The Handbook of Dopamine captures current understanding of dopamine biology in the brain, including anatomical organization of dopamine neurons, their molecular and genetic diversity, synaptic and circuit connectivity, receptor function and signalling, through to diverse roles in behaviors and finally, dysfunction in disease. This volume compiles a comprehensive set of perspectives from a large number of leading scientists working in dopamine research. The volume describes the current state-of-the-field, summarizing knowledge that has been transformed in the last decade through the advent and application of sophisticated new technologies.
1. The Handbook of Dopamine - p. i 2. Cover image - p. i 3. Title page - p. i 4. Table of Contents - p. i 5. Copyright - p. iv 6. Contributors - p. xi 7. Preface - p. xv 8. A perspective on dopamine - p. xvii 9. Section 1: Molecular neuroanatomy of dopamine neurons: Development, diversity, and connectivity - p. xxxi 10. Chapter 1 The dopamine system from an evolutionary perspective - p. 3 11. Chapter 2 Molecular heterogeneity of midbrain dopamine neurons - p. 13 12. Chapter 3 Building an action circuit with nigrostriatal dopaminergic neurons and striatonigral neurons - p. 25 13. Chapter 4 Anatomy of dopamine neuron projections: Axonal arbors, varicosities, and synapses - p. 37 14. Chapter 5 Dopamine neuron connectomes: Inputs and outputs - p. 49 15. Section 2: Dopamine neuron physiology and dopamine release regulation - p. 62 16. Chapter 6 Electrical patterns of activity in dopamine midbrain neurons in vivo - p. 65 17. Chapter 7 Computational modeling of midbrain dopamine neurons - p. 77 18. Chapter 8 Axonal dopamine release: Molecular mechanisms - p. 93 19. Chapter 9 Somatodendritic dopamine release - p. 101 20. Chapter 10 Axonal regulation of dopamine transmission by striatal neuromodulators - p. 115 21. Chapter 11 Dopamine transporters and the nanoscale organization of the dopamine axon - p. 129 22. Chapter 12 Beyond dopamine: Cotransmission by dopamine neurons - p. 141 23. Section 3: Dopamine signalling: Receptors, postsynaptic integration and plasticity - p. 151 24. Chapter 13 Unveiling activation mechanisms and intrinsic divergence of dopamine receptors based on experimentally determined structures - p. 155 25. Chapter 14 Dopamine receptor drugs and their applications - p. 171 26. Chapter 15 Postsynaptic integration and plasticity in the striatum - p. 187 27. Chapter 16 Dopamine signaling roles in the extrastriatal basal ganglia - p. 201 28. Chapter 17 Postsynaptic integration and plasticity in the prefrontal cortex - p. 213 29. Section 4: Dopamine mechanisms of learning and reinforcement - p. 222 30. Chapter 18 The dopamine reward prediction error signal - p. 223 31. Chapter 19 Diversity of encoding: Reward to aversion - p. 237 32. Chapter 20 Dopamine beyond temporal-difference reinforcement learning - p. 251 33. Chapter 21 Habits and dopamine - p. 263 34. Chapter 22 Dopamine for performance evaluation—Insights from songbirds - p. 275 35. Chapter 23 Striking parallels between the dopaminergic systems of flies and mammals - p. 287 36. Chapter 24 Reinforcement learning with dopamine: A convergence of natural and artificial intelligence - p. 305 37. Section 5: Dopamine function in motivated behavior - p. 318 38. Chapter 25 Dopamine and the temporal control of behavior - p. 321 39. Chapter 26 Volition and vigor - p. 329 40. Chapter 27 Why the new definition of “anhedonia” misses the mark on dopamine function: Studies of effort-based aspects of motivation and selection of voluntary physical activity - p. 345 41. Chapter 28 Exploration and behavioral variability - p. 357 42. Chapter 29 Role of dopamine in adaptively tuning motivational bias to the current environment - p. 367 43. Chapter 30 Sex differences in dopamine systems involved in motivation and reward - p. 383 44. Chapter 31 Dopamine and appetite - p. 395 45. Section 6: Dopamine dysregulation: From neurology to psychiatry - p. 405 46. Chapter 32 Neuronal design and determinants of selective neuronal vulnerability of dopaminergic neurons in Parkinson's disease - p. 409 47. Chapter 33 Understanding human dopamine neuron biology in Parkinson's patient cells - p. 429 48. Chapter 34 Dopamine replacement for Parkinson's disease: Clinical approaches and experimental underpinnings - p. 447 49. Chapter 35 Dopamine modulation of synaptic transmission in drug addiction - p. 459 50. Chapter 36 Molecular reprogramming of D1 and D2 dopaminoceptive medium spiny neurons in substance use disorder - p. 471 51. Chapter 37 Human dopamine systems in addiction disorders - p. 483 52. Chapter 38 Apathy and impulsivity in neurological and psychiatric disorders - p. 493 53. Chapter 39 Dopamine dysfunction in psychosis - p. 505 54. Chapter 40 Dopamine systems in impulsive–compulsive behavior - p. 519 55. Index - p. 537
The Handbook of Dopamine captures current understanding of dopamine biology in the brain, including anatomical organization of dopamine neurons, their molecular and genetic diversity, synaptic and circuit connectivity, receptor function and signalling, through to diverse roles in behaviors and finally, dysfunction in disease. This volume compiles a comprehensive set of perspectives from a large number of leading scientists working in dopamine research. The volume describes the current state-of-the-field, summarizing knowledge that has been transformed in the last decade through the advent and application of sophisticated new technologies.
