Annual Report on Medicinal Chemistry series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_ix 6. Preface - p. page_xi 7. Chapter One: Kinetic mechanisms of covalent inhibition - p. page_1 8. Chapter Two: Covalent drugs in development for immune-mediated diseases - p. page_33 9. Chapter Three: Chemistry perspectives of reversible covalent drugs - p. page_75 10. Chapter Four: Design of next-generation covalent inhibitors: Targeting residues beyond cysteine - p. page_95 11. Chapter Five: Boron and covalent inhibition - p. page_135 12. Chapter Six: Measuring and predicting warhead and residue reactivity - p. page_203 13. Chapter Seven: Computational support of structure-based targeted covalent inhibitor design - p. page_229 14. Chapter Eight: Covalent fragment screening - p. page_243 15. Chapter Nine: The future of covalent inhibition - p. page_267
Annual Report on Medicinal Chemistry series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_ix 6. Preface - p. page_xi 7. Chapter One: Kinetic mechanisms of covalent inhibition - p. page_1 8. Chapter Two: Covalent drugs in development for immune-mediated diseases - p. page_33 9. Chapter Three: Chemistry perspectives of reversible covalent drugs - p. page_75 10. Chapter Four: Design of next-generation covalent inhibitors: Targeting residues beyond cysteine - p. page_95 11. Chapter Five: Boron and covalent inhibition - p. page_135 12. Chapter Six: Measuring and predicting warhead and residue reactivity - p. page_203 13. Chapter Seven: Computational support of structure-based targeted covalent inhibitor design - p. page_229 14. Chapter Eight: Covalent fragment screening - p. page_243 15. Chapter Nine: The future of covalent inhibition - p. page_267
