Stem Cells and Signaling Pathways provides mechanistic insights into the role of stem cells to combat the COVID-19 outbreak and other pathologies where a cytokine storm is the cause of concern for e.g., radiation exposure, multiple organ failure and sepsis. The advent of SARS-CoV-2 resulted in a global pandemic, putting individuals with other comorbidities at a higher risk of infection. The whole world witnessed a massive shortage of medical and other essential supplies needed to combat the virus. That said, stem cell therapy has emerged as a potential treatment for viral diseases, including but not limited to COVID-19.
Interestingly, the clinical trials in the patients having COVID-19 complications depicted faster recovery in patients post mesenchymal stem cells therapy owing to the decreased cytokines levels, anti-viral effects and regeneration of the infected tissue.
1. Stem Cells and Signaling Pathways - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Dedication - p. Page v 7. Contents - p. Page vii 8. List of contributors - p. Page viii 9. Preface - p. Page viii 10. List of Illustrations - p. Page x 11. List of Tables - p. Page xi 12. Chapter 1 : Regulation of mesenchymal stem cell differentiation by key cell signaling pathways - p. Page xi 13. Chapter 2 : Stem signaling molecules and pathways: implications in the regulation of fate and proliferation potential - p. Page 19 14. Chapter 3 : The role of Yamanaka factors in induced pluripotent stem cells and embryonic stem cell signaling - p. Page 36 15. Chapter 4 : Purinergic signaling in stem cell growth - p. Page 51 16. Chapter 5 : Cutaneous homeostasis: a balancing cross-talk between epidermal stem cell pool and regulatory pathways - p. Page 63 17. Chapter 6 : Role of stem cells in cardiac bioengineering - p. Page 81 18. Chapter 7 : Stem cell signaling molecules and pathways in liver regeneration - p. Page 98 19. Chapter 8 : Role of stem cells in osteoblastic miRNA and bone tissue regeneration - p. Page 122 20. Chapter 9 : Stem cells and signaling pathways in human reproductive system - p. Page 142 21. Chapter 10 : Hormonal impacts on stem cell lineages and related signaling pathways - p. Page 161 22. Chapter 11 : Unravelling the crosstalk of Hedgehog with Wnt, Notch and TGF-β signaling pathways - p. Page 176 23. Chapter 12 : Stem cell aging: role of signaling pathways and microRNAs - p. Page 195 24. Chapter 13 : Slowdown of aging and neurodegenerative diseases by extremolytes - p. Page 217 25. Chapter 14 : Stem cells and therapy: cancer stem cells and targeted therapy with DNA repair inhibitors - p. Page 239 26. Chapter 15 : The potential role of stem cells in multiple sclerosis therapies - p. Page 253 27. Chapter 16 : Stem cells signaling pathways and surface receptors: implications for multiple sclerosis treatment - p. Page 267 28. Chapter 17 : Mechanistic role of stem cells in the pathogenesis and treatment of oral diseases: current insights and future directions - p. Page 282 29. Chapter 18 : Stem cell–based approach in treatment of periodontitis - p. Page 294 30. Chapter 19 : Role of probiotics in modulation of stem cell progeny in human gastrointestinal disorders - p. Page 313 31. Chapter 20 : Implications of stem cell–associated signals in pathogenesis of lipid disorders - p. Page 336 32. Chapter 21 : Stem cell’s potential role in the treatment of diabetes mellitus - p. Page 356 33. Chapter 22 : Mesenchymal stem cells in chronic kidney disease and therapeutic signaling pathways - p. Page 376 34. Chapter 23 : Current advances and challenges in stem cell–based therapy for chronic kidney disease - p. Page 393 35. Chapter 24 : Stem cell therapeutic approaches and signaling pathways in rheumatoid arthritis and osteoarthritis - p. Page 408 36. Chapter 25 : Potential role of stem cells in the pathogenesis of endometriosis - p. Page 428 37. Chapter 26 : Potential role of traditional medicine in stem cell research - p. Page 446 38. Index - p. Page 459
Stem Cells and Signaling Pathways provides mechanistic insights into the role of stem cells to combat the COVID-19 outbreak and other pathologies where a cytokine storm is the cause of concern for e.g., radiation exposure, multiple organ failure and sepsis. The advent of SARS-CoV-2 resulted in a global pandemic, putting individuals with other comorbidities at a higher risk of infection. The whole world witnessed a massive shortage of medical and other essential supplies needed to combat the virus. That said, stem cell therapy has emerged as a potential treatment for viral diseases, including but not limited to COVID-19.