1. The Handbook of Dopamine - p. i 2. Cover image - p. i 3. Title page - p. i 4. Table of Contents - p. i 5. Copyright - p. iv 6. Contributors - p. xi 7. Preface - p. xv 8. A perspective on dopamine - p. xvii 9. Section 1: Molecular neuroanatomy of dopamine neurons: Development, diversity, and connectivity - p. xxxi 10. Chapter 1 The dopamine system from an evolutionary perspective - p. 3 11. Chapter 2 Molecular heterogeneity of midbrain dopamine neurons - p. 13 12. Chapter 3 Building an action circuit with nigrostriatal dopaminergic neurons and striatonigral neurons - p. 25 13. Chapter 4 Anatomy of dopamine neuron projections: Axonal arbors, varicosities, and synapses - p. 37 14. Chapter 5 Dopamine neuron connectomes: Inputs and outputs - p. 49 15. Section 2: Dopamine neuron physiology and dopamine release regulation - p. 62 16. Chapter 6 Electrical patterns of activity in dopamine midbrain neurons in vivo - p. 65 17. Chapter 7 Computational modeling of midbrain dopamine neurons - p. 77 18. Chapter 8 Axonal dopamine release: Molecular mechanisms - p. 93 19. Chapter 9 Somatodendritic dopamine release - p. 101 20. Chapter 10 Axonal regulation of dopamine transmission by striatal neuromodulators - p. 115 21. Chapter 11 Dopamine transporters and the nanoscale organization of the dopamine axon - p. 129 22. Chapter 12 Beyond dopamine: Cotransmission by dopamine neurons - p. 141 23. Section 3: Dopamine signalling: Receptors, postsynaptic integration and plasticity - p. 151 24. Chapter 13 Unveiling activation mechanisms and intrinsic divergence of dopamine receptors based on experimentally determined structures - p. 155 25. Chapter 14 Dopamine receptor drugs and their applications - p. 171 26. Chapter 15 Postsynaptic integration and plasticity in the striatum - p. 187 27. Chapter 16 Dopamine signaling roles in the extrastriatal basal ganglia - p. 201 28. Chapter 17 Postsynaptic integration and plasticity in the prefrontal cortex - p. 213 29. Section 4: Dopamine mechanisms of learning and reinforcement - p. 222 30. Chapter 18 The dopamine reward prediction error signal - p. 223 31. Chapter 19 Diversity of encoding: Reward to aversion - p. 237 32. Chapter 20 Dopamine beyond temporal-difference reinforcement learning - p. 251 33. Chapter 21 Habits and dopamine - p. 263 34. Chapter 22 Dopamine for performance evaluation—Insights from songbirds - p. 275 35. Chapter 23 Striking parallels between the dopaminergic systems of flies and mammals - p. 287 36. Chapter 24 Reinforcement learning with dopamine: A convergence of natural and artificial intelligence - p. 305 37. Section 5: Dopamine function in motivated behavior - p. 318 38. Chapter 25 Dopamine and the temporal control of behavior - p. 321 39. Chapter 26 Volition and vigor - p. 329 40. Chapter 27 Why the new definition of “anhedonia” misses the mark on dopamine function: Studies of effort-based aspects of motivation and selection of voluntary physical activity - p. 345 41. Chapter 28 Exploration and behavioral variability - p. 357 42. Chapter 29 Role of dopamine in adaptively tuning motivational bias to the current environment - p. 367 43. Chapter 30 Sex differences in dopamine systems involved in motivation and reward - p. 383 44. Chapter 31 Dopamine and appetite - p. 395 45. Section 6: Dopamine dysregulation: From neurology to psychiatry - p. 405 46. Chapter 32 Neuronal design and determinants of selective neuronal vulnerability of dopaminergic neurons in Parkinson's disease - p. 409 47. Chapter 33 Understanding human dopamine neuron biology in Parkinson's patient cells - p. 429 48. Chapter 34 Dopamine replacement for Parkinson's disease: Clinical approaches and experimental underpinnings - p. 447 49. Chapter 35 Dopamine modulation of synaptic transmission in drug addiction - p. 459 50. Chapter 36 Molecular reprogramming of D1 and D2 dopaminoceptive medium spiny neurons in substance use disorder - p. 471 51. Chapter 37 Human dopamine systems in addiction disorders - p. 483 52. Chapter 38 Apathy and impulsivity in neurological and psychiatric disorders - p. 493 53. Chapter 39 Dopamine dysfunction in psychosis - p. 505 54. Chapter 40 Dopamine systems in impulsive–compulsive behavior - p. 519 55. Index - p. 537
