Multidisciplinary in scope and fully up to date with the latest advances in medical oncology and more, Bland and Copeland's The Breast, 6th Edition, covers every clinically relevant aspect of the field: cancer, congenital abnormalities, hormones, reconstruction, anatomy and physiology, benign breast disease, and more. In a practical, easy-to-use format ideal for today’s busy practitioners, this truly comprehensive resource is ideal for surgical oncologists, breast surgeons, general surgeons, medical oncologists, and others who need to stay informed of the latest innovations in this complex and fast-moving area.
Offers the most comprehensive, up-to-date information on the diagnosis and management of, and rehabilitation following, treatment for benign and malignant diseases of the breast.
Updates include an extensively updated oncoplastic section and extended medical and radiation oncology sections.
Delivers step-by-step clinical guidance highlighted by hundreds of superb illustrations that depict relevant anatomy and pathology, as well as medical and surgical procedures.
Reflects the collaborative nature of diagnosis and treatment among radiologists, pathologists, breast and plastic surgeons, radiation and medical oncologists, geneticists and other health care professionals who contribute to the management of patients with breast disease.
Includes access to procedural videos that provide expert visual guidance on how to execute key steps and techniques.
1. Instructions for Online Access - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Any screen, Any time, Anywhere - p. iii 6. Copyright - p. iv 7. Dedicated - p. vi 8. Contributors - p. vii 9. Preface - p. xv 10. Acknowledgments - p. xvii 11. Video Contents - p. xxiii 12. Section I: History of the Therapy of Breast Cancer - p. xxiv 13. 1. The History of the Therapy for Breast Cancer - p. 1 14. Non-Print Item Abstract - p. 1 15. Ancient Civilizations - p. 1 16. Cultural and Religious Influences of the 2nd to 15th Centuries - p. 8 17. Scientific Progress of the Renaissance Period (14th–16th Century) - p. 10 18. 18th Century - p. 12 19. Uniform Withdrawal of Breast Therapy (Late 18th–Early 19th Centuries) - p. 15 20. 19th Century - p. 16 21. 20th Century Progress for Breast Cancer: An Appreciation for Evolving Concepts Formetastases - p. 23 22. Origins of Adjuvant Breast Cancer Therapy - p. 26 23. 20th and 21st Century Discovery with Integration of Pathology, Genomics, Immunochemistry: Evolution of the Breastcancer Subtypes - p. 37 24. Selected References - p. 41 25. References - p. 41 26. 2. History of Surgical Clinical Trials and Cooperative Group Trials - p. 42 27. 3. Important Trials of the Last Decade - p. 50 28. Section II: Anatomy and Physiology of the Normal and Lactating Breast - p. 61 29. 4. Anatomy of the Breast, Axilla, Chest Wall, and Related Metastatic Sites - p. 62 30. 5. Breast Physiology: Normal and Abnormal Development and Function - p. 78 31. 6. Discharges and Secretions of the Nipple - p. 97 32. Section III: Natural History, Epidemiology, Genetics, and Syndromes of the Breast - p. 118 33. 7. Epidemiology of Breast Cancer - p. 119 34. 8. Carcinogenesis of Breast Cancer - p. 128 35. 9. Risk Reduction for Developing Breast Cancer - p. 133 36. 10. Breast Cancer Genetics: Syndromes, Genes, Pathology, Counseling, Testing, and Treatment - p. 149 37. Section IV: Screening and Diagnosis of the Breast Patient - p. 160 38. 11. Clinical Encounter With the Patient - p. 161 39. 