Techniques for Downstream process for Biologic Drugs and Vaccines provides comprehensive technologies involved in processing postharvest broth to separate the target biological therapeutic products of extracellular or intercellular aspects in nature - to its highest purification form, and to thus make it acceptable to end users. The technologies involved in the post-harvesting of fermented broth are explained in this comprehensive resource in a simplified manner with different case studies to help non-engineering students and scientists easily capture the basic principle of biomass processing technologies and their applications in new projects related to the development and manufacturing of therapeutic bio-products.
As conceptual development of biotechnology has taken new shape and style with the integration of medical sciences, physical science, and engineering, and has thus begun the need for the development of microbial or cell line process technology and application for large-scale isolation and purification of metabolites or vaccines through the fermentation process, this book covers the most important aspects.
1. Techniques for Downstream process for Biologic Drugs and Vaccines - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iv 5. Copyright - p. Page v 6. About the author - p. Page vi 7. List of Illustrations - p. Page vii 8. List of Tables - p. Page viii 9. Chapter 1 : Preharvesting conditions and planning for downstream process - p. Page viii 10. Chapter 2 : Downstream process (harvested broth concentration) phase-I - p. Page 36 11. Chapter 3 : Biomass concentrations phase II - p. Page 62 12. Chapter 4 : Release of intracellular materials phase-III - p. Page 86 13. Chapter 5 : Extraction of product of interest phase IV - p. Page 110 14. Chapter 6 : Viral vectors for vaccine production - p. Page 139 15. Chapter 7 : Quality control - p. Page 170 16. Chapter 8 : Quality by design - p. Page 197 17. Chapter 9 : Biologic drugs: New frontier - p. Page 216 18. Chapter 10 : Biologics market size, shape and trend - p. Page 236 19. Index - p. Page 256
Techniques for Downstream process for Biologic Drugs and Vaccines provides comprehensive technologies involved in processing postharvest broth to separate the target biological therapeutic products of extracellular or intercellular aspects in nature - to its highest purification form, and to thus make it acceptable to end users. The technologies involved in the post-harvesting of fermented broth are explained in this comprehensive resource in a simplified manner with different case studies to help non-engineering students and scientists easily capture the basic principle of biomass processing technologies and their applications in new projects related to the development and manufacturing of therapeutic bio-products.
As conceptual development of biotechnology has taken new shape and style with the integration of medical sciences, physical science, and engineering, and has thus begun the need for the development of microbial or cell line process technology and application for large-scale isolation and purification of metabolites or vaccines through the fermentation process, this book covers the most important aspects.
1. Techniques for Downstream process for Biologic Drugs and Vaccines - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iv 5. Copyright - p. Page v 6. About the author - p. Page vi 7. List of Illustrations - p. Page vii 8. List of Tables - p. Page viii 9. Chapter 1 : Preharvesting conditions and planning for downstream process - p. Page viii 10. Chapter 2 : Downstream process (harvested broth concentration) phase-I - p. Page 36 11. Chapter 3 : Biomass concentrations phase II - p. Page 62 12. Chapter 4 : Release of intracellular materials phase-III - p. Page 86 13. Chapter 5 : Extraction of product of interest phase IV - p. Page 110 14. Chapter 6 : Viral vectors for vaccine production - p. Page 139 15. Chapter 7 : Quality control - p. Page 170 16. Chapter 8 : Quality by design - p. Page 197 17. Chapter 9 : Biologic drugs: New frontier - p. Page 216 18. Chapter 10 : Biologics market size, shape and trend - p. Page 236 19. Index - p. Page 256
