For more than 30 years, the highly regarded Secrets Series® has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Rheumatology Secrets, 5th Edition, offers practical, up-to-date coverage of the full range of essential topics in this dynamic field. This highly regarded resource features the Secrets’ popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style—making inquiry, reference, and review quick, easy, and enjoyable.
1. Cover image - p. c 2. Volumes in the Secrets Series - p. ii 3. Title page - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. Contributors - p. vi 7. Preface - p. xiii 8. Acknowledgments - p. xiv 9. Contents - p. xv 10. SECTION I General Concepts - p. p1 11. Chapter 1 Top 100+ Rheumatology Secrets - p. 1 12. Chapter 2 Classification and Health Impact of the Rheumatic Diseases - p. 16 13. Chapter 3 Anatomy and Physiology of the Musculoskeletal System - p. 21 14. Chapter 4 An Overview of the Immune Response, Inflammation, and Autoimmunity - p. 32 15. SECTION II Evaluation of the Patient With Rheumatic Symptoms - p. p51 16. Chapter 5 History and Physical Examination - p. 51 17. Chapter 6 Laboratory Evaluation - p. 61 18. Chapter 7 Arthrocentesis, Synovial Fluid Analysis, and Synovial Biopsy - p. 75 19. Chapter 8 Radiographic and Imaging Modalities - p. 82 20. Chapter 9 Electromyography and Nerve Conduction Studies - p. 98 21. Chapter 10 Approach for Patients With Monoarticular Arthritis Symptoms - p. 104 22. Chapter 11 Approach for Patients With Polyarticular Arthritis Symptoms - p. 110 23. Chapter 12 Approach to the Patient With Neuromuscular Symptoms - p. 117 24. Chapter 13 Perioperative Management of Patients With Rheumatic Diseases - p. 125 25. SECTION III Systemic Connective Tissue Diseases - p. p138 26. Chapter 14 Rheumatoid Arthritis - p. 138 27. Chapter 15 Systemic Lupus Erythematosus - p. 154 28. Chapter 16 Drug-induced Lupus Erythematosus - p. 178 29. Chapter 17 Systemic Sclerosis - p. 184 30. Chapter 18 Scleroderma Mimics - p. 203 31. Chapter 19 Idiopathic Inflammatory Myopathies - p. 210 32. Chapter 20 Mixed Connective Tissue Disease, Overlap Syndromes, and Undifferentiated Connective Tissue Disease - p. 221 33. Chapter 21 Sjögren Disease - p. 228 34. Chapter 22 Antiphospholipid Syndrome - p. 239 35. Chapter 23 Adult-Onset Still’s Disease - p. 251 36. Chapter 24 Polymyalgia Rheumatica - p. 257 37. SECTION IV The Vasculitides and Related Disorders - p. p264 38. Chapter 25 Approach for Patients With Suspected Vasculitis - p. 264 39. Chapter 26 Large-Vessel Vasculitis: Giant Cell Arteritis, Takayasu Arteritis, and Aortitis - p. 273 40. Chapter 27 Polyarteritis Nodosa, Thromboangiitis Obliterans, and Primary Central Nervous System Vasculitis - p. 285 41. Chapter 28 Antineutrophil Cytoplasmic Antibody-Associated Vasculitis - p. 297 42. Chapter 29 Immune Complex-Mediated Small-Vessel Vasculitides - p. 315 43. Chapter 30 Cryoglobulinemia - p. 324 44. Chapter 31 Behçet Syndrome - p. 333 45. Chapter 32 Relapsing Polychondritis - p. 340 46. SECTION V Seronegative Spondyloarthropathies - p. p349 47. Chapter 33 Axial Spondyloarthritis - p. 349 48. Chapter 34 Rheumatic Manifestations of Gastrointestinal and Hepatobiliary Diseases - p. 358 49. Chapter 35 Reactive Arthritis - p. 367 50. Chapter 36 Arthritis Associated With Psoriasis and Other Skin Diseases - p. 378 51. SECTION VI Arthritis Associated With Infectious Agents - p. p387 52. Chapter 37 Bacterial Septic Arthritis, Bursitis, and Osteomyelitis - p. 387 53. Chapter 38 Lyme Disease - p. 397 54. Chapter 39 Mycobacterial and Fungal Joint and Bone Diseases - p. 406 55. Chapter 40 Viral Arthritides - p. 415 56. Chapter 41 HIV-Associated Rheumatic Syndromes - p. 424 57. Chapter 42 Whipple Disease - p. 432 58. Chapter 43 Acute Rheumatic Fever and Poststreptococcal Arthritis - p. 438 59. SECTION VII Rheumatic Disorders Associated With Metabolic, Endocrine, and Hematologic Diseases - p. p445 60. Chapter 44 Gout - p. 445 61. Chapter 