 1456 76. Index - p. Page 1479
