Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes was the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies.Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective field’s present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field.New coverage will include signaling pathways for tendon development, molecular mechanisms of tendinopathy, inflammation contribution to healing and pathology of tendons, tendon aging and degeneration, tendon models, and translational studies for tendon regenerative medicine.
1. Cover image - p. c 2. Title page - p. iii 3. Copyright - p. iv 4. Contents - p. iv 5. Contributors - p. xv 6. Preface - p. xix 7. Section I Biology and physiology of tendons - p. 2 8. Chapter 1 Mechanobiology of embryonic and adult tendons - p. 3 9. Chapter 2 Tendon physiology and mechanical behavior: Structure-function relationships - p. 41 10. Chapter 3 Tendon resident cells—functions and features - p. 85 11. Section II Pathologies and repair of tendons - p. 144 12. Chapter 4 The tendinopathy triad—mechanical stress, inflammation, and vascularity - p. 145 13. Chapter 5 Medical considerations in tendinopathy - p. 181 14. Chapter 6 Tendinopathy II: Etiology, pathology, and healing of tendon injury and disease - p. 219 15. Chapter 7 Biomechanical, biological, and molecular mechanisms of tendon homeostasis, adaptation, repair, and disease - p. 265 16. Chapter 8 Tendon aging and degeneration - p. 327 17. Chapter 9 The veterinarian perspective: Comparative anatomy, equine models and in vivo bioengineering of tendons - p. 359 18. Section III Tendon tissue engineering and regenerative medicine approaches - p. 382 19. Chapter 10 Cell-based approaches for tendon regeneration - p. 383 20. Chapter 11 Engineering anisotropic structures for tendon repair and regeneration - p. 413 21. Chapter 12 Fabrication of hierarchical and biomimetic fibrous structures to support the regeneration of tendon tissues – from scaffolds to 3D bioprinted constructs - p. 431 22. Chapter 13 Multifactorial tendon tissue engineering strategies - p. 461 23. Section IV Translating tendon regenerative medicine strategies - p. 478 24. Chapter 14 Translation of new tendinopathy therapies: Are we there yet? - p. 479 25. Chapter 15 Gene transfer to tendon - p. 521 26. Index - p. 537
Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes was the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies.Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective field’s present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field.New coverage will include signaling pathways for tendon development, molecular mechanisms of tendinopathy, inflammation contribution to healing and pathology of tendons, tendon aging and degeneration, tendon models, and translational studies for tendon regenerative medicine.
1. Cover image - p. c 2. Title page - p. iii 3. Copyright - p. iv 4. Contents - p. iv 5. Contributors - p. xv 6. Preface - p. xix 7. Section I Biology and physiology of tendons - p. 2 8. Chapter 1 Mechanobiology of embryonic and adult tendons - p. 3 9. Chapter 2 Tendon physiology and mechanical behavior: Structure-function relationships - p. 41 10. Chapter 3 Tendon resident cells—functions and features - p. 85 11. Section II Pathologies and repair of tendons - p. 144 12. Chapter 4 The tendinopathy triad—mechanical stress, inflammation, and vascularity - p. 145 13. Chapter 5 Medical considerations in tendinopathy - p. 181 14. Chapter 6 Tendinopathy II: Etiology, pathology, and healing of tendon injury and disease - p. 219 15. Chapter 7 Biomechanical, biological, and molecular mechanisms of tendon homeostasis, adaptation, repair, and disease - p. 265 16. Chapter 8 Tendon aging and degeneration - p. 327 17. Chapter 9 The veterinarian perspective: Comparative anatomy, equine models and in vivo bioengineering of tendons - p. 359 18. Section III Tendon tissue engineering and regenerative medicine approaches - p. 382 19. Chapter 10 Cell-based approaches for tendon regeneration - p. 383 20. Chapter 11 Engineering anisotropic structures for tendon repair and regeneration - p. 413 21. Chapter 12 Fabrication of hierarchical and biomimetic fibrous structures to support the regeneration of tendon tissues – from scaffolds to 3D bioprinted constructs - p. 431 22. Chapter 13 Multifactorial tendon tissue engineering strategies - p. 461 23. Section IV Translating tendon regenerative medicine strategies - p. 478 24. Chapter 14 Translation of new tendinopathy therapies: Are we there yet? - p. 479 25. Chapter 15 Gene transfer to tendon - p. 521 26. Index - p. 537
