The Molecular Basis of Cancer
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. Contributors - p. vi 7. Preface - p. vi 8. I: Carcinogenesis and Cancer Genetics - p. vi 9. List of Illustrations - p. vi 10. List of Tables - p. vi 11. Chapter 1: Cancer: A Genetic Disorder - p. vi 12. Chapter 2: Oncogenes and Signal Transduction - p. g18 13. Chapter 3: Tumor Suppressor Genes - p. g34 14. Chapter 4: DNA Repair Pathways and Human Cancer - p. g46 15. Chapter 5: Epigenetics and Cancer - p. g66 16. Chapter 6: Infectious Agents and Cancer - p. g78 17. Chapter 7: Environmental Carcinogenesis - p. g102 18. Chapter 8: Animal Models: Flies, Fish, and Yeast - p. g128 19. Chapter 9: Genetic Mouse Models of Cancer - p. g144 20. II: Cancer Biology - p. g153 21. Chapter 10: Cancer Stem Cells and the Microenvironment - p. g153 22. Chapter 11: Regulation of the Cell Cycle - p. g164 23. Chapter 12: Cell Growth - p. g178 24. Chapter 13: The Metabolism of Cell Growth and Proliferation - p. g190 25. Chapter 14: Apoptosis, Necrosis, and Autophagy - p. g206 26. Chapter 15: Cellular Senescence - p. g225 27. Chapter 16: The Role of the Microenvironment in Tumor Initiation, Progression, and Metastasis - p. g237 28. Chapter 17: Tumor Angiogenesis - p. g252 29. Chapter 18: Invasion and Metastasis - p. g267 30. Chapter 19: Inflammation and Cancer - p. g283 31. Chapter 20: Cancer Systems Biology: The Future - p. g293 32. III: Molecular Pathology and Diagnostics - p. g311 33. Chapter 21: Biomarkers for Assessing Risk of Cancer - p. g311 34. Chapter 22: Protein Biomarkers for Detecting Cancer: Molecular Screening - p. g330 35. Chapter 23: The Technology of Analyzing Nucleic Acids in Cancer - p. g346 36. Chapter 24: Understanding and Using Information about Cancer Genomes - p. g356 37. Chapter 25: High-Content Analysis with Cellular and Tissue Systems Biology: A Bridge between Cancer Cell Biology and Tissue-Based Diagnostics - p. g368 38. IV: Molecular Pathogenesis and Therapeutic Targets for Specific Cancers - p. g392 39. Chapter 26: Molecular Genetics of Acute Lymphoblastic Leukemia - p. g392 40. Chapter 27: Molecular Biology of Childhood Neoplasms - p. g405 41. Chapter 28: Biology of Adult Myelocytic Leukemia and Myelodysplasia - p. g418 42. Chapter 29: Lymphoma - p. g431 43. Chapter 30: Multiple Myeloma - p. g453 44. Chapter 31: Molecular Mechanisms of Esophageal Cancer - p. g463 45. Chapter 32: Molecular Basis of Lung Cancer - p. g474 46. Chapter 33: The Molecular Pathogenesis of Head and Neck Cancer - p. g489 47. Chapter 34: Colon and Rectal Cancer - p. g498 48. Chapter 35: Molecular Pathogenesis of Pancreatic Adenocarcinoma - p. g513 49. Chapter 36: The Molecular Biology of Breast Cancer - p. g522 50. Chapter 37: Molecular Pathogenesis of Ovarian Cancer - p. g530 51. Chapter 38: Molecular Basis of Prostate Cancer - p. g546 52. Chapter 39: Molecular Abnormalities in Kidney Cancer - p. g558 53. Chapter 40: The Biology of Primary Brain Tumors - p. g571 54. Chapter 41: Epithelial Skin Cancer - p. g580 55. Chapter 42: Molecular Basis for Treating Cutaneous Melanoma - p. g589 56. Chapter 43: Thyroid Cancer - p. g600 57. Chapter 44: Soft Tissue Sarcomas - p. g607 58. V: Molecular Basis of Cancer Therapy - p. g617 59. Chapter 45: From Bench to Bedside with Targeted Therapies - p. g617 60. Chapter 46: Cancer Therapeutics - p. g634 61. Chapter 47: Natural and Acquired Resistance to Cancer Therapies - p. g648 62. Chapter 48: Phase I Trials Today - p. g659 63. Chapter 49: Pharmacogenomics - p. g673 64. Chapter 50: Monoclonal Antibodies for the Treatment of Cancer - p. g682 65. Chapter 51: Cancer and the Cellular Immune Response - p. g692 66. Chapter 52: Cancer Immunotherapy with Vaccines and Checkpoint Blockade - p. g707 67. Chapter 53: Interferons - p. g734 68. Chapter 54: Gene Therapy and Oncolytic Viruses - p. g752 69. Chapter 55: RNA as a Therapeutic Molecule - p. g765 70. Chapter 56: Heat Shock Protein 90 and the Proteasome: Housekeeping Proteins That Are Also Molecular Targets for Cancer Therapy - p. g778 71. Chapter 57: Hematopoietic Growth Factors and Cytokines - p. g786 72. Chapter 58: Cancer Chemoprevention - p. g807 73. Chapter 59: Molecular Pathology - p. g821 74. Index - p. g834
