Sex, Gender, and Epigenetics: From Molecule to Bedside explores our expanding knowledge of the science of epigenetics in which gene expression is modified as a consequence of small chemical additions to various components of the genome. The book provides an overview of the field, describing the epigenetic phenomena that unite biological sex and environmental experience to create the unique phenome of each individual. The book also analyzes the impact of ancestors’ environmental experience on subsequent generations through the sex-specific transmission of environmentally induced epigenetic modifications.
Here, international leaders in the field discuss both sex-specific normal physiology and the experience of disease, with chapters dedicated to fetal programming, the microbiome, cancer, bipolar disorder and schizophrenia, embryogenesis, and oocyte aging, among other topics.
1. Sex, Gender, and Epigenetics - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. Contributors - p. xiii 8. Chapter 1 Exploring how we become what we are - p. 1 9. Chapter 2 A critical view of the revolution of precision medicine: genetics, epigenetics, sex, and gender - p. 9 10. Chapter 3 Genetic and epigenetic contributions to female-biased lupus disease: X-chromosome inactivation in immune cells - p. 27 11. Chapter 4 Genetic, molecular, and cellular determinations of sex-specific cardiovascular traits - p. 35 12. Chapter 5 Epigenetics and mental and physical health of children born after ART - p. 47 13. Chapter 6 Epigenetic aspects of male infertility treatment - p. 53 14. Chapter 7 Evidence for assisted reproductive technology associated epigenetic variation in humans - p. 69 15. Chapter 8 Deconvoluting the functional role of DNA methylation in trauma; Implications for epigenetic therapy and prospects of targeted “epigenetic therapy” - p. 81 16. Chapter 9 Antenatal Origins of Health and Disease—A clinician's perspective - p. 93 17. Chapter 10 Maternal anxiety during pregnancy and the lack of fetal DNA methylation in cord blood - p. 105 18. Chapter 11 DNA methylation and other epigenetic modifications mediating the transgenerational impacts of paternal exposures on offspring phenotypes - p. 125 19. Chapter 12 Epigenetics and psychiatry - p. 139 20. Chapter 13 Integrative transcriptomics reveals sexually dimorphic control of the cholinergic/neurokine interface in schizophrenia and bipolar disorder - p. 153 21. Chapter 14 Gender specific neurobehavioral and gene expression changes in a valproic acid (VPA)–induced mouse model of autistic like behavior and correction by S-adenosylmethionine (SAMe) - p. 163 22. Chapter 15 Genetics and epigenetics of the one-carbon metabolism pathway in autism spectrum disorder: Role of a sex-specific brain epigenome - p. 181 23. Chapter 16 Novel mechanisms for gene regulation: Chemical tags on RNA molecules - p. 193 24. Chapter 17 Genes, environments, and epigenetics - p. 207 25. Chapter 18 Epigenetic mechanisms linking poor maternal nutrition during pregnancy to the cardio-metabolic health of offspring - p. 225 26. Chapter 19 Epigenetic aspects of human reproduction and early pregnancy - p. 237 27. Chapter 20 Sex-specific impact of maternal metabolic environment on the development of the offspring, from gametogenesis to infancy and beyond - p. 245 28. Chapter 21 Mitochondria as epigenetic regulators of reproductive aging - p. 251 29. Chapter 22 The fetal programming of telomere biology hypothesis - p. 261 30. Chapter 23 Brain organoids modeling of genetic and environmental impact on neurodevelopmental traits - p. 281 31. Index - p. 291
Sex, Gender, and Epigenetics: From Molecule to Bedside explores our expanding knowledge of the science of epigenetics in which gene expression is modified as a consequence of small chemical additions to various components of the genome. The book provides an overview of the field, describing the epigenetic phenomena that unite biological sex and environmental experience to create the unique phenome of each individual. The book also analyzes the impact of ancestors’ environmental experience on subsequent generations through the sex-specific transmission of environmentally induced epigenetic modifications.
Here, international leaders in the field discuss both sex-specific normal physiology and the experience of disease, with chapters dedicated to fetal programming, the microbiome, cancer, bipolar disorder and schizophrenia, embryogenesis, and oocyte aging, among other topics.
1. Sex, Gender, and Epigenetics - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. Contributors - p. xiii 8. Chapter 1 Exploring how we become what we are - p. 1 9. Chapter 2 A critical view of the revolution of precision medicine: genetics, epigenetics, sex, and gender - p. 9 10. Chapter 3 Genetic and epigenetic contributions to female-biased lupus disease: X-chromosome inactivation in immune cells - p. 27 11. Chapter 4 Genetic, molecular, and cellular determinations of sex-specific cardiovascular traits - p. 35 12. Chapter 5 Epigenetics and mental and physical health of children born after ART - p. 47 13. Chapter 6 Epigenetic aspects of male infertility treatment - p. 53 14. Chapter 7 Evidence for assisted reproductive technology associated epigenetic variation in humans - p. 69 15. Chapter 8 Deconvoluting the functional role of DNA methylation in trauma; Implications for epigenetic therapy and prospects of targeted “epigenetic therapy” - p. 81 16. Chapter 9 Antenatal Origins of Health and Disease—A clinician's perspective - p. 93 17. Chapter 10 Maternal anxiety during pregnancy and the lack of fetal DNA methylation in cord blood - p. 105 18. Chapter 11 DNA methylation and other epigenetic modifications mediating the transgenerational impacts of paternal exposures on offspring phenotypes - p. 125 19. Chapter 12 Epigenetics and psychiatry - p. 139 20. Chapter 13 Integrative transcriptomics reveals sexually dimorphic control of the cholinergic/neurokine interface in schizophrenia and bipolar disorder - p. 153 21. Chapter 14 Gender specific neurobehavioral and gene expression changes in a valproic acid (VPA)–induced mouse model of autistic like behavior and correction by S-adenosylmethionine (SAMe) - p. 163 22. Chapter 15 Genetics and epigenetics of the one-carbon metabolism pathway in autism spectrum disorder: Role of a sex-specific brain epigenome - p. 181 23. Chapter 16 Novel mechanisms for gene regulation: Chemical tags on RNA molecules - p. 193 24. Chapter 17 Genes, environments, and epigenetics - p. 207 25. Chapter 18 Epigenetic mechanisms linking poor maternal nutrition during pregnancy to the cardio-metabolic health of offspring - p. 225 26. Chapter 19 Epigenetic aspects of human reproduction and early pregnancy - p. 237 27. Chapter 20 Sex-specific impact of maternal metabolic environment on the development of the offspring, from gametogenesis to infancy and beyond - p. 245 28. Chapter 21 Mitochondria as epigenetic regulators of reproductive aging - p. 251 29. Chapter 22 The fetal programming of telomere biology hypothesis - p. 261 30. Chapter 23 Brain organoids modeling of genetic and environmental impact on neurodevelopmental traits - p. 281 31. Index - p. 291
