The Eye: Basic Sciences in Practice provides highly accessible, concise coverage of all the essential basic science required by today’s ophthalmologists and optometrists in training. It is also essential reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area.
This new fourth edition has now been fully revised and updated in line with current curricula, key research developments and clinical best practice. It succinctly incorporates the massive strides being made by genetics and functional genomics based on the Human Genome Project, the new understanding of how the microbiome affects all aspects of immunology, the remarkable progress in imaging technology now applied to anatomy and neurophysiology, as well as exciting new molecular and other diagnostic methodologies now being used in microbiology and pathology. All this and more collectively brings a wealth of new knowledge to students and practitioners in the fields of ophthalmology and visual science.
1. Introduction - p. 157 2. Cells and tissues - p. 159.e1 3. Biochemical pathways that affect ocular function - p. 188.e1 4. The ocular surface - p. 198 5. Cornea and sclera - p. 202.e1 6. Uveal tract - p. 216 7. Aqueous humour dynamics - p. 222 8. The lens - p. 228 9. The vitreous - p. 240 10. The retina - p. 242 11. The chemistry of the visual response - p. 258 12. Conclusion - p. 268 13. Further Reading - p. 268 14. Chapter 5 Physiology of vision and the visual system - p. 269 15. Introduction - p. 269 16. Light detection and dark adaptation - p. 273 17. Visual acuity and contrast sensitivity - p. 279.e3 18. Electrophysiology of the visual system - p. 287 19. Colour vision - p. 302 20. Visual perception - p. 308 21. Division of labour in the visual system: parcellation and the human connectome - p. 320 22. Physiology of ocular movement - p. 325.e1 23. Conclusion - p. 336 24. Further Reading - p. 337 25. Chapter 6 General and ocular pharmacology - p. 338 26. Chapter 7 Immunology - p. 370 27. Introduction - p. 370 28. Overview of the immune system - p. 370 29. Cells and molecules of the immune system - p. 373 30. Initial response of the host to injury (the innate immune response) - p. 382 31. Development of adaptive immunity and immunological memory - p. 395 32. Effector mechanisms - p. 396 33. Organization of the immune system - p. 412 34. Antigen recognition - p. 421 35. The major histocompatibility system - p. 424 36. T-cell activation - p. 427 37. B-cell activation - p. 437 38. Immunological tolerance and autoimmunity - p. 439 39. Allergy and immediate hypersensitivity - p. 445 40. Organ and tissue transplantation - p. 450 41. Tumours induce immune responses - p. 451 42. The eye and the immune system - p. 453 43. Conclusion - p. 461 44. Further Reading - p. 461 45. Chapter 8 Microbial infections of the eye - p. 462 46. Chapter 9 Pathology - p. 486 47. Index - p. 539
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The Eye: Basic Sciences in Practice provides highly accessible, concise coverage of all the essential basic science required by today’s ophthalmologists and optometrists in training. It is also essential reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area.
This new fourth edition has now been fully revised and updated in line with current curricula, key research developments and clinical best practice. It succinctly incorporates the massive strides being made by genetics and functional genomics based on the Human Genome Project, the new understanding of how the microbiome affects all aspects of immunology, the remarkable progress in imaging technology now applied to anatomy and neurophysiology, as well as exciting new molecular and other diagnostic methodologies now being used in microbiology and pathology. All this and more collectively brings a wealth of new knowledge to students and practitioners in the fields of ophthalmology and visual science.
1. Introduction - p. 157 2. Cells and tissues - p. 159.e1 3. Biochemical pathways that affect ocular function - p. 188.e1 4. The ocular surface - p. 198 5. Cornea and sclera - p. 202.e1 6. Uveal tract - p. 216 7. Aqueous humour dynamics - p. 222 8. The lens - p. 228 9. The vitreous - p. 240 10. The retina - p. 242 11. The chemistry of the visual response - p. 258 12. Conclusion - p. 268 13. Further Reading - p. 268 14. Chapter 5 Physiology of vision and the visual system - p. 269 15. Introduction - p. 269 16. Light detection and dark adaptation - p. 273 17. Visual acuity and contrast sensitivity - p. 279.e3 18. Electrophysiology of the visual system - p. 287 19. Colour vision - p. 302 20. Visual perception - p. 308 21. Division of labour in the visual system: parcellation and the human connectome - p. 320 22. Physiology of ocular movement - p. 325.e1 23. Conclusion - p. 336 24. Further Reading - p. 337 25. Chapter 6 General and ocular pharmacology - p. 338 26. Chapter 7 Immunology - p. 370 27. Introduction - p. 370 28. Overview of the immune system - p. 370 29. Cells and molecules of the immune system - p. 373 30. Initial response of the host to injury (the innate immune response) - p. 382 31. Development of adaptive immunity and immunological memory - p. 395 32. Effector mechanisms - p. 396 33. Organization of the immune system - p. 412 34. Antigen recognition - p. 421 35. The major histocompatibility system - p. 424 36. T-cell activation - p. 427 37. B-cell activation - p. 437 38. Immunological tolerance and autoimmunity - p. 439 39. Allergy and immediate hypersensitivity - p. 445 40. Organ and tissue transplantation - p. 450 41. Tumours induce immune responses - p. 451 42. The eye and the immune system - p. 453 43. Conclusion - p. 461 44. Further Reading - p. 461 45. Chapter 8 Microbial infections of the eye - p. 462 46. Chapter 9 Pathology - p. 486 47. Index - p. 539
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