Sjogren's Syndrome: Novel Insights in Pathogenic, Clinical and Therapeutic Aspects provides the reader with an overview of current knowledge about Sjogren's Syndrome. The book summarizes the huge amount of literature concerning related advances in genetic background, pathogenesis, clinical picture, and therapeutic approaches. It integrates basic immunology concepts, clinical aspects, and pharmacological issues.
Scientific progress has allowed us to unmask novel pathogenic mechanisms, to perform genome wide studies, and to identify clinical and serological features associated with different disease subsets and, eventually, different disease prognoses. In addition, the increasing knowledge about SS pathogenesis provides the rationale to employ targeted therapies in SS as has already occurred in rheumatoid arthritis and systemic lupus erythematosus.
1. Chapter 1 Introduction - p. 2 2. Chapter 2 Clinical Features - p. 12 3. Chapter 3 Management of Sjögren’s Syndrome - p. 35 4. Chapter 4 Classification Criteria for Sjögren’s Syndrome - p. 47 5. Chapter 5 Imaging Procedures Useful for the Diagnosis of Sjögren’s Syndrome - p. 61 6. Chapter 6 Sjögren’s Syndrome–Associated Lymphoma - p. 73 7. Chapter 7 Spontaneous and Inducible Animal Models of Sjögren’s Syndrome - p. 99 8. Chapter 8 Genetics, Genomics, Gene Expression Profiling, and Epigenetics in Sjögren’s Syndrome - p. 119 9. Chapter 9 Autoantigens and Autoantibodies in the Pathogenesis of Sjögren’s Syndrome - p. 141 10. Chapter 10 Sjögren’s Syndrome and Environmental Factors - p. 157 11. Chapter 11 Histology of Sjögren’s Syndrome - p. 171 12. Chapter 12 Glandular Epithelium - p. 189 13. Chapter 13 T Cells in the Pathogenesis of Sjögren’s Syndrome - p. 205 14. Chapter 14 B Lymphocytes in Primary Sjögren’s Syndrome - p. 217 15. Chapter 15 Cytokines, Chemokines, and the Innate Immune System in Sjögren’s Syndrome - p. 229 16. Chapter 16 Autoantibodies and Autoantigens in Sjögren’s Syndrome - p. 241 17. Chapter 17 Outcome Measures in Sjögren’s Syndrome and Perspectives in Clinical Trial Design - p. 263 18. Chapter 18 Novel Therapeutic Strategies in Sjögren’s Syndrome - p. 273 19. Chapter 19 Novel Therapeutic Strategies in Sjögren’s Syndrome - p. 291 20. Chapter 20 New Biological Avenues for Sjögren’s Syndrome - p. 299 21. Index - p. 319
Sjogren's Syndrome: Novel Insights in Pathogenic, Clinical and Therapeutic Aspects provides the reader with an overview of current knowledge about Sjogren's Syndrome. The book summarizes the huge amount of literature concerning related advances in genetic background, pathogenesis, clinical picture, and therapeutic approaches. It integrates basic immunology concepts, clinical aspects, and pharmacological issues.
Scientific progress has allowed us to unmask novel pathogenic mechanisms, to perform genome wide studies, and to identify clinical and serological features associated with different disease subsets and, eventually, different disease prognoses. In addition, the increasing knowledge about SS pathogenesis provides the rationale to employ targeted therapies in SS as has already occurred in rheumatoid arthritis and systemic lupus erythematosus.
1. Chapter 1 Introduction - p. 2 2. Chapter 2 Clinical Features - p. 12 3. Chapter 3 Management of Sjögren’s Syndrome - p. 35 4. Chapter 4 Classification Criteria for Sjögren’s Syndrome - p. 47 5. Chapter 5 Imaging Procedures Useful for the Diagnosis of Sjögren’s Syndrome - p. 61 6. Chapter 6 Sjögren’s Syndrome–Associated Lymphoma - p. 73 7. Chapter 7 Spontaneous and Inducible Animal Models of Sjögren’s Syndrome - p. 99 8. Chapter 8 Genetics, Genomics, Gene Expression Profiling, and Epigenetics in Sjögren’s Syndrome - p. 119 9. Chapter 9 Autoantigens and Autoantibodies in the Pathogenesis of Sjögren’s Syndrome - p. 141 10. Chapter 10 Sjögren’s Syndrome and Environmental Factors - p. 157 11. Chapter 11 Histology of Sjögren’s Syndrome - p. 171 12. Chapter 12 Glandular Epithelium - p. 189 13. Chapter 13 T Cells in the Pathogenesis of Sjögren’s Syndrome - p. 205 14. Chapter 14 B Lymphocytes in Primary Sjögren’s Syndrome - p. 217 15. Chapter 15 Cytokines, Chemokines, and the Innate Immune System in Sjögren’s Syndrome - p. 229 16. Chapter 16 Autoantibodies and Autoantigens in Sjögren’s Syndrome - p. 241 17. Chapter 17 Outcome Measures in Sjögren’s Syndrome and Perspectives in Clinical Trial Design - p. 263 18. Chapter 18 Novel Therapeutic Strategies in Sjögren’s Syndrome - p. 273 19. Chapter 19 Novel Therapeutic Strategies in Sjögren’s Syndrome - p. 291 20. Chapter 20 New Biological Avenues for Sjögren’s Syndrome - p. 299 21. Index - p. 319
