This title is a greatly expanded and updated second edition of the original volume published by Elsevier in 1986. New material has been integrated with the original content in an organized and comprehensive manner.
Five new chapters have been included, which review over one and a half decades of research into lipid-coated microbubbles (LCM) and their medical applications. The new chapters contain much experimental data, which is examined in detail, along with relevant current literature.
This current edition builds on the original work in effectively filling the gap in the market for a comprehensive account of the surfactant stabilization of coated microbubbles.
1. Cover Image 2. Title Page 3. Copyright 4. Dedication 5. Preface 6. Table of Contents 7. Chapter 1 Occurrence of Dilute Gas-in-Liquid Emulsions in Natural Waters 8. Chapter 2 Early Work with Aqueous Carbohydrate Gels 9. Chapter 3 Comparison of Aqueous Soil Extracts with Carbohydrate Gels 10. Chapter 4 Characteristic Glycopeptide Fraction of Natural Microbubble Surfactant 11. Chapter 5 Ecological Chemistry of Microbubble Surfactant 12. Chapter 6 Surface Properties of Microbubble-Surfactant Monolayers 13. Chapter 7 Structure of Predominant Surfactant Components Stabilizing Natural Microbubbles 14. Chapter 8 Stable Microbubbles in Physiological Fluids: Competing Hypotheses 15. Chapter 9 Concentrated Gas-in-Liquid Emulsions in Artificial Media. I. Demonstration by Laser-Light Scattering 16. Chapter 10 Concentrated Gas-in-Liquid Emulsions in Artificial Media. II. Characterization by Photon Correlation Spectroscopy 17. Chapter 11 Concentrated Gas-in-Liquid Emulsions in Artificial Media. III. Review of Molecular Mechanisms Involved in Microbubble Stabilization 18. Chapter 12 Targeted Imaging of Tumors, and Targeted Cavitation Therapy, with Lipid-Coated Microbubbles (LCM) 19. Chapter 13 Targeted Drug-Delivery Therapy of Tumors Using LCM 20. Chapter 14 Proposed Mechanism of Selective LCM Uptake by Tumor Cells: Role of Lipoprotein Receptor-Mediated Endocytic Pathways 21. Chapter 15 Endocytotic Events Versus Particle Size: Multidisciplinary Analyses Demonstrate LCM Sizes are Mostly Submicron 22. Chapter 16 LCM and Nanoparticle Subpopulations for Drug Delivery 23. Chapter 17 Composition of LCM Governing Interplay with Nanoparticle Subpopulation 24. Chapter 18 Targeted Nanoparticle Subpopulation: Comparison with Self-Nanoemulsifying Drug-Delivery Systems in Pharmaceutical Research 25. Chapter 19 Clinical Development of an “LCM/Nanoparticle-Derived” Formulation: A Nanoemulsion Based Upon “Dispersed LMN” 26. Chapter 20 Selected Parenteral Lipid Nanoemulsions Under Clinical Study: Comparison Concerning Passive Accumulation in Tumors, Active Targeting of Tumors, and Validation Status 27. Chapter 21 Supplementary Operational Benefits Concerning “LCM/Nanoparticle-Derived” Formulations: Relation to Lipid-Nanoemulsion Structure 28. Chapter 22 Biological Lipid Polymorphs: Preferred Cubic Phase of “Dispersed LMN” 29. Chapter 23 Nonlamellar Phase(s) Facilitating Membrane Fusion: Endocytosis of Dispersed LMN 30. Chapter 24 Receptor-Mediated Endocytosis of (Mixed-Lipid) Dispersed LMN 31. Chapter 25 Further Chemotherapy with Lipid Nanoemulsions: Targeting Certain Hyperproliferative Diseases, as well as Neoplasias, via “Lipoprotein Receptor”-Mediated Endocytosis 32. Chapter 26 Related Clinical Trials and Human Epidemiological Studies 33. Chapter 27 Aspects of Future R&D Regarding Targeted Lipid Nanoemulsions 34. Subject Index
This title is a greatly expanded and updated second edition of the original volume published by Elsevier in 1986. New material has been integrated with the original content in an organized and comprehensive manner.
