The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_xix 6. Foreword - p. page_xxiii 7. Preface - p. page_xxv 8. Part I: Genetic aspects of depression - p. page_xxv 9. Chapter 1: Epigenetics in depression - p. page_3 10. Chapter 2: Genes, depression, and nuclear DNA - p. page_15 11. Chapter 3: Gene expression in depression: Molecular aspects of postpartum depression - p. page_25 12. Chapter 4: Genetics and epigenetics of the SLC6A4 gene in depression - p. page_37 13. Chapter 5: Molecular basis of tryptophan metabolism disorders associated with depression - p. page_47 14. Chapter 6: Metalloproteinases genes and their relationship with depression - p. page_59 15. Chapter 7: Linking gene regions jointly with environment and depression - p. page_69 16. Part II: Molecular and cellular effects of depression - p. page_76 17. Chapter 8: Linking depression, mRNA translation, and serotonin - p. page_79 18. Chapter 9: Changes in cortical gene expression in major depressive disorders: More evidence implicating inflammatory-related pathways in disease etiology - p. page_89 19. Chapter 10: FKBP5 gene expression as a biomarker for treatment outcome in depression - p. page_101 20. Chapter 11: Neuroimaging a cytokine storm by transducing IL-1α to hippocampal cornu ammonis: COVID-19 SARS-CoV-2 - p. page_107 21. Chapter 12: Linking interleukin-6 and depression - p. page_119 22. Chapter 13: The role of inflammatory signaling in comorbid depression and epilepsy - p. page_127 23. Chapter 14: Brain inflammasomes in depression - p. page_139 24. Chapter 15: Inflammatory factors and depression in substance use disorder - p. page_149 25. Chapter 16: Linking Huntington disease, brain-derived neurotrophic factor, and depressive-like behaviors - p. page_161 26. Chapter 17: Depression and the NMDA receptor/NO/cGMP pathway - p. page_179 27. Chapter 18: Translocator protein (18 kDa TSPO) binding in depression - p. page_189 28. Chapter 19: Axonal transport proteins: What they are and how they relate to depressive behaviors - p. page_197 29. Chapter 20: Molecular features of adenylyl cyclase isoforms and cAMP signaling: A link between adenylyl cyclase 7 and depression - p. page_215 30. Chapter 21: Neurobiology of depression: The role of glycogen synthase kinase 3 - p. page_225 31. Chapter 22: Sortilin/neurotensin receptor-3 and its derived peptides in depression - p. page_235 32. Chapter 23: Implication of Wnt/beta-catenin signaling and its components in depression and neuropsychiatric disorders - p. page_243 33. Chapter 24: The prefrontal cortex in depression: Use of proteomics - p. page_255 34. Part III: Neurological and imaging features - p. page_264 35. Chapter 25: How brain single photon emission computed topography imaging informs the diagnosis and treatment of mood disorders - p. page_267 36. Chapter 26: Resting-state functional magnetic resonance imaging (rsfMRI) in bipolar and unipolar depression - p. page_277 37. Chapter 27: Linking amygdala blood oxygenation-level-dependent (BOLD) activity and frontal EEG in depression - p. page_301 38. Chapter 28: The rostromedial tegmental nucleus: Features and links with alcohol and depression - p. page_311 39. Chapter 29: Human serotonergic neurons, selective serotonin reuptake inhibitor (SSRI) resistance and major depressive disorder - p. page_323 40. Chapter 30: Role of nesfatin-1 in major depression - p. page_331 41. Chapter 31: Impact of NGF signaling on neuroplasticity during depression: Insights in neuroplasticity-dependent therapeutic approaches - p. page_341 42. Chapter 32: Inherited depression and psychological disorders and mental illness by germ cells and their memory - p. page_351 43. Part IV: Behaviour and psychopathological effects - p. page_357 44. Chapter 33: Cognitive function and neurocognitive deficits in depression - p. page_361 45. Chapter 34: Cognitive and interpersonal contributors to relationship distress and depression: A review of the dyadic partner-schema model - p. page_373 46. Chapter 35: Cognitive vulnerability to depression in adolescence - p. page_381 47. Chapter 36: Determining the cognitive performance in the first episode of depression - p. page_389 48. Chapter 37: Body image and depression - p. page_397 49. Chapter 38: Sleep, anxiety, and depression - p. page_405 50. Chapter 39: Depression, anxiety, and quality of life - p. page_415 51. Chapter 40: Reward processing and depression: Current findings and future directions - p. page_425 52. Chapter 41: Sexual functioning in depression - p. page_435 53. Part V: Diet, nutrition and botanicals - p. page_449 54. Chapter 42: Linking dietary glycemic index and depression - p. page_453 55. Chapter 43: Gut microbiota and depression - p. page_463 56. Chapter 44: Linking dietary methyl donors, maternal separation, and depression - p. page_473 57. Chapter 45: Convolvulus pluricaulis usage and depression - p. page_485 58. Chapter 46: Antidepressant activity of Crocus sativus L. and its main constituents: A review - p. page_493 59. Chapter 47: Mechanisms of action of herbal antidepressants - p. page_503 60. Chapter 48: Antidepressant-like effects and mechanisms of the herbal formula Xiaochaihutang in depression - p. page_519 61. Part VI: Resources - p. page_528 62. Chapter 49: Recommended resources on the neuroscience of depression: Genetics, cell biology, neurology, behavior, and diet - p. page_531 63. Index - p. page_539
