The Natural Anti-Gal Antibody as Foe Turned Friend in Medicine provides a comprehensive review of the natural anti-Gal antibody, which is the most abundant antibody in humans constituting ~1% of immunoglobulins and the carbohydrate antigen it recognizes, the α-gal epitope. It discusses the discovery of this antigen/antibody system, its evolution in mammals, the pathological effects of this antibody, and its possible use in various therapies in humans. Most significantly, the book discusses microbial and regenerative therapies in which an antibody present in all humans may be harnessed as an in vivo pharmaceutical agent that enables a wide variety of therapies.
Some of these therapies are described as experimental studies that are compiled in this book, other already studied therapies in the area of cancer immunotherapy are also included in this book.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. Author Biography - p. xiii 7. Preface - p. xv 8. Acknowledgment - p. xvii 9. Section 1. Background Information on Anti-Gal and the α-Gal Epitope - p. xvii 10. Chapter 1. Anti-Gal in Humans and Its Antigen the α-Gal Epitope - p. 3 11. Chapter 2. Why Do We Produce Anti-Gal: Evolutionary Appearance of Anti-Gal in Old World Primates - p. 23 12. Chapter 3. Anti-Gal Comprises Most of Anti-Blood Group B Antibodies: Landsteiner’s B-Like Enigma - p. 45 13. Chapter 4. Anti-Gal Interaction With Trypanosoma, Leishmania, and Plasmodium Parasites - p. 57 14. Chapter 5. Anti-Gal B Cells Are Tolerized by α-Gal Epitopes in the Absence of T Cell Help - p. 73 15. Section 2. Anti-Gal as Foe - p. 95 16. Chapter 6. Anti-Gal and Other Immune Barriers in Xenotransplantation - p. 99 17. Chapter 7. Anti-Gal IgE Mediates Allergies to Red Meat - p. 117 18. Chapter 8. Anti-Gal and Autoimmunity - p. 129 19. Section 3. Anti-Gal as Friend - p. 145 20. Chapter 9. Anti-Gal-Mediated Amplification of Viral Vaccine Efficacy - p. 149 21. Chapter 10. Cancer Immunotherapy by Anti-Gal-Mediated In Situ Conversion of Tumors Into Autologous Vaccines - p. 171 22. Chapter 11. Anti-Gal as Cancer Cell Destroying Antibody and as Antibiotics Targeted by α-Gal Bifunctional Molecules - p. 199 23. Chapter 12. Acceleration of Wound and Burn Healing by Anti-Gal/α-Gal Nanoparticles Interaction - p. 207 24. Section 4. Future Directions (Hypothetical Therapies Requiring Experimental Validation) - p. 228 25. Chapter 13. Anti-Gal and Anti-non Gal Antibodies in Regeneration of Extracellular Matrix Bio-Implants - p. 231 26. Chapter 14. Post Infarction Regeneration of Ischemic Myocardium by Intramyocardial Injection of α-Gal Nanoparticles - p. 257 27. Chapter 15. Regeneration of Injured Spinal Cord and Peripheral Nerves by α-Gal Nanoparticles - p. 269 28. Chapter 16. Inhalation of α-Gal/Sialic Acid Liposomes for Decreasing Influenza Virus Infection - p. 277 29. Index - p. 287
The Natural Anti-Gal Antibody as Foe Turned Friend in Medicine provides a comprehensive review of the natural anti-Gal antibody, which is the most abundant antibody in humans constituting ~1% of immunoglobulins and the carbohydrate antigen it recognizes, the α-gal epitope. It discusses the discovery of this antigen/antibody system, its evolution in mammals, the pathological effects of this antibody, and its possible use in various therapies in humans. Most significantly, the book discusses microbial and regenerative therapies in which an antibody present in all humans may be harnessed as an in vivo pharmaceutical agent that enables a wide variety of therapies.
Some of these therapies are described as experimental studies that are compiled in this book, other already studied therapies in the area of cancer immunotherapy are also included in this book.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. Author Biography - p. xiii 7. Preface - p. xv 8. Acknowledgment - p. xvii 9. Section 1. Background Information on Anti-Gal and the α-Gal Epitope - p. xvii 10. Chapter 1. Anti-Gal in Humans and Its Antigen the α-Gal Epitope - p. 3 11. Chapter 2. Why Do We Produce Anti-Gal: Evolutionary Appearance of Anti-Gal in Old World Primates - p. 23 12. Chapter 3. Anti-Gal Comprises Most of Anti-Blood Group B Antibodies: Landsteiner’s B-Like Enigma - p. 45 13. Chapter 4. Anti-Gal Interaction With Trypanosoma, Leishmania, and Plasmodium Parasites - p. 57 14. Chapter 5. Anti-Gal B Cells Are Tolerized by α-Gal Epitopes in the Absence of T Cell Help - p. 73 15. Section 2. Anti-Gal as Foe - p. 95 16. Chapter 6. Anti-Gal and Other Immune Barriers in Xenotransplantation - p. 99 17. Chapter 7. Anti-Gal IgE Mediates Allergies to Red Meat - p. 117 18. Chapter 8. Anti-Gal and Autoimmunity - p. 129 19. Section 3. Anti-Gal as Friend - p. 145 20. Chapter 9. Anti-Gal-Mediated Amplification of Viral Vaccine Efficacy - p. 149 21. Chapter 10. Cancer Immunotherapy by Anti-Gal-Mediated In Situ Conversion of Tumors Into Autologous Vaccines - p. 171 22. Chapter 11. Anti-Gal as Cancer Cell Destroying Antibody and as Antibiotics Targeted by α-Gal Bifunctional Molecules - p. 199 23. Chapter 12. Acceleration of Wound and Burn Healing by Anti-Gal/α-Gal Nanoparticles Interaction - p. 207 24. Section 4. Future Directions (Hypothetical Therapies Requiring Experimental Validation) - p. 228 25. Chapter 13. Anti-Gal and Anti-non Gal Antibodies in Regeneration of Extracellular Matrix Bio-Implants - p. 231 26. Chapter 14. Post Infarction Regeneration of Ischemic Myocardium by Intramyocardial Injection of α-Gal Nanoparticles - p. 257 27. Chapter 15. Regeneration of Injured Spinal Cord and Peripheral Nerves by α-Gal Nanoparticles - p. 269 28. Chapter 16. Inhalation of α-Gal/Sialic Acid Liposomes for Decreasing Influenza Virus Infection - p. 277 29. Index - p. 287