12. Breast Cancer Screening - p. 167 40. 13. Breast Cancer Diagnosis and Techniques for Biopsy - p. 184 41. Section V: Benign and Premalignant Lesions - p. 196 42. 14. Etiology and Management of Benign Breast Disease - p. 197 43. 15. Mastitis and Breast Abscess - p. 212 44. 16. Gynecomastia - p. 223 45. 17. High-Risk and Premalignant Lesions of the Breast - p. 233 46. Section VI: Pathology of Malignant Lesions - p. 239 47. 18. Disorders of the Skin - p. 240 48. 19. Ductal Carcinoma In Situ - p. 257 49. 20. Infiltrating Carcinomas of the Breast - p. 269 50. 21. Biomarkers - p. 281 51. 22. Fibroepithelial Tumors and Hamartomas - p. 292 52. 23. Lymphomas of the Breast - p. 306 53. 24. Mesenchymal Neoplasms of the Breast - p. 313 54. 25. Unusual and Rare Tumors of the Breast - p. 319 55. Section VII: Prognostic Factors for Breast Cancer - p. 326 56. 26. Clinical Prognosis and Staging of Breast Cancer - p. 327 57. 27. Molecular Biomarkers for Breast Cancer Prognosis - p. 336 58. 28. Examining Domestic and International Disparities in Breast Cancer Screening, Treatment, and Outcomes - p. 350 59. Section VIII: Surgical Techniques of the Breast - p. 354 60. 29. Management of Lobular Neoplasia and Ductal Carcinoma in Situ - p. 355 61. 30. General Principles of Mastectomy: From Halsted Radical Mastectomy and Modified Radical Mastectomy to Total (Simple) Mastectomy - p. 368 62. 31. Breast Conservation Therapy for Invasive Breast Cancer - p. 389 63. 32. Intraoperative Evaluation of Surgical Margins in Breast-Conserving Therapy - p. 404 64. 33. Lymphatic Mapping and Sentinel Lymphadenectomy for Breast Cancer - p. 408 65. 34. Lymphatic Mapping and Targeted Axillary Dissection Procedure After Neoadjuvant Chemotherapy - p. 434 66. 35. Therapeutic Value of Axillary Node Dissection - p. 439 67. 36. Lymphedema Prevention and Treatment: Axillary Reverse Mapping, LYMPHA, Lymph Node Transfer, and Other Surgical Techniques - p. 452 68. 37. Wound Care and Complications of Mastectomy - p. 469 69. 38. Pain Management of the Breast Cancer Surgery Patient - p. 475 70. Section IX: Oncoplastic Breast Surgery and Reconstruction - p. 479 71. 39. Optimizing Cosmetic Outcomes for Breast Surgery - p. 480 72. 40. Upper Hemisphere Oncoplastic Surgery - p. 484 73. 41. Oncoplastic Techniques for the Lower Hemisphere of the Breast - p. 495 74. 42. Oncoplastic Breast Reconstruction: Extreme Oncoplasty and Split Reduction Techniques - p. 502 75. 43. Nipple Skin-Sparing Mastectomy - p. 509 76. 44. Breast Reconstruction - p. 515 77. Section X: Adjuvant Therapy for Stages 0, I, and II Breast Cancer - p. 529 78. 45. Radiotherapy and Regional Nodes - p. 530 79. 46. Postmastectomy Radiation Therapy - p. 539 80. 47. Breast-Conserving Therapy for Invasive Breast Cancers - p. 550 81. 48. Partial Breast Irradiation: Accelerated and Intraoperative - p. 564 82. 49. Radiation Complications and Their Management - p. 573 83. 50. Radiation Therapy for Locally Advanced Breast Cancer: Historical Review to Current Approaches - p. 583 84. 51. Systemic Therapy of Hormone-Sensitive HER2-Negative Breast Cancer: Adjuvant and Neoadjuvant - p. 592 85. 52. Adjuvant and Neoadjuvant Systemic Therapies for Triple-Negative Breast Cancer - p. 611 86. 53. Adjuvant and Neoadjuvant HER2 Therapy - p. 620 87. Section XI: Management of Advanced Local, Regional, and Systemic Disease - p. 625 88. 54. Surgical Procedures for Advanced Local and Regional Malignancies of the Breast - p. 627 89. 