Interestingly, the clinical trials in the patients having COVID-19 complications depicted faster recovery in patients post mesenchymal stem cells therapy owing to the decreased cytokines levels, anti-viral effects and regeneration of the infected tissue.
1. Stem Cells and Signaling Pathways - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Dedication - p. Page v 7. Contents - p. Page vii 8. List of contributors - p. Page viii 9. Preface - p. Page viii 10. List of Illustrations - p. Page x 11. List of Tables - p. Page xi 12. Chapter 1 : Regulation of mesenchymal stem cell differentiation by key cell signaling pathways - p. Page xi 13. Chapter 2 : Stem signaling molecules and pathways: implications in the regulation of fate and proliferation potential - p. Page 19 14. Chapter 3 : The role of Yamanaka factors in induced pluripotent stem cells and embryonic stem cell signaling - p. Page 36 15. Chapter 4 : Purinergic signaling in stem cell growth - p. Page 51 16. Chapter 5 : Cutaneous homeostasis: a balancing cross-talk between epidermal stem cell pool and regulatory pathways - p. Page 63 17. Chapter 6 : Role of stem cells in cardiac bioengineering - p. Page 81 18. Chapter 7 : Stem cell signaling molecules and pathways in liver regeneration - p. Page 98 19. Chapter 8 : Role of stem cells in osteoblastic miRNA and bone tissue regeneration - p. Page 122 20. Chapter 9 : Stem cells and signaling pathways in human reproductive system - p. Page 142 21. Chapter 10 : Hormonal impacts on stem cell lineages and related signaling pathways - p. Page 161 22. Chapter 11 : Unravelling the crosstalk of Hedgehog with Wnt, Notch and TGF-β signaling pathways - p. Page 176 23. Chapter 12 : Stem cell aging: role of signaling pathways and microRNAs - p. Page 195 24. Chapter 13 : Slowdown of aging and neurodegenerative diseases by extremolytes - p. Page 217 25. Chapter 14 : Stem cells and therapy: cancer stem cells and targeted therapy with DNA repair inhibitors - p. Page 239 26. Chapter 15 : The potential role of stem cells in multiple sclerosis therapies - p. Page 253 27. Chapter 16 : Stem cells signaling pathways and surface receptors: implications for multiple sclerosis treatment - p. Page 267 28. Chapter 17 : Mechanistic role of stem cells in the pathogenesis and treatment of oral diseases: current insights and future directions - p. Page 282 29. Chapter 18 : Stem cell–based approach in treatment of periodontitis - p. Page 294 30. Chapter 19 : Role of probiotics in modulation of stem cell progeny in human gastrointestinal disorders - p. Page 313 31. Chapter 20 : Implications of stem cell–associated signals in pathogenesis of lipid disorders - p. Page 336 32. Chapter 21 : Stem cell’s potential role in the treatment of diabetes mellitus - p. Page 356 33. Chapter 22 : Mesenchymal stem cells in chronic kidney disease and therapeutic signaling pathways - p. Page 376 34. Chapter 23 : Current advances and challenges in stem cell–based therapy for chronic kidney disease - p. Page 393 35. Chapter 24 : Stem cell therapeutic approaches and signaling pathways in rheumatoid arthritis and osteoarthritis - p. Page 408 36. Chapter 25 : Potential role of stem cells in the pathogenesis of endometriosis - p. Page 428 37. Chapter 26 : Potential role of traditional medicine in stem cell research - p. Page 446 38. Index - p. Page 459
