1. Introduction 2. Part I: Background 3. Chapter 1: Origin and Development of the Metabolic Syndrome 4. Chapter 2: Intracellular Signaling Mechanisms Involved in Insulin Action 5. Chapter 3: Cellular Models for the Study of Type 2 Diabetes 6. Chapter 4: Transgenic Animal Models and the Metabolic Syndrome 7. Chapter 5: Aging and the Metabolic Syndrome 8. Chapter 6: Gene/Environment Interaction: Thrifty Genotype Versus Thrifty Phenotype 9. Chapter 7: Epidemiology of the Metabolic Syndrome 10. Part II: Genetics 11. Chapter 8: Genetic Susceptibility to the Metabolic Syndrome 12. Chapter 9: Genomic of Skeletal Muscle and its Implications in the Metabolic Syndrome 13. Chapter 10: The Metabolic Syndrome: Obesity and Diet Modulates the Expression of its Genetic Predisposition 14. Part III: Pathogenesis 15. Chapter 11: Pathophysiology of Insulin Action in Humans 16. Chapter 12: Leptin, Insulin and Blood-Brain Barrier Relations in Obesity 17. Chapter 13: Chronic Inflammatory Hypothesis in the Metabolic Syndrome 18. Chapter 14: Metabolic Syndrome and Adipokines 19. Chapter 15: Role of PPARs in the Pathogenesis of the Metabolic Syndrome 20. Chapter 16: The Lipotoxicity and Glucotoxicity Hypothesis in the Metabolic Syndrome and Type 2 Diabetes 21. Chapter 17: Thermogenesis and the Metabolic Syndrome 22. Chapter 18: Nitric Oxide and Cell Metabolism Dysfunction in the Metabolic Syndrome 23. Part IV: Related Diseases in the Metabolic Syndrome 24. Chapter 19: Endothelial Dysfunction in the Metabolic Syndrome 25. Chapter 20: Hypertension in the Metabolic Syndrome 26. Chapter 21: Dyslipidemia in the Metabolic Syndrome 27. Chapter 22: Alterations in Thrombosis and Fibrinolysis in the Metabolic Syndrome 28. Chapter 23: Insulin Resistance and Coronary Heart Disease 29. Chapter 24: Nonalcoholic Fatty Liver Disease: A new entry in the Metabolic Syndrome? 30. Chapter 25: Hyperinsulinism, Insulin Resistance and Fertility 31. Part V: Prevention and Treatment 32. Chapter 26: Nutritional Treatment in the Metabolic Syndrome 33. Chapter 27: Drug Treatment in the Metabolic Syndrome 34. Chapter 28: The Metabolic Syndrome: Lifestyle, Drugs, or Both? 35. Index
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1. Introduction 2. Part I: Background 3. Chapter 1: Origin and Development of the Metabolic Syndrome 4. Chapter 2: Intracellular Signaling Mechanisms Involved in Insulin Action 5. Chapter 3: Cellular Models for the Study of Type 2 Diabetes 6. Chapter 4: Transgenic Animal Models and the Metabolic Syndrome 7. Chapter 5: Aging and the Metabolic Syndrome 8. Chapter 6: Gene/Environment Interaction: Thrifty Genotype Versus Thrifty Phenotype 9. Chapter 7: Epidemiology of the Metabolic Syndrome 10. Part II: Genetics 11. Chapter 8: Genetic Susceptibility to the Metabolic Syndrome 12. Chapter 9: Genomic of Skeletal Muscle and its Implications in the Metabolic Syndrome 13. Chapter 10: The Metabolic Syndrome: Obesity and Diet Modulates the Expression of its Genetic Predisposition 14. Part III: Pathogenesis 15. Chapter 11: Pathophysiology of Insulin Action in Humans 16. Chapter 12: Leptin, Insulin and Blood-Brain Barrier Relations in Obesity 17. Chapter 13: Chronic Inflammatory Hypothesis in the Metabolic Syndrome 18. Chapter 14: Metabolic Syndrome and Adipokines 19. Chapter 15: Role of PPARs in the Pathogenesis of the Metabolic Syndrome 20. Chapter 16: The Lipotoxicity and Glucotoxicity Hypothesis in the Metabolic Syndrome and Type 2 Diabetes 21. Chapter 17: Thermogenesis and the Metabolic Syndrome 22. Chapter 18: Nitric Oxide and Cell Metabolism Dysfunction in the Metabolic Syndrome 23. Part IV: Related Diseases in the Metabolic Syndrome 24. Chapter 19: Endothelial Dysfunction in the Metabolic Syndrome 25. Chapter 20: Hypertension in the Metabolic Syndrome 26. Chapter 21: Dyslipidemia in the Metabolic Syndrome 27. Chapter 22: Alterations in Thrombosis and Fibrinolysis in the Metabolic Syndrome 28. Chapter 23: Insulin Resistance and Coronary Heart Disease 29. Chapter 24: Nonalcoholic Fatty Liver Disease: A new entry in the Metabolic Syndrome? 30. Chapter 25: Hyperinsulinism, Insulin Resistance and Fertility 31. Part V: Prevention and Treatment 32. Chapter 26: Nutritional Treatment in the Metabolic Syndrome 33. Chapter 27: Drug Treatment in the Metabolic Syndrome 34. Chapter 28: The Metabolic Syndrome: Lifestyle, Drugs, or Both? 35. Index
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