55. Management of the Intact Breast Primary in the Setting of Metastatic Disease - p. 641 90. 56. Locoregional Recurrence of Breast Cancer - p. 651 91. 57. Locally Advanced and Inflammatory Breast Cancer - p. 659 92. 58. Clinical Implications of Occult Systemic Micrometastatic Breast Cancer - p. 669 93. 59. Management of Breast Cancer Solitary Metastases - p. 674 94. 60. Management of Bone Metastases in Breast Cancer - p. 681 95. 61. Chemotherapy and HER2-Directed Therapy for Metastatic Breast Cancer - p. 688 96. 62. Endocrine Therapy for Late-Stage and Metastatic Breast Cancer - p. 704 97. 63. Immunological Approaches to Breast Cancer Therapy - p. 717 98. 64. Diagnosis and Management of Pleural Metastases and Malignant Effusion in Breast Cancer - p. 728 99. 65. Management of Central Nervous System Metastases in Breast Cancer - p. 736 100. Section XII: Special Presentations of Breast Cancer - p. 753 101. 66. Bilateral Breast Cancer - p. 754 102. 67. Male Breast Cancer - p. 760 103. 68. Local Recurrence, the Augmented Breast, and the Contralateral Breast - p. 764 104. 69. Carcinoma of the Breast in Pregnancy and Lactation - p. 784 105. 70. Unknown Primary Presenting With Axillary Lymphadenopathy - p. 792 106. Section XIII: Survivorship, Follow-Up Care, and Rehabilitation of the Breast Cancer Patient - p. 795 107. 71. Creating a Breast Cancer Survivorship Plan and Clinic - p. 796 108. 72. General Considerations for Follow-Up - p. 806 109. 73. Bone-Modifying Agents in Early Breast Cancer - p. 818 110. 74. Fertility Preservation for Women With Breast Cancer - p. 822 111. 75. Quality Measures and Performance Improvement for Breast Cancer Surgery - p. 827 112. 76. Lymphedema in the Postsurgical Patient: Pathophysiology and Nonoperative Management - p. 841 113. 77. Management of Menopause in Breast Cancer Survivors - p. 855 114. 78. Rehabilitation - p. 864 115. 79. Psychosocial Consequences and Lifestyle Interventions - p. 873 116. Online Appendix - p. 881 117. Index - p. 883 118. Confidence is ClinicalKey - p. 915
Multidisciplinary in scope and fully up to date with the latest advances in medical oncology and more, Bland and Copeland's The Breast, 6th Edition, covers every clinically relevant aspect of the field: cancer, congenital abnormalities, hormones, reconstruction, anatomy and physiology, benign breast disease, and more. In a practical, easy-to-use format ideal for today’s busy practitioners, this truly comprehensive resource is ideal for surgical oncologists, breast surgeons, general surgeons, medical oncologists, and others who need to stay informed of the latest innovations in this complex and fast-moving area.
Offers the most comprehensive, up-to-date information on the diagnosis and management of, and rehabilitation following, treatment for benign and malignant diseases of the breast.
Updates include an extensively updated oncoplastic section and extended medical and radiation oncology sections.
Delivers step-by-step clinical guidance highlighted by hundreds of superb illustrations that depict relevant anatomy and pathology, as well as medical and surgical procedures.
Reflects the collaborative nature of diagnosis and treatment among radiologists, pathologists, breast and plastic surgeons, radiation and medical oncologists, geneticists and other health care professionals who contribute to the management of patients with breast disease.
Includes access to procedural videos that provide expert visual guidance on how to execute key steps and techniques.