45 Calcium Pyrophosphate Deposition Disease - p. 456 62. Chapter 46 Basic Calcium Phosphate and Other Crystalline Diseases - p. 464 63. Chapter 47 Endocrine-Associated Arthropathies - p. 471 64. Chapter 48 Arthropathies Associated With Hematologic Diseases - p. 481 65. Chapter 49 Malignancy-Associated Rheumatic Disorders - p. 489 66. SECTION VIII Bone and Cartilage Disorders - p. p498 67. Chapter 50 Osteoarthritis - p. 498 68. Chapter 51 Metabolic Bone Disease - p. 510 69. Chapter 52 Paget Disease of Bone - p. 521 70. Chapter 53 Osteonecrosis - p. 527 71. SECTION IX Hereditary, Congenital, and Inborn Errors of Metabolism Associated With Rheumatic Syndromes - p. p534 72. Chapter 54 Heritable Connective Tissue Diseases - p. 534 73. Chapter 55 Inborn Errors of Metabolism Affecting Connective Tissue - p. 543 74. Chapter 56 Storage and Deposition Diseases - p. 550 75. Chapter 57 Rheumatologic Manifestations of the Primary Immunodeficiency Syndromes - p. 556 76. Chapter 58 Skeletal Dysplasias - p. 565 77. SECTION X Nonarticular and Regional Musculoskeletal Disorders - p. p537 78. Chapter 59 Approach for the Patient With Neck and Low Back Pain - p. 573 79. Chapter 60 Fibromyalgia - p. 583 80. Chapter 61 Regional Musculoskeletal Disorders - p. 595 81. Chapter 62 Sports Medicine and Occupational Injuries - p. 605 82. Chapter 63 Entrapment Neuropathies - p. 613 83. Chapter 64 Complex Regional Pain Syndrome - p. 623 84. SECTION XI Neoplasms and Tumor-like Lesions - p. p633 85. Chapter 65 Benign and Malignant Tumors of Joints and Synovium - p. 633 86. Chapter 66 Common Bony Lesions: Radiographic Features - p. 638 87. SECTION XII Pediatric Rheumatic Diseases - p. p657 88. Chapter 67 Approach to the Child With Joint Pain - p. 657 89. Chapter 68 Juvenile Idiopathic Arthritis - p. 666 90. Chapter 69 Juvenile Systemic Connective Tissue Diseases and Vasculitides - p. 675 91. Chapter 70 Kawasaki Disease - p. 685 92. SECTION XIII Miscellaneous Rheumatic Disorders - p. p701 93. Chapter 71 Genetic Muscle Diseases: Metabolic and Other Genetic Muscle Disorders - p. 690 94. Chapter 72 Amyloidosis - p. 701 95. Chapter 73 Raynaud’s Phenomenon - p. 710 96. Chapter 74 Autoimmune Eye and Ear Disorders - p. 719 97. Chapter 75 Rheumatic Syndromes Associated With Sarcoidosis - p. 735 98. Chapter 76 IgG4-Related Disease - p. 746 99. Chapter 77 Rheumatic Disorders in Patients on Dialysis - p. 754 100. Chapter 78 Rheumatic Disease and the Pregnant Patient - p. 762 101. Chapter 79 Autoinflammatory Syndromes - p. 774 102. Chapter 80 Odds and Ends - p. 788 103. SECTION XIV Management of the Rheumatic Diseases - p. p802 104. Chapter 81 Nonsteroidal Anti-Inflammatory Drugs - p. 802 105. Chapter 82 Glucocorticoids—Systemic and Injectable - p. 808 106. Chapter 83 DMARDs: csDMARDs and tsDMARDs - p. 818 107. Chapter 84 Disease Modifying Anti-Rheumatic Drugs: Biologic Agents - p. 831 108. Chapter 85 Immunosuppressive and Immunoregulatory Agents - p. 849 109. Chapter 86 Hypouricemic Agents and Colchicine - p. 859 110. Chapter 87 Bone Strengthening Agents - p. 867 111. Chapter 88 Rehabilitative Techniques - p. 881 112. Chapter 89 Surgical Treatment and Rheumatic Diseases - p. 891 113. Chapter 90 Disability - p. 903 114. SECTION XV Final Secrets - p. p910 115. Chapter 91 Complementary and Alternative Medicine - p. 910 116. Chapter 92 History, the Arts, and Rheumatic Diseases - p. 920 117. SECTION XVI eAppendix Board-Style Questions - p. p926 118. Rheumatology Secrets Electronic Online Question Bank - p. page_1.e1 119. Index - p. 926
For more than 30 years, the highly regarded Secrets Series® has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Rheumatology Secrets, 5th Edition, offers practical, up-to-date coverage of the full range of essential topics in this dynamic field. This highly regarded resource features the Secrets’ popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style—making inquiry, reference, and review quick, easy, and enjoyable.