Five new chapters have been included, which review over one and a half decades of research into lipid-coated microbubbles (LCM) and their medical applications. The new chapters contain much experimental data, which is examined in detail, along with relevant current literature.
This current edition builds on the original work in effectively filling the gap in the market for a comprehensive account of the surfactant stabilization of coated microbubbles.
1. Cover Image 2. Title Page 3. Copyright 4. Dedication 5. Preface 6. Table of Contents 7. Chapter 1 Occurrence of Dilute Gas-in-Liquid Emulsions in Natural Waters 8. Chapter 2 Early Work with Aqueous Carbohydrate Gels 9. Chapter 3 Comparison of Aqueous Soil Extracts with Carbohydrate Gels 10. Chapter 4 Characteristic Glycopeptide Fraction of Natural Microbubble Surfactant 11. Chapter 5 Ecological Chemistry of Microbubble Surfactant 12. Chapter 6 Surface Properties of Microbubble-Surfactant Monolayers 13. Chapter 7 Structure of Predominant Surfactant Components Stabilizing Natural Microbubbles 14. Chapter 8 Stable Microbubbles in Physiological Fluids: Competing Hypotheses 15. Chapter 9 Concentrated Gas-in-Liquid Emulsions in Artificial Media. I. Demonstration by Laser-Light Scattering 16. Chapter 10 Concentrated Gas-in-Liquid Emulsions in Artificial Media. II. Characterization by Photon Correlation Spectroscopy 17. Chapter 11 Concentrated Gas-in-Liquid Emulsions in Artificial Media. III. Review of Molecular Mechanisms Involved in Microbubble Stabilization 18. Chapter 12 Targeted Imaging of Tumors, and Targeted Cavitation Therapy, with Lipid-Coated Microbubbles (LCM) 19. Chapter 13 Targeted Drug-Delivery Therapy of Tumors Using LCM 20. Chapter 14 Proposed Mechanism of Selective LCM Uptake by Tumor Cells: Role of Lipoprotein Receptor-Mediated Endocytic Pathways 21. Chapter 15 Endocytotic Events Versus Particle Size: Multidisciplinary Analyses Demonstrate LCM Sizes are Mostly Submicron 22. Chapter 16 LCM and Nanoparticle Subpopulations for Drug Delivery 23. Chapter 17 Composition of LCM Governing Interplay with Nanoparticle Subpopulation 24. Chapter 18 Targeted Nanoparticle Subpopulation: Comparison with Self-Nanoemulsifying Drug-Delivery Systems in Pharmaceutical Research 25. Chapter 19 Clinical Development of an “LCM/Nanoparticle-Derived” Formulation: A Nanoemulsion Based Upon “Dispersed LMN” 26. Chapter 20 Selected Parenteral Lipid Nanoemulsions Under Clinical Study: Comparison Concerning Passive Accumulation in Tumors, Active Targeting of Tumors, and Validation Status 27. Chapter 21 Supplementary Operational Benefits Concerning “LCM/Nanoparticle-Derived” Formulations: Relation to Lipid-Nanoemulsion Structure 28. Chapter 22 Biological Lipid Polymorphs: Preferred Cubic Phase of “Dispersed LMN” 29. Chapter 23 Nonlamellar Phase(s) Facilitating Membrane Fusion: Endocytosis of Dispersed LMN 30. Chapter 24 Receptor-Mediated Endocytosis of (Mixed-Lipid) Dispersed LMN 31. Chapter 25 Further Chemotherapy with Lipid Nanoemulsions: Targeting Certain Hyperproliferative Diseases, as well as Neoplasias, via “Lipoprotein Receptor”-Mediated Endocytosis 32. Chapter 26 Related Clinical Trials and Human Epidemiological Studies 33. Chapter 27 Aspects of Future R&D Regarding Targeted Lipid Nanoemulsions 34. Subject Index
