Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.
1. Introduction - p. 167 2. Ethnomedicinal information about Brazilian Hippeastrum - p. 169 3. Chemical composition of Brazilian Hippeastrum species - p. 178 4. Biological activity of Brazilian Hippeastrum species - p. 194 5. Antioxidant activity - p. 197 6. Enzyme inhibition - p. 203 7. Antimicrobial activity - p. 255 8. Cytotoxicity - p. 272 9. Other toxicity assays - p. 276 10. Antiviral activity - p. 278 11. Antiparasitic activity - p. 279 12. Antiinflammatory and wound healing activities - p. 285 13. Central nervous system activity - p. 287 14. Hypoglycemic activity - p. 288 15. Nuclear receptor agonism activity - p. 289 16. Conclusion - p. 291 17. Chapter 6. Natural products with anti-type 2 diabetes mellitus activity and their structure–activity relationships - p. 305 18. Introduction - p. 305 19. Mechanisms of natural products as antidiabetic agents - p. 310 20. α-Glucosidase inhibitor - p. 316 21. α-Amylase inhibitor - p. 355 22. Possessing protein tyrosine phosphatase 1B (PTP1B) inhibitors - p. 364 23. Dipeptidyl peptidase-IV inhibitors - p. 405 24. Sodium–glucose cotransporter 2 inhibitors - p. 412 25. Conclusion and discussion - p. 415 26. Chapter 7. Triterpene glycosides from Cucumaria frondosa, a North Atlantic mass harvesting sea cucumber: A comprehensive structures and biological activities review - p. 431 27. Index - p. 455
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.
1. Introduction - p. 167 2. Ethnomedicinal information about Brazilian Hippeastrum - p. 169 3. Chemical composition of Brazilian Hippeastrum species - p. 178 4. Biological activity of Brazilian Hippeastrum species - p. 194 5. Antioxidant activity - p. 197 6. Enzyme inhibition - p. 203 7. Antimicrobial activity - p. 255 8. Cytotoxicity - p. 272 9. Other toxicity assays - p. 276 10. Antiviral activity - p. 278 11. Antiparasitic activity - p. 279 12. Antiinflammatory and wound healing activities - p. 285 13. Central nervous system activity - p. 287 14. Hypoglycemic activity - p. 288 15. Nuclear receptor agonism activity - p. 289 16. Conclusion - p. 291 17. Chapter 6. Natural products with anti-type 2 diabetes mellitus activity and their structure–activity relationships - p. 305 18. Introduction - p. 305 19. Mechanisms of natural products as antidiabetic agents - p. 310 20. α-Glucosidase inhibitor - p. 316 21. α-Amylase inhibitor - p. 355 22. Possessing protein tyrosine phosphatase 1B (PTP1B) inhibitors - p. 364 23. Dipeptidyl peptidase-IV inhibitors - p. 405 24. Sodium–glucose cotransporter 2 inhibitors - p. 412 25. Conclusion and discussion - p. 415 26. Chapter 7. Triterpene glycosides from Cucumaria frondosa, a North Atlantic mass harvesting sea cucumber: A comprehensive structures and biological activities review - p. 431 27. Index - p. 455