The Molecular Basis of Cancer
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. Contributors - p. vi 7. Preface - p. vi 8. I: Carcinogenesis and Cancer Genetics - p. vi 9. List of Illustrations - p. vi 10. List of Tables - p. vi 11. Chapter 1: Cancer: A Genetic Disorder - p. vi 12. Chapter 2: Oncogenes and Signal Transduction - p. g18 13. Chapter 3: Tumor Suppressor Genes - p. g34 14. Chapter 4: DNA Repair Pathways and Human Cancer - p. g46 15. Chapter 5: Epigenetics and Cancer - p. g66 16. Chapter 6: Infectious Agents and Cancer - p. g78 17. Chapter 7: Environmental Carcinogenesis - p. g102 18. Chapter 8: Animal Models: Flies, Fish, and Yeast - p. g128 19. Chapter 9: Genetic Mouse Models of Cancer - p. g144 20. II: Cancer Biology - p. g153 21. Chapter 10: Cancer Stem Cells and the Microenvironment - p. g153 22. Chapter 11: Regulation of the Cell Cycle - p. g164 23. Chapter 12: Cell Growth - p. g178 24. Chapter 13: The Metabolism of Cell Growth and Proliferation - p. g190 25. Chapter 14: Apoptosis, Necrosis, and Autophagy - p. g206 26. Chapter 15: Cellular Senescence - p. g225 27. Chapter 16: The Role of the Microenvironment in Tumor Initiation, Progression, and Metastasis - p. g237 28. Chapter 17: Tumor Angiogenesis - p. g252 29. Chapter 18: Invasion and Metastasis - p. g267 30. Chapter 19: Inflammation and Cancer - p. g283 31. Chapter 20: Cancer Systems Biology: The Future - p. g293 32. III: Molecular Pathology and Diagnostics - p. g311 33. Chapter 21: Biomarkers for Assessing Risk of Cancer - p. g311 34. Chapter 22: Protein Biomarkers for Detecting Cancer: Molecular Screening - p. g330 35. Chapter 23: The Technology of Analyzing Nucleic Acids in Cancer - p. g346 36. Chapter 24: Understanding and Using Information about Cancer Genomes - p. g356 37. Chapter 25: High-Content Analysis with Cellular and Tissue Systems Biology: A Bridge between Cancer Cell Biology and Tissue-Based Diagnostics - p. g368 38. IV: Molecular Pathogenesis and Therapeutic Targets for Specific Cancers - p. g392 39. Chapter 26: Molecular Genetics of Acute Lymphoblastic Leukemia - p. g392 40. Chapter 27: Molecular Biology of Childhood Neoplasms - p. g405 41. Chapter 28: Biology of Adult Myelocytic Leukemia and Myelodysplasia - p. g418 42. Chapter 29: Lymphoma - p. g431 43. Chapter 30: Multiple Myeloma - p. g453 44. Chapter 31: Molecular Mechanisms of Esophageal Cancer - p. g463 45. Chapter 32: Molecular Basis of Lung Cancer - p. g474 46. Chapter 33: The Molecular Pathogenesis of Head and Neck Cancer - p. g489 47. Chapter 34: Colon and Rectal Cancer - p. g498 48. Chapter 35: Molecular Pathogenesis of Pancreatic Adenocarcinoma - p. g513 49. Chapter 36: The Molecular Biology of Breast Cancer - p. g522 50. Chapter 37: Molecular Pathogenesis of Ovarian Cancer - p. g530 51. Chapter 38: Molecular Basis of Prostate Cancer - p. g546 52. Chapter 39: Molecular Abnormalities in Kidney Cancer - p. g558 53. Chapter 40: The Biology of Primary Brain Tumors - p. g571 54. Chapter 41: Epithelial Skin Cancer - p. g580 55. Chapter 42: Molecular Basis for Treating Cutaneous Melanoma - p. g589 56. Chapter 43: Thyroid Cancer - p. g600 57. Chapter 44: Soft Tissue Sarcomas - p. g607 58. V: Molecular Basis of Cancer Therapy - p. g617 59. Chapter 45: From Bench to Bedside with Targeted Therapies - p. g617 60. Chapter 46: Cancer Therapeutics - p. g634 61. Chapter 47: Natural and Acquired Resistance to Cancer Therapies - p. g648 62. Chapter 48: Phase I Trials Today - p. g659 63. Chapter 49: Pharmacogenomics - p. g673 64. Chapter 50: Monoclonal Antibodies for the Treatment of Cancer - p. g682 65. Chapter 51: Cancer and the Cellular Immune Response - p. g692 66. Chapter 52: Cancer Immunotherapy with Vaccines and Checkpoint Blockade - p. g707 67. Chapter 53: Interferons - p. g734 68. Chapter 54: Gene Therapy and Oncolytic Viruses - p. g752 69. Chapter 55: RNA as a Therapeutic Molecule - p. g765 70. Chapter 56: Heat Shock Protein 90 and the Proteasome: Housekeeping Proteins That Are Also Molecular Targets for Cancer Therapy - p. g778 71. Chapter 57: Hematopoietic Growth Factors and Cytokines - p. g786 72. Chapter 58: Cancer Chemoprevention - p. g807 73. Chapter 59: Molecular Pathology - p. g821 74. Index - p. g834