The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_xix 6. Foreword - p. page_xxiii 7. Preface - p. page_xxv 8. Part I: Genetic aspects of depression - p. page_xxv 9. Chapter 1: Epigenetics in depression - p. page_3 10. Chapter 2: Genes, depression, and nuclear DNA - p. page_15 11. Chapter 3: Gene expression in depression: Molecular aspects of postpartum depression - p. page_25 12. Chapter 4: Genetics and epigenetics of the SLC6A4 gene in depression - p. page_37 13. Chapter 5: Molecular basis of tryptophan metabolism disorders associated with depression - p. page_47 14. Chapter 6: Metalloproteinases genes and their relationship with depression - p. page_59 15. Chapter 7: Linking gene regions jointly with environment and depression - p. page_69 16. Part II: Molecular and cellular effects of depression - p. page_76 17. Chapter 8: Linking depression, mRNA translation, and serotonin - p. page_79 18. Chapter 9: Changes in cortical gene expression in major depressive disorders: More evidence implicating inflammatory-related pathways in disease etiology - p. page_89 19. Chapter 10: FKBP5 gene expression as a biomarker for treatment outcome in depression - p. page_101 20. Chapter 11: Neuroimaging a cytokine storm by transducing IL-1α to hippocampal cornu ammonis: COVID-19 SARS-CoV-2 - p. page_107 21. Chapter 12: Linking interleukin-6 and depression - p. page_119 22. Chapter 13: The role of inflammatory signaling in comorbid depression and epilepsy - p. page_127 23. Chapter 14: Brain inflammasomes in depression - p. page_139 24. Chapter 15: Inflammatory factors and depression in substance use disorder - p. page_149 25. Chapter 16: Linking Huntington disease, brain-derived neurotrophic factor, and depressive-like behaviors - p. page_161 26. Chapter 17: Depression and the NMDA receptor/NO/cGMP pathway - p. page_179 27. Chapter 18: Translocator protein (18 kDa TSPO) binding in depression - p. page_189 28. Chapter 19: Axonal transport proteins: What they are and how they relate to depressive behaviors - p. page_197 29. Chapter 20: Molecular features of adenylyl cyclase isoforms and cAMP signaling: A link between adenylyl cyclase 7 and depression - p. page_215 30. Chapter 21: Neurobiology of depression: The role of glycogen synthase kinase 3 - p. page_225 31. Chapter 22: Sortilin/neurotensin receptor-3 and its derived peptides in depression - p. page_235 32. Chapter 23: Implication of Wnt/beta-catenin signaling and its components in depression and neuropsychiatric disorders - p. page_243 33. Chapter 24: The prefrontal cortex in depression: Use of proteomics - p. page_255 34. Part III: Neurological and imaging features - p. page_264 35. Chapter 25: How brain single photon emission computed topography imaging informs the diagnosis and treatment of mood disorders - p. page_267 36. Chapter 26: Resting-state functional magnetic resonance imaging (rsfMRI) in bipolar and unipolar depression - p. page_277 37. Chapter 27: Linking amygdala blood oxygenation-level-dependent (BOLD) activity and frontal EEG in depression - p. page_301 38. Chapter 28: The rostromedial tegmental nucleus: Features and links with alcohol and depression - p. page_311 39. Chapter 29: Human serotonergic neurons, selective serotonin reuptake inhibitor (SSRI) resistance and major depressive disorder - p. page_323 40. Chapter 30: Role of nesfatin-1 in major depression - p. page_331 41. Chapter 31: Impact of NGF signaling on neuroplasticity during depression: Insights in neuroplasticity-dependent therapeutic approaches - p. page_341 42. Chapter 32: Inherited depression and psychological disorders and mental illness by germ cells and their memory - p. page_351 43. Part IV: Behaviour and psychopathological effects - p. page_357 44. Chapter 33: Cognitive function and neurocognitive deficits in depression - p. page_361 45. Chapter 34: Cognitive and interpersonal contributors to relationship distress and depression: A review of the dyadic partner-schema model - p. page_373 46. Chapter 35: Cognitive vulnerability to depression in adolescence - p. page_381 47. Chapter 36: Determining the cognitive performance in the first episode of depression - p. page_389 48. Chapter 37: Body image and depression - p. page_397 49. Chapter 38: Sleep, anxiety, and depression - p. page_405 50. Chapter 39: Depression, anxiety, and quality of life - p. page_415 51. Chapter 40: Reward processing and depression: Current findings and future directions - p. page_425 52. Chapter 41: Sexual functioning in depression - p. page_435 53. Part V: Diet, nutrition and botanicals - p. page_449 54. Chapter 42: Linking dietary glycemic index and depression - p. page_453 55. Chapter 43: Gut microbiota and depression - p. page_463 56. Chapter 44: Linking dietary methyl donors, maternal separation, and depression - p. page_473 57. Chapter 45: Convolvulus pluricaulis usage and depression - p. page_485 58. Chapter 46: Antidepressant activity of Crocus sativus L. and its main constituents: A review - p. page_493 59. Chapter 47: Mechanisms of action of herbal antidepressants - p. page_503 60. Chapter 48: Antidepressant-like effects and mechanisms of the herbal formula Xiaochaihutang in depression - p. page_519 61. Part VI: Resources - p. page_528 62. Chapter 49: Recommended resources on the neuroscience of depression: Genetics, cell biology, neurology, behavior, and diet - p. page_531 63. Index - p. page_539
