Studies in Natural Products Chemistry, Volume 90 covers the synthesis, or testing and recording, of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects.
1. Introduction - p. 39 2. Malaria: a constant threat - p. 41 3. Artemisinin: from past to present providing insights in antimalarial drug discovery - p. 48 4. Artemisinin in medicinal chemistry to discover antimalarial drugs: the consolidated SAR studies - p. 52 5. Challenges and opportunities in medicinal chemistry to discover promising antimalarial drugs using the artemisinin scaffold - p. 90 6. Conclusion and future outlook - p. 91 7. Acknowledgments - p. 92 8. Declaration of interest - p. 92 9. Chapter 3. Flavonoids and neurodegeneration: Structure-activity relationship and therapeutic insights - p. 105 10. Introduction - p. 105 11. Flavonoids: Classification and chemical structure - p. 107 12. Mechanisms of neuroprotection by flavonoids - p. 127 13. Structure-activity relationship of flavonoids in neuroprotection - p. 137 14. Therapeutic potential of flavonoids in neurodegenerative diseases - p. 147 15. Metabolism, bioavailability and challenges in flavonoid therapeutic - p. 154 16. Nanotechnology for enhancing flavonoid therapeutics in neurodegeneration - p. 162 17. Future perspectives and clinical translation - p. 172 18. Conclusion - p. 173 19. Abbreviations and their meanings - p. 174 20. Chapter 4. Non-psychoactive phytocannabinoids in the therapy of skin diseases - p. 203 21. Chapter 5. Valerian flavonoids in neuropharmacology: Insights and advances - p. 229 22. Chapter 6. Searching antifungal agents for invasive fungal infection from natural products - p. 279 23. Chapter 7. Therapeutic potential of pectin in cancer - p. 359 24. Chapter 8. Bioactive natural products from seaweeds - p. 385 25. Chapter 9. Inuleae-Plucheinae: Ethnomedicinally applied and chemically diverse Terpenoids with validated bioactivity - p. 405 26. Chapter 10. Resveratrol, the French paradox, and hardaliye: Evaluating a traditional beverage from a health perspective - p. 435 27. Chapter 11. Biotechnologies to improve phenolic biosynthesis in Zea mays L. leaves: Challenges and perspectives - p. 455 28. Index - p. 477
Studies in Natural Products Chemistry, Volume 90 covers the synthesis, or testing and recording, of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects.
1. Introduction - p. 39 2. Malaria: a constant threat - p. 41 3. Artemisinin: from past to present providing insights in antimalarial drug discovery - p. 48 4. Artemisinin in medicinal chemistry to discover antimalarial drugs: the consolidated SAR studies - p. 52 5. Challenges and opportunities in medicinal chemistry to discover promising antimalarial drugs using the artemisinin scaffold - p. 90 6. Conclusion and future outlook - p. 91 7. Acknowledgments - p. 92 8. Declaration of interest - p. 92 9. Chapter 3. Flavonoids and neurodegeneration: Structure-activity relationship and therapeutic insights - p. 105 10. Introduction - p. 105 11. Flavonoids: Classification and chemical structure - p. 107 12. Mechanisms of neuroprotection by flavonoids - p. 127 13. Structure-activity relationship of flavonoids in neuroprotection - p. 137 14. Therapeutic potential of flavonoids in neurodegenerative diseases - p. 147 15. Metabolism, bioavailability and challenges in flavonoid therapeutic - p. 154 16. Nanotechnology for enhancing flavonoid therapeutics in neurodegeneration - p. 162 17. Future perspectives and clinical translation - p. 172 18. Conclusion - p. 173 19. Abbreviations and their meanings - p. 174 20. Chapter 4. Non-psychoactive phytocannabinoids in the therapy of skin diseases - p. 203 21. Chapter 5. Valerian flavonoids in neuropharmacology: Insights and advances - p. 229 22. Chapter 6. Searching antifungal agents for invasive fungal infection from natural products - p. 279 23. Chapter 7. Therapeutic potential of pectin in cancer - p. 359 24. Chapter 8. Bioactive natural products from seaweeds - p. 385 25. Chapter 9. Inuleae-Plucheinae: Ethnomedicinally applied and chemically diverse Terpenoids with validated bioactivity - p. 405 26. Chapter 10. Resveratrol, the French paradox, and hardaliye: Evaluating a traditional beverage from a health perspective - p. 435 27. Chapter 11. Biotechnologies to improve phenolic biosynthesis in Zea mays L. leaves: Challenges and perspectives - p. 455 28. Index - p. 477
