The Microbiome in Prenatal and Neonatal Life clarifies that the microbiome in the maternal fetal unit and immediate changes that occur as new microbes are acquired postnatally play major roles in subsequent health and disease. Rapidly developing technologies for multi-omic analyses and systems biology are shifting paradigms in both scientific knowledge and clinical care with regard to this topic. In essence, we are changing the idea that newborns emerge from sterile environments. As such, in-utero colonization may have impacts on the development of immunity and metabolism that, with epigenetic modifications, will lead to diseases in later life.
In addition, the microbial profile that develops during and after birth depends on mode of delivery, type of feeding (human milk versus formula), and various other environmental factors to which the newborn is exposed.
1. Introduction - p. xi 2. Chapter 1. Evolutionary microbiology - p. 1 3. Chapter 2. The microbiome before birth - p. 9 4. Chapter 3. Mode of delivery effects on the developing microbiome and its consequences - p. 19 5. Chapter 4. The human milk microbiome and associated factors - p. 27 6. Chapter 5. Postnatal colonization of the intestinal tract: Host microbial interactions - p. 37 7. Chapter 6. The lung microbiome - p. 49 8. Chapter 7. Environmental influences - p. 55 9. Chapter 8. The human skin microbiome - p. 67 10. Chapter 9. The brain-gut-microbiota axis - p. 77 11. Chapter 10. The developing microbiome and autoimmunity - p. 89 12. Chapter 11. Necrotizing enterocolitis and the microbiome - p. 99 13. Chapter 12. Microbial therapies in the perinatal and neonatal period - p. 107 14. Chapter 13. The virome - p. 117 15. Chapter 14. Integration with epigenetics - p. 127 16. Chapter 15. The early microbiome and subsequent obesity - p. 137 17. Chapter 16. Epilogue: The future - p. 145 18. Index - p. 147
The Microbiome in Prenatal and Neonatal Life clarifies that the microbiome in the maternal fetal unit and immediate changes that occur as new microbes are acquired postnatally play major roles in subsequent health and disease. Rapidly developing technologies for multi-omic analyses and systems biology are shifting paradigms in both scientific knowledge and clinical care with regard to this topic. In essence, we are changing the idea that newborns emerge from sterile environments. As such, in-utero colonization may have impacts on the development of immunity and metabolism that, with epigenetic modifications, will lead to diseases in later life.
In addition, the microbial profile that develops during and after birth depends on mode of delivery, type of feeding (human milk versus formula), and various other environmental factors to which the newborn is exposed.
1. Introduction - p. xi 2. Chapter 1. Evolutionary microbiology - p. 1 3. Chapter 2. The microbiome before birth - p. 9 4. Chapter 3. Mode of delivery effects on the developing microbiome and its consequences - p. 19 5. Chapter 4. The human milk microbiome and associated factors - p. 27 6. Chapter 5. Postnatal colonization of the intestinal tract: Host microbial interactions - p. 37 7. Chapter 6. The lung microbiome - p. 49 8. Chapter 7. Environmental influences - p. 55 9. Chapter 8. The human skin microbiome - p. 67 10. Chapter 9. The brain-gut-microbiota axis - p. 77 11. Chapter 10. The developing microbiome and autoimmunity - p. 89 12. Chapter 11. Necrotizing enterocolitis and the microbiome - p. 99 13. Chapter 12. Microbial therapies in the perinatal and neonatal period - p. 107 14. Chapter 13. The virome - p. 117 15. Chapter 14. Integration with epigenetics - p. 127 16. Chapter 15. The early microbiome and subsequent obesity - p. 137 17. Chapter 16. Epilogue: The future - p. 145 18. Index - p. 147
