The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the middle and posterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson’s, Alzheimer’s and other neurological disorders relate to the hypothalamus.
1. Chapter 1: Introduction: The middle and posterior hypothalamus - p. 1 2. Section 6: Supraoptic and paraventricular nucleus more than a neuroendocrine system - p. 4 3. Chapter 2: Vasopressin and oxytocin beyond the pituitary in the human brain - p. 7 4. Chapter 3: Central and peripheral release of oxytocin: Relevance of neuroendocrine and neurotransmitter actions for physiology and behavior - p. 25 5. Chapter 4: Organization of the neuroendocrine and autonomic hypothalamic paraventricular nucleus - p. 45 6. Chapter 5: Sex differences of oxytocin and vasopressin in social behaviors - p. 68 7. Chapter 6: Oxytocin, eating behavior, and metabolism in humans - p. 89 8. Chapter 7: The supraoptic and paraventricular nuclei in healthy aging and neurodegeneration - p. 105 9. Chapter 8: Perinatal stress and epigenetics - p. 125 10. Chapter 9: The hypothalamus in anxiety disorders - p. 153 11. Chapter 10: Congenital isolated central hypothyroidism: Novel mutations and their functional implications - p. 161 12. Section 7: Zona incerta - p. 169 13. Chapter 11: The zona incerta system: Involvement in attention and movement - p. 173 14. Section 8: Ventromedial nucleus and dorsomedial nucleus - p. 184 15. Chapter 12: The role of the dorsomedial and ventromedial hypothalamus in regulating behaviorally coupled and resting autonomic drive - p. 187 16. Section 9: Circumventricular organs of the hypothalamus - p. 200 17. Chapter 13: The subfornical organ and organum vasculosum of the lamina terminalis: Critical roles in cardiovascular regulation and the control of fluid balance - p. 203 18. Chapter 14: Lamina terminalis fenestration: An important neurosurgical corridor - p. 217 19. Chapter 15: Arcuate nucleus, median eminence, and hypophysial pars tuberalis - p. 227 20. Chapter 16: Tanycytes in the infundibular nucleus and median eminence and their role in the blood–brain barrier - p. 253 21. Chapter 17: The human hypothalamic kisspeptin system: Functional neuroanatomy and clinical perspectives - p. 275 22. Chapter 18: Kisspeptin and neurokinin B expression in the human hypothalamus: Relation to reproduction and gender identity - p. 297 23. Chapter 19: The infundibular peptidergic neurons and glia cells in overeating, obesity, and diabetes - p. 315 24. Chapter 20: Hypothalamus and weight loss in amyotrophic lateral sclerosis - p. 327 25. Introduction: Lateral tuberal nucleus - p. 338 26. Section 11: Lateral hypothalamic area, perifornical area - p. 338 27. Chapter 21: The orexin/hypocretin system in neuropsychiatric disorders: Relation to signs and symptoms - p. 343 28. Chapter 22: Pleasure, addiction, and hypocretin (orexin) - p. 359 29. Section 12: Tuberomamillary complex - p. 374 30. Chapter 23: Histamine receptors, agonists, and antagonists in health and disease - p. 377 31. Chapter 24: The tuberomamillary nucleus in neuropsychiatric disorders - p. 389 32. Section 13: Subthalamic nucleus - p. 399 33. Chapter 25: Imaging of the human subthalamic nucleus - p. 403 34. Chapter 26: Neuropsychiatric effects of subthalamic deep brain stimulation - p. 417 35. Chapter 27: The subthalamic nucleus and the placebo effect in Parkinson's disease - p. 433 36. Section 14: Corpora mamillaria, fornix, and mamillothalamic tract - p. 443 37. Chapter 28: Electrical stimulation of the fornix for the treatment of brain diseases - p. 447 38. Chapter 29: The contribution of mamillary body damage to Wernicke's encephalopathy and Korsakoff's syndrome - p. 455 39. Index - p. 475
The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the middle and posterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson’s, Alzheimer’s and other neurological disorders relate to the hypothalamus.
