The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders: Experimental Approaches to Clinical Issues focuses on how pre-clinical investigations are addressing the clinical issues surrounding the involvement of the cerebral cortex in selected conditions of the nervous system, including Alzheimer’s Disease, Parkinson’s, addiction, and cardiovascular dysregulation.
Each chapter is written by an expert in his/her field who provides a comprehensive review of the clinical manifestations of cortical involvement and experimental techniques currently available to tackle cortical issues in disease. Thus, this present title provides a link between cortical clinical problems and investigational approaches to help foster future research with high translational value.
1. Introduction - p. xv 2. Part I. Introductory Chapters - p. xix 3. Chapter 1. Anatomy of the Cerebral Cortex - p. 3 4. Chapter 2. Cortical Plasticity in Response to Injury and Disease - p. 37 5. Chapter 3. Imaging Approaches to Cerebral Cortex Pathology - p. 57 6. Part II. The Cerebral Cortex in Neurodegenerative Disorders - p. 80 7. Chapter 4. Alzheimer’s Disease - p. 83 8. Clinical Manifestations - p. 83 9. Cerebral Cortex Pattern of Alzheimer’s Disease Progression - p. 89 10. Imaging Alzheimer’s Disease Pathology - p. 97 11. Alzheimer’s Disease Therapeutics - p. 99 12. Future Directions - p. 101 13. Chapter 5. Vascular Dementia - p. 119 14. Chapter 6. Frontotemporal Dementia - p. 141 15. Introduction - p. 141 16. Clinical Manifestations - p. 141 17. Imaging Studies of Frontotemporal Dementia - p. 146 18. Frontotemporal Dementia Genetics - p. 151 19. Experimental Models - p. 153 20. Therapeutic Approaches - p. 157 21. Future Directions - p. 160 22. Chapter 7. Parkinson’s Disease and the Cerebral Cortex - p. 177 23. Chapter 8. Huntington Disease - p. 195 24. Chapter 9. Cortical Manifestations in Amyotrophic Lateral Sclerosis - p. 223 25. Chapter 10. Cortical Involvement in Multiple Sclerosis - p. 243 26. Part III. The Cerebral Cortex in Neuropsychiatric Disorders - p. 273 27. Chapter 11. Prefrontal Cortical Abnormalities in Cognitive Deficits of Schizophrenia - p. 277 28. Chapter 12. Role of the Prefrontal Cortex in Addictive Disorders - p. 289 29. List of Acronyms and Abbreviations - p. 311 30. Index - p. 315
The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders: Experimental Approaches to Clinical Issues focuses on how pre-clinical investigations are addressing the clinical issues surrounding the involvement of the cerebral cortex in selected conditions of the nervous system, including Alzheimer’s Disease, Parkinson’s, addiction, and cardiovascular dysregulation.
Each chapter is written by an expert in his/her field who provides a comprehensive review of the clinical manifestations of cortical involvement and experimental techniques currently available to tackle cortical issues in disease. Thus, this present title provides a link between cortical clinical problems and investigational approaches to help foster future research with high translational value.
1. Introduction - p. xv 2. Part I. Introductory Chapters - p. xix 3. Chapter 1. Anatomy of the Cerebral Cortex - p. 3 4. Chapter 2. Cortical Plasticity in Response to Injury and Disease - p. 37 5. Chapter 3. Imaging Approaches to Cerebral Cortex Pathology - p. 57 6. Part II. The Cerebral Cortex in Neurodegenerative Disorders - p. 80 7. Chapter 4. Alzheimer’s Disease - p. 83 8. Clinical Manifestations - p. 83 9. Cerebral Cortex Pattern of Alzheimer’s Disease Progression - p. 89 10. Imaging Alzheimer’s Disease Pathology - p. 97 11. Alzheimer’s Disease Therapeutics - p. 99 12. Future Directions - p. 101 13. Chapter 5. Vascular Dementia - p. 119 14. Chapter 6. Frontotemporal Dementia - p. 141 15. Introduction - p. 141 16. Clinical Manifestations - p. 141 17. Imaging Studies of Frontotemporal Dementia - p. 146 18. Frontotemporal Dementia Genetics - p. 151 19. Experimental Models - p. 153 20. Therapeutic Approaches - p. 157 21. Future Directions - p. 160 22. Chapter 7. Parkinson’s Disease and the Cerebral Cortex - p. 177 23. Chapter 8. Huntington Disease - p. 195 24. Chapter 9. Cortical Manifestations in Amyotrophic Lateral Sclerosis - p. 223 25. Chapter 10. Cortical Involvement in Multiple Sclerosis - p. 243 26. Part III. The Cerebral Cortex in Neuropsychiatric Disorders - p. 273 27. Chapter 11. Prefrontal Cortical Abnormalities in Cognitive Deficits of Schizophrenia - p. 277 28. Chapter 12. Role of the Prefrontal Cortex in Addictive Disorders - p. 289 29. List of Acronyms and Abbreviations - p. 311 30. Index - p. 315