1. Cover image - p. c 2. Volumes in the Secrets Series - p. ii 3. Title page - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. Contributors - p. vi 7. Preface - p. xiii 8. Acknowledgments - p. xiv 9. Contents - p. xv 10. SECTION I General Concepts - p. p1 11. Chapter 1 Top 100+ Rheumatology Secrets - p. 1 12. Chapter 2 Classification and Health Impact of the Rheumatic Diseases - p. 16 13. Chapter 3 Anatomy and Physiology of the Musculoskeletal System - p. 21 14. Chapter 4 An Overview of the Immune Response, Inflammation, and Autoimmunity - p. 32 15. SECTION II Evaluation of the Patient With Rheumatic Symptoms - p. p51 16. Chapter 5 History and Physical Examination - p. 51 17. Chapter 6 Laboratory Evaluation - p. 61 18. Chapter 7 Arthrocentesis, Synovial Fluid Analysis, and Synovial Biopsy - p. 75 19. Chapter 8 Radiographic and Imaging Modalities - p. 82 20. Chapter 9 Electromyography and Nerve Conduction Studies - p. 98 21. Chapter 10 Approach for Patients With Monoarticular Arthritis Symptoms - p. 104 22. Chapter 11 Approach for Patients With Polyarticular Arthritis Symptoms - p. 110 23. Chapter 12 Approach to the Patient With Neuromuscular Symptoms - p. 117 24. Chapter 13 Perioperative Management of Patients With Rheumatic Diseases - p. 125 25. SECTION III Systemic Connective Tissue Diseases - p. p138 26. Chapter 14 Rheumatoid Arthritis - p. 138 27. Chapter 15 Systemic Lupus Erythematosus - p. 154 28. Chapter 16 Drug-induced Lupus Erythematosus - p. 178 29. Chapter 17 Systemic Sclerosis - p. 184 30. Chapter 18 Scleroderma Mimics - p. 203 31. Chapter 19 Idiopathic Inflammatory Myopathies - p. 210 32. Chapter 20 Mixed Connective Tissue Disease, Overlap Syndromes, and Undifferentiated Connective Tissue Disease - p. 221 33. Chapter 21 Sjögren Disease - p. 228 34. Chapter 22 Antiphospholipid Syndrome - p. 239 35. Chapter 23 Adult-Onset Still’s Disease - p. 251 36. Chapter 24 Polymyalgia Rheumatica - p. 257 37. SECTION IV The Vasculitides and Related Disorders - p. p264 38. Chapter 25 Approach for Patients With Suspected Vasculitis - p. 264 39. Chapter 26 Large-Vessel Vasculitis: Giant Cell Arteritis, Takayasu Arteritis, and Aortitis - p. 273 40. Chapter 27 Polyarteritis Nodosa, Thromboangiitis Obliterans, and Primary Central Nervous System Vasculitis - p. 285 41. Chapter 28 Antineutrophil Cytoplasmic Antibody-Associated Vasculitis - p. 297 42. Chapter 29 Immune Complex-Mediated Small-Vessel Vasculitides - p. 315 43. Chapter 30 Cryoglobulinemia - p. 324 44. Chapter 31 Behçet Syndrome - p. 333 45. Chapter 32 Relapsing Polychondritis - p. 340 46. SECTION V Seronegative Spondyloarthropathies - p. p349 47. Chapter 33 Axial Spondyloarthritis - p. 349 48. Chapter 34 Rheumatic Manifestations of Gastrointestinal and Hepatobiliary Diseases - p. 358 49. Chapter 35 Reactive Arthritis - p. 367 50. Chapter 36 Arthritis Associated With Psoriasis and Other Skin Diseases - p. 378 51. SECTION VI Arthritis Associated With Infectious Agents - p. p387 52. Chapter 37 Bacterial Septic Arthritis, Bursitis, and Osteomyelitis - p. 387 53. Chapter 38 Lyme Disease - p. 397 54. Chapter 39 Mycobacterial and Fungal Joint and Bone Diseases - p. 406 55. Chapter 40 Viral Arthritides - p. 415 56. Chapter 41 HIV-Associated Rheumatic Syndromes - p. 424 57. Chapter 42 Whipple Disease - p. 432 58. Chapter 43 Acute Rheumatic Fever and Poststreptococcal Arthritis - p. 438 59. SECTION VII Rheumatic Disorders Associated With Metabolic, Endocrine, and Hematologic Diseases - p. p445 60. Chapter 44 Gout - p. 445 61. Chapter 