1. Chapter 1: Introduction: The middle and posterior hypothalamus - p. 1 2. Section 6: Supraoptic and paraventricular nucleus more than a neuroendocrine system - p. 4 3. Chapter 2: Vasopressin and oxytocin beyond the pituitary in the human brain - p. 7 4. Chapter 3: Central and peripheral release of oxytocin: Relevance of neuroendocrine and neurotransmitter actions for physiology and behavior - p. 25 5. Chapter 4: Organization of the neuroendocrine and autonomic hypothalamic paraventricular nucleus - p. 45 6. Chapter 5: Sex differences of oxytocin and vasopressin in social behaviors - p. 68 7. Chapter 6: Oxytocin, eating behavior, and metabolism in humans - p. 89 8. Chapter 7: The supraoptic and paraventricular nuclei in healthy aging and neurodegeneration - p. 105 9. Chapter 8: Perinatal stress and epigenetics - p. 125 10. Chapter 9: The hypothalamus in anxiety disorders - p. 153 11. Chapter 10: Congenital isolated central hypothyroidism: Novel mutations and their functional implications - p. 161 12. Section 7: Zona incerta - p. 169 13. Chapter 11: The zona incerta system: Involvement in attention and movement - p. 173 14. Section 8: Ventromedial nucleus and dorsomedial nucleus - p. 184 15. Chapter 12: The role of the dorsomedial and ventromedial hypothalamus in regulating behaviorally coupled and resting autonomic drive - p. 187 16. Section 9: Circumventricular organs of the hypothalamus - p. 200 17. Chapter 13: The subfornical organ and organum vasculosum of the lamina terminalis: Critical roles in cardiovascular regulation and the control of fluid balance - p. 203 18. Chapter 14: Lamina terminalis fenestration: An important neurosurgical corridor - p. 217 19. Chapter 15: Arcuate nucleus, median eminence, and hypophysial pars tuberalis - p. 227 20. Chapter 16: Tanycytes in the infundibular nucleus and median eminence and their role in the blood–brain barrier - p. 253 21. Chapter 17: The human hypothalamic kisspeptin system: Functional neuroanatomy and clinical perspectives - p. 275 22. Chapter 18: Kisspeptin and neurokinin B expression in the human hypothalamus: Relation to reproduction and gender identity - p. 297 23. Chapter 19: The infundibular peptidergic neurons and glia cells in overeating, obesity, and diabetes - p. 315 24. Chapter 20: Hypothalamus and weight loss in amyotrophic lateral sclerosis - p. 327 25. Introduction: Lateral tuberal nucleus - p. 338 26. Section 11: Lateral hypothalamic area, perifornical area - p. 338 27. Chapter 21: The orexin/hypocretin system in neuropsychiatric disorders: Relation to signs and symptoms - p. 343 28. Chapter 22: Pleasure, addiction, and hypocretin (orexin) - p. 359 29. Section 12: Tuberomamillary complex - p. 374 30. Chapter 23: Histamine receptors, agonists, and antagonists in health and disease - p. 377 31. Chapter 24: The tuberomamillary nucleus in neuropsychiatric disorders - p. 389 32. Section 13: Subthalamic nucleus - p. 399 33. Chapter 25: Imaging of the human subthalamic nucleus - p. 403 34. Chapter 26: Neuropsychiatric effects of subthalamic deep brain stimulation - p. 417 35. Chapter 27: The subthalamic nucleus and the placebo effect in Parkinson's disease - p. 433 36. Section 14: Corpora mamillaria, fornix, and mamillothalamic tract - p. 443 37. Chapter 28: Electrical stimulation of the fornix for the treatment of brain diseases - p. 447 38. Chapter 29: The contribution of mamillary body damage to Wernicke's encephalopathy and Korsakoff's syndrome - p. 455 39. Index - p. 475
