Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xi 8. About the editor - p. xiii 9. Preface - p. xv 10. Acknowledgment - p. xvii 11. Section I: Sirtuins, neurodegenerative disease, lifespan extension, and aging - p. xviii 12. Chapter 1. Novel treatment strategies for neurodegenerative disease with sirtuins - p. 3 13. Chapter 2. NAD+: a crucial regulator of sirtuin activity in aging - p. 23 14. Chapter 3. Sirtuins and life span extension - p. 37 15. Chapter 4. Sirtuins and aging - p. 49 16. Chapter 5. Sirtuins in the biology of aging - p. 79 17. Chapter 6. Sirtuins as regulators and the regulated molecules of exosomes - p. 91 18. Chapter 7. Sirtuins in aging, age-related pathologies and their association with circadian rhythm - p. 103 19. Chapter 8. Sirtuins, mitochondria, and the melatonergic pathway in Alzheimer’s disease - p. 117 20. Chapter 9. Sirtuins, melatonin, and the relevance of circadian oscillators - p. 137 21. Chapter 10. Epigenetic role of sirtuins in neurodegenerative brain disorders - p. 153 22. Chapter 11. Sirtuins and stem cell maintenance, proliferation, and differentiation - p. 175 23. Chapter 12. Sirtuins in mechanistic target of rapamycin complex 1 signaling - p. 191 24. Chapter 13. Free-radical redox timer, sirtuins and aging: from chemistry of free radicals to systems theory of reliability - p. 213 25. Chapter 14. Sirtuins, mitochondria, and exercise in health and disease - p. 225 26. Section II: Sirtuins, cardiovascular disease and end-organ disease - p. 234 27. Chapter 15. Scope to develop sirtuins modulators as a therapy to attenuate cardiac complications - p. 241 28. Chapter 16. Role of sirtuins in cardiovascular diseases - p. 261 29. Chapter 17. Targeting sirtuins to modulate energy metabolism in heart disease - p. 285 30. Chapter 18. Sirtuin 1 mediates hepatoprotective effects of resveratrol-like compounds in experimental liver injury - p. 295 31. Chapter 19. Sirtuins as key players in aging and kidney dysfunction - p. 309 32. Chapter 20. Role of sirtuins in liver diseases - p. 329 33. Chapter 21. Sirtuins in bone and cartilage biology - p. 341 34. Chapter 22. Vitagenes in avian biology: protective functions of sirtuins - p. 353 35. Chapter 23. Sirtuins in hematopoiesis and blood malignancies - p. 373 36. Index - p. 393
Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xi 8. About the editor - p. xiii 9. Preface - p. xv 10. Acknowledgment - p. xvii 11. Section I: Sirtuins, neurodegenerative disease, lifespan extension, and aging - p. xviii 12. Chapter 1. Novel treatment strategies for neurodegenerative disease with sirtuins - p. 3 13. Chapter 2. NAD+: a crucial regulator of sirtuin activity in aging - p. 23 14. Chapter 3. Sirtuins and life span extension - p. 37 15. Chapter 4. Sirtuins and aging - p. 49 16. Chapter 5. Sirtuins in the biology of aging - p. 79 17. Chapter 6. Sirtuins as regulators and the regulated molecules of exosomes - p. 91 18. Chapter 7. Sirtuins in aging, age-related pathologies and their association with circadian rhythm - p. 103 19. Chapter 8. Sirtuins, mitochondria, and the melatonergic pathway in Alzheimer’s disease - p. 117 20. Chapter 9. Sirtuins, melatonin, and the relevance of circadian oscillators - p. 137 21. Chapter 10. Epigenetic role of sirtuins in neurodegenerative brain disorders - p. 153 22. Chapter 11. Sirtuins and stem cell maintenance, proliferation, and differentiation - p. 175 23. Chapter 12. Sirtuins in mechanistic target of rapamycin complex 1 signaling - p. 191 24. Chapter 13. Free-radical redox timer, sirtuins and aging: from chemistry of free radicals to systems theory of reliability - p. 213 25. Chapter 14. Sirtuins, mitochondria, and exercise in health and disease - p. 225 26. Section II: Sirtuins, cardiovascular disease and end-organ disease - p. 234 27. Chapter 15. Scope to develop sirtuins modulators as a therapy to attenuate cardiac complications - p. 241 28. Chapter 16. Role of sirtuins in cardiovascular diseases - p. 261 29. Chapter 17. Targeting sirtuins to modulate energy metabolism in heart disease - p. 285 30. Chapter 18. Sirtuin 1 mediates hepatoprotective effects of resveratrol-like compounds in experimental liver injury - p. 295 31. Chapter 19. Sirtuins as key players in aging and kidney dysfunction - p. 309 32. Chapter 20. Role of sirtuins in liver diseases - p. 329 33. Chapter 21. Sirtuins in bone and cartilage biology - p. 341 34. Chapter 22. Vitagenes in avian biology: protective functions of sirtuins - p. 353 35. Chapter 23. Sirtuins in hematopoiesis and blood malignancies - p. 373 36. Index - p. 393