1. Instructions for Online Access - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Any screen, Any time, Anywhere - p. iii 6. Copyright - p. iv 7. Dedicated - p. vi 8. Contributors - p. vii 9. Preface - p. xv 10. Acknowledgments - p. xvii 11. Video Contents - p. xxiii 12. Section I: History of the Therapy of Breast Cancer - p. xxiv 13. 1. The History of the Therapy for Breast Cancer - p. 1 14. Non-Print Item Abstract - p. 1 15. Ancient Civilizations - p. 1 16. Cultural and Religious Influences of the 2nd to 15th Centuries - p. 8 17. Scientific Progress of the Renaissance Period (14th–16th Century) - p. 10 18. 18th Century - p. 12 19. Uniform Withdrawal of Breast Therapy (Late 18th–Early 19th Centuries) - p. 15 20. 19th Century - p. 16 21. 20th Century Progress for Breast Cancer: An Appreciation for Evolving Concepts Formetastases - p. 23 22. Origins of Adjuvant Breast Cancer Therapy - p. 26 23. 20th and 21st Century Discovery with Integration of Pathology, Genomics, Immunochemistry: Evolution of the Breastcancer Subtypes - p. 37 24. Selected References - p. 41 25. References - p. 41 26. 2. History of Surgical Clinical Trials and Cooperative Group Trials - p. 42 27. 3. Important Trials of the Last Decade - p. 50 28. Section II: Anatomy and Physiology of the Normal and Lactating Breast - p. 61 29. 4. Anatomy of the Breast, Axilla, Chest Wall, and Related Metastatic Sites - p. 62 30. 5. Breast Physiology: Normal and Abnormal Development and Function - p. 78 31. 6. Discharges and Secretions of the Nipple - p. 97 32. Section III: Natural History, Epidemiology, Genetics, and Syndromes of the Breast - p. 118 33. 7. Epidemiology of Breast Cancer - p. 119 34. 8. Carcinogenesis of Breast Cancer - p. 128 35. 9. Risk Reduction for Developing Breast Cancer - p. 133 36. 10. Breast Cancer Genetics: Syndromes, Genes, Pathology, Counseling, Testing, and Treatment - p. 149 37. Section IV: Screening and Diagnosis of the Breast Patient - p. 160 38. 11. Clinical Encounter With the Patient - p. 161 39. 12. Breast Cancer Screening - p. 167 40. 13. Breast Cancer Diagnosis and Techniques for Biopsy - p. 184 41. Section V: Benign and Premalignant Lesions - p. 196 42. 14. Etiology and Management of Benign Breast Disease - p. 197 43. 15. Mastitis and Breast Abscess - p. 212 44. 16. Gynecomastia - p. 223 45. 17. High-Risk and Premalignant Lesions of the Breast - p. 233 46. Section VI: Pathology of Malignant Lesions - p. 239 47. 18. Disorders of the Skin - p. 240 48. 19. Ductal Carcinoma In Situ - p. 257 49. 20. Infiltrating Carcinomas of the Breast - p. 269 50. 21. Biomarkers - p. 281 51. 22. Fibroepithelial Tumors and Hamartomas - p. 292 52. 23. Lymphomas of the Breast - p. 306 53. 24. Mesenchymal Neoplasms of the Breast - p. 313 54. 25. Unusual and Rare Tumors of the Breast - p. 319 55. Section VII: Prognostic Factors for Breast Cancer - p. 326 56. 26. Clinical Prognosis and Staging of Breast Cancer - p. 327 57. 27. Molecular Biomarkers for Breast Cancer Prognosis - p. 336 58. 28. Examining Domestic and International Disparities in Breast Cancer Screening, Treatment, and Outcomes - p. 350 59. Section VIII: Surgical Techniques of the Breast - p. 354 60. 29. Management of Lobular Neoplasia and Ductal Carcinoma in Situ - p. 355 61. 30. General Principles of Mastectomy: From Halsted Radical Mastectomy and Modified Radical Mastectomy to Total (Simple) Mastectomy - p. 368 62. 31. Breast Conservation Therapy for Invasive Breast Cancer - p. 389 63. 32. Intraoperative Evaluation of Surgical Margins in Breast-Conserving Therapy - p. 404 64. 33. Lymphatic Mapping and Sentinel Lymphadenectomy for Breast Cancer - p. 408 65. 34. Lymphatic Mapping and Targeted Axillary Dissection Procedure After Neoadjuvant Chemotherapy - p. 434 66. 