Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties.
This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki’s book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book.
1. Chapter 1 Introduction to structure-function relationships - p. 1 2. Chapter 2 Extracellular matrix background material: Building blocks, general structure, mechanics, relation to cells, and evolutionary aspects - p. 9 3. Chapter 3 The collagen molecule - p. 29 4. Chapter 4 Collagen supramolecular structures: Evolution, organization, and biogenesis - p. 55 5. Chapter 5 Collagen suprastructures: The data and the models - p. 77 6. Chapter 6 Selected examples of tissue-level collagen suprastructures: Tendon, bone, and skin - p. 113 7. Chapter 7 Small leucine-rich proteoglycans: The tiny controllers of the extracellular matrix - p. 143 8. Chapter 8 Hyaluronan and hyalectans: The good, the bad, and the ugly - p. 165 9. Chapter 9 Elastic fibers: The near ideal linear springs of the extracellular matrix - p. 193 10. Chapter 10 Modeling maintenance and repair: The matrix loaded - p. 229 11. Chapter 11 Outlook - p. 257 12. Index - p. 259
Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties.
This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki’s book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book.
1. Chapter 1 Introduction to structure-function relationships - p. 1 2. Chapter 2 Extracellular matrix background material: Building blocks, general structure, mechanics, relation to cells, and evolutionary aspects - p. 9 3. Chapter 3 The collagen molecule - p. 29 4. Chapter 4 Collagen supramolecular structures: Evolution, organization, and biogenesis - p. 55 5. Chapter 5 Collagen suprastructures: The data and the models - p. 77 6. Chapter 6 Selected examples of tissue-level collagen suprastructures: Tendon, bone, and skin - p. 113 7. Chapter 7 Small leucine-rich proteoglycans: The tiny controllers of the extracellular matrix - p. 143 8. Chapter 8 Hyaluronan and hyalectans: The good, the bad, and the ugly - p. 165 9. Chapter 9 Elastic fibers: The near ideal linear springs of the extracellular matrix - p. 193 10. Chapter 10 Modeling maintenance and repair: The matrix loaded - p. 229 11. Chapter 11 Outlook - p. 257 12. Index - p. 259