45 Calcium Pyrophosphate Deposition Disease - p. 456 62. Chapter 46 Basic Calcium Phosphate and Other Crystalline Diseases - p. 464 63. Chapter 47 Endocrine-Associated Arthropathies - p. 471 64. Chapter 48 Arthropathies Associated With Hematologic Diseases - p. 481 65. Chapter 49 Malignancy-Associated Rheumatic Disorders - p. 489 66. SECTION VIII Bone and Cartilage Disorders - p. p498 67. Chapter 50 Osteoarthritis - p. 498 68. Chapter 51 Metabolic Bone Disease - p. 510 69. Chapter 52 Paget Disease of Bone - p. 521 70. Chapter 53 Osteonecrosis - p. 527 71. SECTION IX Hereditary, Congenital, and Inborn Errors of Metabolism Associated With Rheumatic Syndromes - p. p534 72. Chapter 54 Heritable Connective Tissue Diseases - p. 534 73. Chapter 55 Inborn Errors of Metabolism Affecting Connective Tissue - p. 543 74. Chapter 56 Storage and Deposition Diseases - p. 550 75. Chapter 57 Rheumatologic Manifestations of the Primary Immunodeficiency Syndromes - p. 556 76. Chapter 58 Skeletal Dysplasias - p. 565 77. SECTION X Nonarticular and Regional Musculoskeletal Disorders - p. p537 78. Chapter 59 Approach for the Patient With Neck and Low Back Pain - p. 573 79. Chapter 60 Fibromyalgia - p. 583 80. Chapter 61 Regional Musculoskeletal Disorders - p. 595 81. Chapter 62 Sports Medicine and Occupational Injuries - p. 605 82. Chapter 63 Entrapment Neuropathies - p. 613 83. Chapter 64 Complex Regional Pain Syndrome - p. 623 84. SECTION XI Neoplasms and Tumor-like Lesions - p. p633 85. Chapter 65 Benign and Malignant Tumors of Joints and Synovium - p. 633 86. Chapter 66 Common Bony Lesions: Radiographic Features - p. 638 87. SECTION XII Pediatric Rheumatic Diseases - p. p657 88. Chapter 67 Approach to the Child With Joint Pain - p. 657 89. Chapter 68 Juvenile Idiopathic Arthritis - p. 666 90. Chapter 69 Juvenile Systemic Connective Tissue Diseases and Vasculitides - p. 675 91. Chapter 70 Kawasaki Disease - p. 685 92. SECTION XIII Miscellaneous Rheumatic Disorders - p. p701 93. Chapter 71 Genetic Muscle Diseases: Metabolic and Other Genetic Muscle Disorders - p. 690 94. Chapter 72 Amyloidosis - p. 701 95. Chapter 73 Raynaud’s Phenomenon - p. 710 96. Chapter 74 Autoimmune Eye and Ear Disorders - p. 719 97. Chapter 75 Rheumatic Syndromes Associated With Sarcoidosis - p. 735 98. Chapter 76 IgG4-Related Disease - p. 746 99. Chapter 77 Rheumatic Disorders in Patients on Dialysis - p. 754 100. Chapter 78 Rheumatic Disease and the Pregnant Patient - p. 762 101. Chapter 79 Autoinflammatory Syndromes - p. 774 102. Chapter 80 Odds and Ends - p. 788 103. SECTION XIV Management of the Rheumatic Diseases - p. p802 104. Chapter 81 Nonsteroidal Anti-Inflammatory Drugs - p. 802 105. Chapter 82 Glucocorticoids—Systemic and Injectable - p. 808 106. Chapter 83 DMARDs: csDMARDs and tsDMARDs - p. 818 107. Chapter 84 Disease Modifying Anti-Rheumatic Drugs: Biologic Agents - p. 831 108. Chapter 85 Immunosuppressive and Immunoregulatory Agents - p. 849 109. Chapter 86 Hypouricemic Agents and Colchicine - p. 859 110. Chapter 87 Bone Strengthening Agents - p. 867 111. Chapter 88 Rehabilitative Techniques - p. 881 112. Chapter 89 Surgical Treatment and Rheumatic Diseases - p. 891 113. Chapter 90 Disability - p. 903 114. SECTION XV Final Secrets - p. p910 115. Chapter 91 Complementary and Alternative Medicine - p. 910 116. Chapter 92 History, the Arts, and Rheumatic Diseases - p. 920 117. SECTION XVI eAppendix Board-Style Questions - p. p926 118. Rheumatology Secrets Electronic Online Question Bank - p. page_1.e1 119. Index - p. 926