35. Therapeutic Value of Axillary Node Dissection - p. 439 67. 36. Lymphedema Prevention and Treatment: Axillary Reverse Mapping, LYMPHA, Lymph Node Transfer, and Other Surgical Techniques - p. 452 68. 37. Wound Care and Complications of Mastectomy - p. 469 69. 38. Pain Management of the Breast Cancer Surgery Patient - p. 475 70. Section IX: Oncoplastic Breast Surgery and Reconstruction - p. 479 71. 39. Optimizing Cosmetic Outcomes for Breast Surgery - p. 480 72. 40. Upper Hemisphere Oncoplastic Surgery - p. 484 73. 41. Oncoplastic Techniques for the Lower Hemisphere of the Breast - p. 495 74. 42. Oncoplastic Breast Reconstruction: Extreme Oncoplasty and Split Reduction Techniques - p. 502 75. 43. Nipple Skin-Sparing Mastectomy - p. 509 76. 44. Breast Reconstruction - p. 515 77. Section X: Adjuvant Therapy for Stages 0, I, and II Breast Cancer - p. 529 78. 45. Radiotherapy and Regional Nodes - p. 530 79. 46. Postmastectomy Radiation Therapy - p. 539 80. 47. Breast-Conserving Therapy for Invasive Breast Cancers - p. 550 81. 48. Partial Breast Irradiation: Accelerated and Intraoperative - p. 564 82. 49. Radiation Complications and Their Management - p. 573 83. 50. Radiation Therapy for Locally Advanced Breast Cancer: Historical Review to Current Approaches - p. 583 84. 51. Systemic Therapy of Hormone-Sensitive HER2-Negative Breast Cancer: Adjuvant and Neoadjuvant - p. 592 85. 52. Adjuvant and Neoadjuvant Systemic Therapies for Triple-Negative Breast Cancer - p. 611 86. 53. Adjuvant and Neoadjuvant HER2 Therapy - p. 620 87. Section XI: Management of Advanced Local, Regional, and Systemic Disease - p. 625 88. 54. Surgical Procedures for Advanced Local and Regional Malignancies of the Breast - p. 627 89. 55. Management of the Intact Breast Primary in the Setting of Metastatic Disease - p. 641 90. 56. Locoregional Recurrence of Breast Cancer - p. 651 91. 57. Locally Advanced and Inflammatory Breast Cancer - p. 659 92. 58. Clinical Implications of Occult Systemic Micrometastatic Breast Cancer - p. 669 93. 59. Management of Breast Cancer Solitary Metastases - p. 674 94. 60. Management of Bone Metastases in Breast Cancer - p. 681 95. 61. Chemotherapy and HER2-Directed Therapy for Metastatic Breast Cancer - p. 688 96. 62. Endocrine Therapy for Late-Stage and Metastatic Breast Cancer - p. 704 97. 63. Immunological Approaches to Breast Cancer Therapy - p. 717 98. 64. Diagnosis and Management of Pleural Metastases and Malignant Effusion in Breast Cancer - p. 728 99. 65. Management of Central Nervous System Metastases in Breast Cancer - p. 736 100. Section XII: Special Presentations of Breast Cancer - p. 753 101. 66. Bilateral Breast Cancer - p. 754 102. 67. Male Breast Cancer - p. 760 103. 68. Local Recurrence, the Augmented Breast, and the Contralateral Breast - p. 764 104. 69. Carcinoma of the Breast in Pregnancy and Lactation - p. 784 105. 70. Unknown Primary Presenting With Axillary Lymphadenopathy - p. 792 106. Section XIII: Survivorship, Follow-Up Care, and Rehabilitation of the Breast Cancer Patient - p. 795 107. 71. Creating a Breast Cancer Survivorship Plan and Clinic - p. 796 108. 72. General Considerations for Follow-Up - p. 806 109. 73. Bone-Modifying Agents in Early Breast Cancer - p. 818 110. 74. Fertility Preservation for Women With Breast Cancer - p. 822 111. 75. Quality Measures and Performance Improvement for Breast Cancer Surgery - p. 827 112. 76. Lymphedema in the Postsurgical Patient: Pathophysiology and Nonoperative Management - p. 841 113. 77. Management of Menopause in Breast Cancer Survivors - p. 855 114. 78. Rehabilitation - p. 864 115. 79. Psychosocial Consequences and Lifestyle Interventions - p. 873 116. Online Appendix - p. 881 117. Index - p. 883 118. Confidence is ClinicalKey - p. 915
